| Full name: death associated protein kinase 3 | Alias Symbol: ZIP|ZIPK | ||
| Type: protein-coding gene | Cytoband: 19p13.3 | ||
| Entrez ID: 1613 | HGNC ID: HGNC:2676 | Ensembl Gene: ENSG00000167657 | OMIM ID: 603289 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
DAPK3 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05200 | Pathways in cancer | |
| hsa05219 | Bladder cancer |
Expression of DAPK3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DAPK3 | 1613 | 228681_x_at | 0.0437 | 0.8534 | |
| GSE26886 | DAPK3 | 1613 | 228681_x_at | 0.3135 | 0.0078 | |
| GSE45670 | DAPK3 | 1613 | 228681_x_at | -0.0575 | 0.5999 | |
| GSE53622 | DAPK3 | 1613 | 3134 | 0.1623 | 0.1017 | |
| GSE53624 | DAPK3 | 1613 | 3134 | 0.7507 | 0.0000 | |
| GSE63941 | DAPK3 | 1613 | 228681_x_at | -0.0247 | 0.8702 | |
| GSE77861 | DAPK3 | 1613 | 228681_x_at | 0.0290 | 0.8059 | |
| GSE97050 | DAPK3 | 1613 | A_33_P3224045 | 0.0231 | 0.9410 | |
| SRP007169 | DAPK3 | 1613 | RNAseq | 0.2968 | 0.6538 | |
| SRP008496 | DAPK3 | 1613 | RNAseq | 0.7832 | 0.0484 | |
| SRP064894 | DAPK3 | 1613 | RNAseq | 0.6456 | 0.0218 | |
| SRP133303 | DAPK3 | 1613 | RNAseq | 0.5945 | 0.0076 | |
| SRP159526 | DAPK3 | 1613 | RNAseq | 0.2504 | 0.3664 | |
| SRP193095 | DAPK3 | 1613 | RNAseq | 0.8277 | 0.0000 | |
| SRP219564 | DAPK3 | 1613 | RNAseq | 0.1864 | 0.7371 | |
| TCGA | DAPK3 | 1613 | RNAseq | 0.0084 | 0.8799 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by DAPK3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DAPK3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DAPK3 | 1613 | 5 | 3 | 22 | |
| GSE20123 | DAPK3 | 1613 | 4 | 2 | 24 | |
| GSE43470 | DAPK3 | 1613 | 1 | 9 | 33 | |
| GSE46452 | DAPK3 | 1613 | 47 | 1 | 11 | |
| GSE47630 | DAPK3 | 1613 | 5 | 7 | 28 | |
| GSE54993 | DAPK3 | 1613 | 16 | 3 | 51 | |
| GSE54994 | DAPK3 | 1613 | 8 | 16 | 29 | |
| GSE60625 | DAPK3 | 1613 | 9 | 0 | 2 | |
| GSE74703 | DAPK3 | 1613 | 1 | 6 | 29 | |
| GSE74704 | DAPK3 | 1613 | 1 | 2 | 17 | |
| TCGA | DAPK3 | 1613 | 11 | 18 | 67 |
Total number of gains: 108; Total number of losses: 67; Total Number of normals: 313.
Somatic mutations of DAPK3:
Generating mutation plots.
Highly correlated genes for DAPK3:
Showing top 20/466 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DAPK3 | CSNK1G2 | 0.796641 | 3 | 0 | 3 |
| DAPK3 | PELP1 | 0.774258 | 3 | 0 | 3 |
| DAPK3 | ZYX | 0.767285 | 3 | 0 | 3 |
| DAPK3 | JMJD4 | 0.761939 | 4 | 0 | 4 |
| DAPK3 | MAST2 | 0.761469 | 4 | 0 | 4 |
| DAPK3 | TP53I11 | 0.756496 | 3 | 0 | 3 |
| DAPK3 | GMEB2 | 0.755019 | 3 | 0 | 3 |
| DAPK3 | PLXNA1 | 0.753315 | 3 | 0 | 3 |
| DAPK3 | NMT1 | 0.74824 | 3 | 0 | 3 |
| DAPK3 | TSEN15 | 0.737165 | 3 | 0 | 3 |
| DAPK3 | NRP2 | 0.734194 | 4 | 0 | 4 |
| DAPK3 | ANO6 | 0.731582 | 3 | 0 | 3 |
| DAPK3 | SRRT | 0.730928 | 3 | 0 | 3 |
| DAPK3 | ZNF579 | 0.729639 | 3 | 0 | 3 |
| DAPK3 | LUC7L | 0.729505 | 3 | 0 | 3 |
| DAPK3 | ABHD16B | 0.726166 | 3 | 0 | 3 |
| DAPK3 | STK17A | 0.725268 | 3 | 0 | 3 |
| DAPK3 | MRPS15 | 0.723377 | 3 | 0 | 3 |
| DAPK3 | ESYT1 | 0.721766 | 3 | 0 | 3 |
| DAPK3 | YWHAG | 0.721591 | 3 | 0 | 3 |
For details and further investigation, click here
