| Full name: multiple EGF like domains 6 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 1p36.32 | ||
| Entrez ID: 1953 | HGNC ID: HGNC:3232 | Ensembl Gene: ENSG00000162591 | OMIM ID: 604266 |
| Drug and gene relationship at DGIdb | |||
Expression of MEGF6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MEGF6 | 1953 | 226869_at | 0.1093 | 0.9416 | |
| GSE20347 | MEGF6 | 1953 | 213942_at | 0.0710 | 0.5619 | |
| GSE23400 | MEGF6 | 1953 | 213942_at | -0.0754 | 0.1025 | |
| GSE26886 | MEGF6 | 1953 | 226869_at | 0.6357 | 0.0668 | |
| GSE29001 | MEGF6 | 1953 | 213942_at | -0.2225 | 0.2814 | |
| GSE38129 | MEGF6 | 1953 | 213942_at | 0.0452 | 0.6170 | |
| GSE45670 | MEGF6 | 1953 | 226869_at | 0.2178 | 0.6316 | |
| GSE63941 | MEGF6 | 1953 | 226869_at | -0.9911 | 0.2652 | |
| GSE77861 | MEGF6 | 1953 | 226869_at | 0.1043 | 0.8094 | |
| GSE97050 | MEGF6 | 1953 | A_24_P926960 | -0.0172 | 0.9635 | |
| SRP007169 | MEGF6 | 1953 | RNAseq | 0.0809 | 0.8667 | |
| SRP008496 | MEGF6 | 1953 | RNAseq | 0.8725 | 0.0300 | |
| SRP064894 | MEGF6 | 1953 | RNAseq | -0.1899 | 0.6249 | |
| SRP133303 | MEGF6 | 1953 | RNAseq | -0.2045 | 0.5590 | |
| SRP159526 | MEGF6 | 1953 | RNAseq | -0.1019 | 0.8461 | |
| SRP193095 | MEGF6 | 1953 | RNAseq | 0.1468 | 0.6111 | |
| SRP219564 | MEGF6 | 1953 | RNAseq | -0.3057 | 0.5360 | |
| TCGA | MEGF6 | 1953 | RNAseq | 0.0394 | 0.7126 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by MEGF6 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of MEGF6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MEGF6 | 1953 | 4 | 6 | 20 | |
| GSE20123 | MEGF6 | 1953 | 4 | 5 | 21 | |
| GSE43470 | MEGF6 | 1953 | 3 | 5 | 35 | |
| GSE46452 | MEGF6 | 1953 | 7 | 1 | 51 | |
| GSE47630 | MEGF6 | 1953 | 8 | 4 | 28 | |
| GSE54993 | MEGF6 | 1953 | 3 | 2 | 65 | |
| GSE54994 | MEGF6 | 1953 | 14 | 3 | 36 | |
| GSE60625 | MEGF6 | 1953 | 0 | 0 | 11 | |
| GSE74703 | MEGF6 | 1953 | 3 | 3 | 30 | |
| GSE74704 | MEGF6 | 1953 | 4 | 0 | 16 | |
| TCGA | MEGF6 | 1953 | 14 | 20 | 62 |
Total number of gains: 64; Total number of losses: 49; Total Number of normals: 375.
Somatic mutations of MEGF6:
Generating mutation plots.
Highly correlated genes for MEGF6:
Showing top 20/151 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MEGF6 | CIDEB | 0.794142 | 3 | 0 | 3 |
| MEGF6 | TNPO1 | 0.787318 | 3 | 0 | 3 |
| MEGF6 | NBEAL1 | 0.748626 | 3 | 0 | 3 |
| MEGF6 | INO80D | 0.737033 | 3 | 0 | 3 |
| MEGF6 | CAPN3 | 0.734577 | 3 | 0 | 3 |
| MEGF6 | EEF1D | 0.732744 | 4 | 0 | 4 |
| MEGF6 | LRP4 | 0.714349 | 3 | 0 | 3 |
| MEGF6 | ZNF408 | 0.707361 | 3 | 0 | 3 |
| MEGF6 | RP9 | 0.699884 | 3 | 0 | 3 |
| MEGF6 | LDLRAD3 | 0.696239 | 3 | 0 | 3 |
| MEGF6 | KBTBD2 | 0.695447 | 3 | 0 | 3 |
| MEGF6 | EXOC3 | 0.694154 | 3 | 0 | 3 |
| MEGF6 | HMGN3 | 0.692872 | 4 | 0 | 3 |
| MEGF6 | PPP6R2 | 0.691289 | 4 | 0 | 3 |
| MEGF6 | AP3S1 | 0.684512 | 3 | 0 | 3 |
| MEGF6 | NEK8 | 0.680962 | 4 | 0 | 3 |
| MEGF6 | MAPKAPK2 | 0.680886 | 3 | 0 | 3 |
| MEGF6 | SNX27 | 0.673897 | 3 | 0 | 3 |
| MEGF6 | CYP1A2 | 0.672764 | 4 | 0 | 3 |
| MEGF6 | DECR2 | 0.666484 | 3 | 0 | 3 |
For details and further investigation, click here
