| Full name: TEA domain transcription factor 4 | Alias Symbol: TEF-3|TEFR-1|EFTR-2|RTEF-1 | ||
| Type: protein-coding gene | Cytoband: 12p13.33 | ||
| Entrez ID: 7004 | HGNC ID: HGNC:11717 | Ensembl Gene: ENSG00000197905 | OMIM ID: 601714 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
TEAD4 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04390 | Hippo signaling pathway |
Expression of TEAD4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TEAD4 | 7004 | 204281_at | 0.8578 | 0.0445 | |
| GSE20347 | TEAD4 | 7004 | 204281_at | 0.4823 | 0.0000 | |
| GSE23400 | TEAD4 | 7004 | 204281_at | 0.3188 | 0.0000 | |
| GSE26886 | TEAD4 | 7004 | 204281_at | 1.1087 | 0.0000 | |
| GSE29001 | TEAD4 | 7004 | 204281_at | 0.5133 | 0.0075 | |
| GSE38129 | TEAD4 | 7004 | 204281_at | 0.6118 | 0.0000 | |
| GSE45670 | TEAD4 | 7004 | 204281_at | 0.7031 | 0.0001 | |
| GSE53622 | TEAD4 | 7004 | 6648 | 0.3740 | 0.0000 | |
| GSE53624 | TEAD4 | 7004 | 6648 | 1.0431 | 0.0000 | |
| GSE63941 | TEAD4 | 7004 | 204281_at | 1.1316 | 0.0048 | |
| GSE77861 | TEAD4 | 7004 | 204281_at | 0.4520 | 0.0120 | |
| GSE97050 | TEAD4 | 7004 | A_23_P94795 | -0.1050 | 0.6948 | |
| SRP007169 | TEAD4 | 7004 | RNAseq | 1.8459 | 0.0230 | |
| SRP008496 | TEAD4 | 7004 | RNAseq | 1.9408 | 0.0002 | |
| SRP064894 | TEAD4 | 7004 | RNAseq | 1.5289 | 0.0000 | |
| SRP133303 | TEAD4 | 7004 | RNAseq | 1.5652 | 0.0000 | |
| SRP159526 | TEAD4 | 7004 | RNAseq | 1.2477 | 0.0001 | |
| SRP193095 | TEAD4 | 7004 | RNAseq | 1.6320 | 0.0000 | |
| SRP219564 | TEAD4 | 7004 | RNAseq | 0.9241 | 0.0831 | |
| TCGA | TEAD4 | 7004 | RNAseq | 0.6166 | 0.0000 |
Upregulated datasets: 9; Downregulated datasets: 0.
Survival by TEAD4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TEAD4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TEAD4 | 7004 | 6 | 4 | 20 | |
| GSE20123 | TEAD4 | 7004 | 6 | 4 | 20 | |
| GSE43470 | TEAD4 | 7004 | 11 | 4 | 28 | |
| GSE46452 | TEAD4 | 7004 | 10 | 1 | 48 | |
| GSE47630 | TEAD4 | 7004 | 12 | 2 | 26 | |
| GSE54993 | TEAD4 | 7004 | 1 | 10 | 59 | |
| GSE54994 | TEAD4 | 7004 | 10 | 2 | 41 | |
| GSE60625 | TEAD4 | 7004 | 0 | 1 | 10 | |
| GSE74703 | TEAD4 | 7004 | 11 | 2 | 23 | |
| GSE74704 | TEAD4 | 7004 | 4 | 2 | 14 | |
| TCGA | TEAD4 | 7004 | 40 | 6 | 50 |
Total number of gains: 111; Total number of losses: 38; Total Number of normals: 339.
Somatic mutations of TEAD4:
Generating mutation plots.
Highly correlated genes for TEAD4:
Showing top 20/1922 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TEAD4 | SLC39A3 | 0.784498 | 4 | 0 | 3 |
| TEAD4 | ALKBH6 | 0.781103 | 4 | 0 | 4 |
| TEAD4 | SHANK3 | 0.778056 | 3 | 0 | 3 |
| TEAD4 | SLC46A1 | 0.770232 | 4 | 0 | 4 |
| TEAD4 | TEAD2 | 0.76655 | 6 | 0 | 6 |
| TEAD4 | COMMD2 | 0.762276 | 4 | 0 | 4 |
| TEAD4 | PRELID1 | 0.756895 | 3 | 0 | 3 |
| TEAD4 | TRIB1 | 0.752522 | 3 | 0 | 3 |
| TEAD4 | PDS5B | 0.751303 | 3 | 0 | 3 |
| TEAD4 | EFTUD2 | 0.749608 | 7 | 0 | 7 |
| TEAD4 | CDH3 | 0.742985 | 9 | 0 | 9 |
| TEAD4 | ALG10 | 0.738708 | 4 | 0 | 4 |
| TEAD4 | HAS3 | 0.737573 | 5 | 0 | 5 |
| TEAD4 | YWHAG | 0.73369 | 5 | 0 | 5 |
| TEAD4 | B3GALT6 | 0.73265 | 5 | 0 | 5 |
| TEAD4 | PCED1B | 0.72994 | 3 | 0 | 3 |
| TEAD4 | SH3PXD2B | 0.728757 | 7 | 0 | 7 |
| TEAD4 | ASB2 | 0.727783 | 3 | 0 | 3 |
| TEAD4 | NEK6 | 0.727664 | 5 | 0 | 4 |
| TEAD4 | ZNF414 | 0.727601 | 3 | 0 | 3 |
For details and further investigation, click here
