| Full name: exocyst complex component 3 | Alias Symbol: Sec6p | ||
| Type: protein-coding gene | Cytoband: 5p15.33 | ||
| Entrez ID: 11336 | HGNC ID: HGNC:30378 | Ensembl Gene: ENSG00000180104 | OMIM ID: 608186 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of EXOC3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | EXOC3 | 11336 | 212630_at | -0.0374 | 0.9324 | |
| GSE20347 | EXOC3 | 11336 | 212630_at | 0.0148 | 0.9230 | |
| GSE23400 | EXOC3 | 11336 | 212630_at | -0.0389 | 0.6007 | |
| GSE26886 | EXOC3 | 11336 | 212630_at | -0.1684 | 0.4727 | |
| GSE29001 | EXOC3 | 11336 | 212630_at | -0.0468 | 0.9013 | |
| GSE38129 | EXOC3 | 11336 | 212630_at | 0.0532 | 0.6193 | |
| GSE45670 | EXOC3 | 11336 | 212630_at | 0.3761 | 0.0021 | |
| GSE53622 | EXOC3 | 11336 | 3512 | -0.2548 | 0.0013 | |
| GSE53624 | EXOC3 | 11336 | 3512 | -0.2481 | 0.0031 | |
| GSE63941 | EXOC3 | 11336 | 212630_at | 0.5444 | 0.1227 | |
| GSE77861 | EXOC3 | 11336 | 212630_at | 0.2931 | 0.1023 | |
| GSE97050 | EXOC3 | 11336 | A_23_P93046 | 0.0866 | 0.6617 | |
| SRP007169 | EXOC3 | 11336 | RNAseq | 0.6102 | 0.1402 | |
| SRP008496 | EXOC3 | 11336 | RNAseq | -0.5097 | 0.2424 | |
| SRP064894 | EXOC3 | 11336 | RNAseq | -0.2632 | 0.0664 | |
| SRP133303 | EXOC3 | 11336 | RNAseq | -0.1615 | 0.4417 | |
| SRP159526 | EXOC3 | 11336 | RNAseq | -0.0381 | 0.8841 | |
| SRP193095 | EXOC3 | 11336 | RNAseq | 0.0981 | 0.3859 | |
| SRP219564 | EXOC3 | 11336 | RNAseq | -0.0907 | 0.8186 | |
| TCGA | EXOC3 | 11336 | RNAseq | -0.0301 | 0.5546 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by EXOC3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of EXOC3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | EXOC3 | 11336 | 13 | 1 | 16 | |
| GSE20123 | EXOC3 | 11336 | 13 | 1 | 16 | |
| GSE43470 | EXOC3 | 11336 | 16 | 0 | 27 | |
| GSE46452 | EXOC3 | 11336 | 6 | 22 | 31 | |
| GSE47630 | EXOC3 | 11336 | 11 | 9 | 20 | |
| GSE54993 | EXOC3 | 11336 | 5 | 6 | 59 | |
| GSE54994 | EXOC3 | 11336 | 29 | 1 | 23 | |
| GSE60625 | EXOC3 | 11336 | 0 | 0 | 11 | |
| GSE74703 | EXOC3 | 11336 | 13 | 0 | 23 | |
| GSE74704 | EXOC3 | 11336 | 11 | 0 | 9 | |
| TCGA | EXOC3 | 11336 | 60 | 4 | 32 |
Total number of gains: 177; Total number of losses: 44; Total Number of normals: 267.
Somatic mutations of EXOC3:
Generating mutation plots.
Highly correlated genes for EXOC3:
Showing top 20/186 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| EXOC3 | PPP6R2 | 0.794252 | 3 | 0 | 3 |
| EXOC3 | UFM1 | 0.7407 | 3 | 0 | 3 |
| EXOC3 | TRMT112 | 0.724535 | 3 | 0 | 3 |
| EXOC3 | SCAMP3 | 0.721072 | 4 | 0 | 3 |
| EXOC3 | FZD6 | 0.71567 | 3 | 0 | 3 |
| EXOC3 | LTBR | 0.711112 | 3 | 0 | 3 |
| EXOC3 | SLC1A5 | 0.708436 | 3 | 0 | 3 |
| EXOC3 | TNFAIP1 | 0.705005 | 3 | 0 | 3 |
| EXOC3 | FAM89B | 0.701037 | 3 | 0 | 3 |
| EXOC3 | MEGF6 | 0.694154 | 3 | 0 | 3 |
| EXOC3 | U2SURP | 0.690812 | 3 | 0 | 3 |
| EXOC3 | SUMF2 | 0.689351 | 3 | 0 | 3 |
| EXOC3 | MKNK1 | 0.686524 | 4 | 0 | 3 |
| EXOC3 | DTX3 | 0.68651 | 3 | 0 | 3 |
| EXOC3 | ARTN | 0.684269 | 3 | 0 | 3 |
| EXOC3 | TEAD4 | 0.683227 | 3 | 0 | 3 |
| EXOC3 | MAPKAPK2 | 0.679884 | 4 | 0 | 3 |
| EXOC3 | PSMB7 | 0.679612 | 3 | 0 | 3 |
| EXOC3 | C5orf15 | 0.678084 | 3 | 0 | 3 |
| EXOC3 | TPM3 | 0.67004 | 3 | 0 | 3 |
For details and further investigation, click here
