| Full name: lymphotoxin beta receptor | Alias Symbol: TNFCR|TNFR-RP|TNFR2-RP|TNF-R-III|TNFRSF3 | ||
| Type: protein-coding gene | Cytoband: 12p13 | ||
| Entrez ID: 4055 | HGNC ID: HGNC:6718 | Ensembl Gene: | OMIM ID: 600979 |
| Drug and gene relationship at DGIdb | |||
LTBR involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04064 | NF-kappa B signaling pathway | |
| hsa04066 | HIF-1 signaling pathway | |
| hsa05166 | HTLV-I infection |
Expression of LTBR:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LTBR | 4055 | 203005_at | 0.4304 | 0.4767 | |
| GSE20347 | LTBR | 4055 | 203005_at | 0.0722 | 0.6708 | |
| GSE23400 | LTBR | 4055 | 203005_at | 0.2912 | 0.0000 | |
| GSE26886 | LTBR | 4055 | 203005_at | 1.1361 | 0.0000 | |
| GSE29001 | LTBR | 4055 | 203005_at | -0.0194 | 0.9457 | |
| GSE38129 | LTBR | 4055 | 203005_at | 0.1577 | 0.2593 | |
| GSE45670 | LTBR | 4055 | 203005_at | 0.4798 | 0.0129 | |
| GSE63941 | LTBR | 4055 | 203005_at | -0.3778 | 0.4723 | |
| GSE77861 | LTBR | 4055 | 203005_at | 0.5914 | 0.0149 | |
| GSE97050 | LTBR | 4055 | A_23_P53557 | 0.2992 | 0.2434 | |
| SRP007169 | LTBR | 4055 | RNAseq | -0.3649 | 0.3848 | |
| SRP008496 | LTBR | 4055 | RNAseq | -0.2203 | 0.3588 | |
| SRP064894 | LTBR | 4055 | RNAseq | 0.1651 | 0.3990 | |
| SRP133303 | LTBR | 4055 | RNAseq | 0.4299 | 0.0164 | |
| SRP159526 | LTBR | 4055 | RNAseq | -0.0950 | 0.6810 | |
| SRP193095 | LTBR | 4055 | RNAseq | 0.4481 | 0.0001 | |
| SRP219564 | LTBR | 4055 | RNAseq | 0.3244 | 0.1871 | |
| TCGA | LTBR | 4055 | RNAseq | 0.1583 | 0.0031 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by LTBR expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of LTBR:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LTBR | 4055 | 9 | 3 | 18 | |
| GSE20123 | LTBR | 4055 | 9 | 3 | 18 | |
| GSE43470 | LTBR | 4055 | 8 | 3 | 32 | |
| GSE46452 | LTBR | 4055 | 10 | 1 | 48 | |
| GSE47630 | LTBR | 4055 | 12 | 2 | 26 | |
| GSE54993 | LTBR | 4055 | 1 | 10 | 59 | |
| GSE54994 | LTBR | 4055 | 10 | 2 | 41 | |
| GSE60625 | LTBR | 4055 | 0 | 1 | 10 | |
| GSE74703 | LTBR | 4055 | 7 | 2 | 27 | |
| GSE74704 | LTBR | 4055 | 5 | 2 | 13 | |
| TCGA | LTBR | 4055 | 40 | 6 | 50 |
Total number of gains: 111; Total number of losses: 35; Total Number of normals: 342.
Somatic mutations of LTBR:
Generating mutation plots.
Highly correlated genes for LTBR:
Showing top 20/1055 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LTBR | TMEM41A | 0.862357 | 3 | 0 | 3 |
| LTBR | IKBIP | 0.840914 | 3 | 0 | 3 |
| LTBR | CENPV | 0.830932 | 3 | 0 | 3 |
| LTBR | MAN2B1 | 0.81462 | 3 | 0 | 3 |
| LTBR | CPNE2 | 0.812255 | 3 | 0 | 3 |
| LTBR | ACBD6 | 0.810314 | 3 | 0 | 3 |
| LTBR | DRAM1 | 0.794424 | 3 | 0 | 3 |
| LTBR | NGRN | 0.78885 | 3 | 0 | 3 |
| LTBR | CCDC59 | 0.775538 | 3 | 0 | 3 |
| LTBR | NACC1 | 0.774603 | 4 | 0 | 4 |
| LTBR | BRAT1 | 0.773876 | 4 | 0 | 4 |
| LTBR | TP53I13 | 0.77085 | 3 | 0 | 3 |
| LTBR | FBXL19 | 0.770818 | 3 | 0 | 3 |
| LTBR | GNPAT | 0.770755 | 3 | 0 | 3 |
| LTBR | RILPL2 | 0.769584 | 3 | 0 | 3 |
| LTBR | SEL1L3 | 0.769372 | 3 | 0 | 3 |
| LTBR | THEM4 | 0.768683 | 3 | 0 | 3 |
| LTBR | SH2B2 | 0.766161 | 3 | 0 | 3 |
| LTBR | TWSG1 | 0.764943 | 3 | 0 | 3 |
| LTBR | ZSCAN29 | 0.761338 | 3 | 0 | 3 |
For details and further investigation, click here
