| Full name: exocyst complex component 5 | Alias Symbol: SEC10|SEC10P | ||
| Type: protein-coding gene | Cytoband: 14q22.3 | ||
| Entrez ID: 10640 | HGNC ID: HGNC:10696 | Ensembl Gene: ENSG00000070367 | OMIM ID: 604469 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of EXOC5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | EXOC5 | 10640 | 225084_at | 0.2856 | 0.5913 | |
| GSE20347 | EXOC5 | 10640 | 218748_s_at | 0.1926 | 0.4138 | |
| GSE23400 | EXOC5 | 10640 | 218748_s_at | 0.3484 | 0.0000 | |
| GSE26886 | EXOC5 | 10640 | 225084_at | -0.2631 | 0.0301 | |
| GSE29001 | EXOC5 | 10640 | 218748_s_at | -0.1245 | 0.4185 | |
| GSE38129 | EXOC5 | 10640 | 218748_s_at | 0.3107 | 0.1377 | |
| GSE45670 | EXOC5 | 10640 | 225084_at | 0.1392 | 0.2853 | |
| GSE53622 | EXOC5 | 10640 | 21956 | 0.3713 | 0.0000 | |
| GSE53624 | EXOC5 | 10640 | 21956 | 0.4551 | 0.0000 | |
| GSE63941 | EXOC5 | 10640 | 225084_at | -0.2511 | 0.5041 | |
| GSE77861 | EXOC5 | 10640 | 225084_at | 0.4143 | 0.2395 | |
| GSE97050 | EXOC5 | 10640 | A_23_P14464 | 0.3251 | 0.2370 | |
| SRP007169 | EXOC5 | 10640 | RNAseq | 0.4808 | 0.1655 | |
| SRP008496 | EXOC5 | 10640 | RNAseq | 0.6710 | 0.0103 | |
| SRP064894 | EXOC5 | 10640 | RNAseq | 0.1702 | 0.4475 | |
| SRP133303 | EXOC5 | 10640 | RNAseq | 0.3819 | 0.0251 | |
| SRP159526 | EXOC5 | 10640 | RNAseq | -0.3178 | 0.1270 | |
| SRP193095 | EXOC5 | 10640 | RNAseq | -0.0438 | 0.7144 | |
| SRP219564 | EXOC5 | 10640 | RNAseq | 0.0031 | 0.9925 | |
| TCGA | EXOC5 | 10640 | RNAseq | 0.0535 | 0.2695 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by EXOC5 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of EXOC5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | EXOC5 | 10640 | 8 | 3 | 19 | |
| GSE20123 | EXOC5 | 10640 | 8 | 3 | 19 | |
| GSE43470 | EXOC5 | 10640 | 8 | 2 | 33 | |
| GSE46452 | EXOC5 | 10640 | 16 | 3 | 40 | |
| GSE47630 | EXOC5 | 10640 | 11 | 10 | 19 | |
| GSE54993 | EXOC5 | 10640 | 3 | 8 | 59 | |
| GSE54994 | EXOC5 | 10640 | 19 | 4 | 30 | |
| GSE60625 | EXOC5 | 10640 | 0 | 2 | 9 | |
| GSE74703 | EXOC5 | 10640 | 7 | 2 | 27 | |
| GSE74704 | EXOC5 | 10640 | 3 | 2 | 15 | |
| TCGA | EXOC5 | 10640 | 32 | 14 | 50 |
Total number of gains: 115; Total number of losses: 53; Total Number of normals: 320.
Somatic mutations of EXOC5:
Generating mutation plots.
Highly correlated genes for EXOC5:
Showing top 20/446 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| EXOC5 | ZNF544 | 0.755355 | 3 | 0 | 3 |
| EXOC5 | TRNT1 | 0.730252 | 3 | 0 | 3 |
| EXOC5 | TADA1 | 0.725053 | 3 | 0 | 3 |
| EXOC5 | HEATR5A | 0.724669 | 3 | 0 | 3 |
| EXOC5 | PPHLN1 | 0.708579 | 3 | 0 | 3 |
| EXOC5 | RBM26 | 0.700609 | 3 | 0 | 3 |
| EXOC5 | METTL14 | 0.692596 | 3 | 0 | 3 |
| EXOC5 | SMC2 | 0.692097 | 4 | 0 | 4 |
| EXOC5 | TERF1 | 0.688939 | 3 | 0 | 3 |
| EXOC5 | GTF3C4 | 0.688429 | 3 | 0 | 3 |
| EXOC5 | NAA30 | 0.687447 | 7 | 0 | 6 |
| EXOC5 | UBIAD1 | 0.680326 | 3 | 0 | 3 |
| EXOC5 | EFCAB7 | 0.678111 | 3 | 0 | 3 |
| EXOC5 | NMD3 | 0.672832 | 5 | 0 | 5 |
| EXOC5 | POGLUT1 | 0.667539 | 4 | 0 | 3 |
| EXOC5 | ARID2 | 0.667145 | 3 | 0 | 3 |
| EXOC5 | PTS | 0.659927 | 4 | 0 | 4 |
| EXOC5 | SOCS4 | 0.659545 | 7 | 0 | 5 |
| EXOC5 | NR2C2 | 0.659469 | 4 | 0 | 4 |
| EXOC5 | PITRM1 | 0.657088 | 4 | 0 | 3 |
For details and further investigation, click here
