TPM3

 

Full name: tropomyosin 3 Alias Symbol: TRK
Type: protein-coding gene Cytoband: 1q21.3
Entrez ID: 7170 HGNC ID: HGNC:12012 Ensembl Gene: ENSG00000143549 OMIM ID: 191030
Drug and gene relationship at DGIdb

 

TPM3 involved pathways:

KEGG pathway Description View
hsa04261Adrenergic signaling in cardiomyocytes
hsa05200Pathways in cancer
hsa05216Thyroid cancer

 

Expression of TPM3:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 TPM3 7170 222976_s_at 0.4570 0.1942
GSE20347 TPM3 7170 214365_at 0.0202 0.7866
GSE23400 TPM3 7170 214365_at 0.0185 0.6417
GSE26886 TPM3 7170 222976_s_at -0.3058 0.0558
GSE29001 TPM3 7170 214365_at -0.0689 0.4731
GSE38129 TPM3 7170 214365_at -0.0424 0.4595
GSE45670 TPM3 7170 222976_s_at 0.3453 0.0026
GSE53622 TPM3 7170 105357 0.4987 0.0000
GSE53624 TPM3 7170 105357 0.5855 0.0000
GSE63941 TPM3 7170 222976_s_at 0.3139 0.3742
GSE77861 TPM3 7170 222976_s_at 0.5165 0.0072
GSE97050 TPM3 7170 A_33_P3223980 0.8328 0.1344
SRP007169 TPM3 7170 RNAseq 1.0432 0.0142
SRP008496 TPM3 7170 RNAseq 1.0719 0.0002
SRP064894 TPM3 7170 RNAseq 0.3355 0.0173
SRP133303 TPM3 7170 RNAseq 0.6286 0.0001
SRP159526 TPM3 7170 RNAseq 0.2892 0.1597
SRP193095 TPM3 7170 RNAseq 0.1210 0.2699
SRP219564 TPM3 7170 RNAseq 0.6198 0.1831
TCGA TPM3 7170 RNAseq 0.1326 0.0011

Upregulated datasets: 2; Downregulated datasets: 0.  

 

Survival by TPM3 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of TPM3:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 TPM3 7170 14 0 16
GSE20123 TPM3 7170 14 0 16
GSE43470 TPM3 7170 7 2 34
GSE46452 TPM3 7170 2 1 56
GSE47630 TPM3 7170 14 0 26
GSE54993 TPM3 7170 0 4 66
GSE54994 TPM3 7170 16 0 37
GSE60625 TPM3 7170 0 0 11
GSE74703 TPM3 7170 6 1 29
GSE74704 TPM3 7170 7 0 13
TCGA TPM3 7170 38 2 56

Total number of gains: 118; Total number of losses: 10; Total Number of normals: 360.  

 

Somatic mutations of TPM3:

 

Generating mutation plots.

 

Highly correlated genes for TPM3:

 

Showing top 20/772 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
TPM3PSPC10.792541303
TPM3GTF3C40.754797303
TPM3PHF60.75395303
TPM3FAM89A0.752883303
TPM3RPN10.751942606
TPM3MAP4K40.747174404
TPM3CDH30.742496404
TPM3DERL10.738634404
TPM3EI240.735817303
TPM3SKA10.729912606
TPM3PARVB0.728857303
TPM3XPO60.728735505
TPM3AASDHPPT0.725583303
TPM3ZNF2670.723877303
TPM3CELSR20.723254303
TPM3DCBLD10.720708606
TPM3ELF40.719633605
TPM3LEPROTL10.719362303
TPM3MELK0.715491706
TPM3FAM49B0.712693605

For details and further investigation, click here