| Full name: suppressor of cytokine signaling 4 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 14q22.3 | ||
| Entrez ID: 122809 | HGNC ID: HGNC:19392 | Ensembl Gene: ENSG00000180008 | OMIM ID: 616337 |
| Drug and gene relationship at DGIdb | |||
SOCS4 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04630 | Jak-STAT signaling pathway | |
| hsa04910 | Insulin signaling pathway | |
| hsa04917 | Prolactin signaling pathway | |
| hsa04930 | Type II diabetes mellitus |
Expression of SOCS4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SOCS4 | 122809 | 226178_at | 0.5627 | 0.1322 | |
| GSE26886 | SOCS4 | 122809 | 226178_at | 0.9230 | 0.0027 | |
| GSE45670 | SOCS4 | 122809 | 226178_at | 0.3444 | 0.0525 | |
| GSE53622 | SOCS4 | 122809 | 84196 | 0.1547 | 0.0794 | |
| GSE53624 | SOCS4 | 122809 | 84196 | 0.4798 | 0.0000 | |
| GSE63941 | SOCS4 | 122809 | 226178_at | -0.3624 | 0.3198 | |
| GSE77861 | SOCS4 | 122809 | 226178_at | 0.8312 | 0.0555 | |
| GSE97050 | SOCS4 | 122809 | A_33_P3349334 | 0.1449 | 0.7673 | |
| SRP007169 | SOCS4 | 122809 | RNAseq | 1.3117 | 0.0123 | |
| SRP008496 | SOCS4 | 122809 | RNAseq | 1.7542 | 0.0000 | |
| SRP064894 | SOCS4 | 122809 | RNAseq | 0.7680 | 0.0009 | |
| SRP133303 | SOCS4 | 122809 | RNAseq | 0.6772 | 0.0002 | |
| SRP159526 | SOCS4 | 122809 | RNAseq | 0.2994 | 0.1674 | |
| SRP193095 | SOCS4 | 122809 | RNAseq | 0.4013 | 0.0018 | |
| SRP219564 | SOCS4 | 122809 | RNAseq | 0.7598 | 0.0725 | |
| TCGA | SOCS4 | 122809 | RNAseq | -0.0604 | 0.2435 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by SOCS4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SOCS4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SOCS4 | 122809 | 8 | 3 | 19 | |
| GSE20123 | SOCS4 | 122809 | 8 | 3 | 19 | |
| GSE43470 | SOCS4 | 122809 | 9 | 1 | 33 | |
| GSE46452 | SOCS4 | 122809 | 16 | 3 | 40 | |
| GSE47630 | SOCS4 | 122809 | 11 | 10 | 19 | |
| GSE54993 | SOCS4 | 122809 | 3 | 8 | 59 | |
| GSE54994 | SOCS4 | 122809 | 19 | 4 | 30 | |
| GSE60625 | SOCS4 | 122809 | 0 | 2 | 9 | |
| GSE74703 | SOCS4 | 122809 | 8 | 1 | 27 | |
| GSE74704 | SOCS4 | 122809 | 3 | 2 | 15 | |
| TCGA | SOCS4 | 122809 | 32 | 14 | 50 |
Total number of gains: 117; Total number of losses: 51; Total Number of normals: 320.
Somatic mutations of SOCS4:
Generating mutation plots.
Highly correlated genes for SOCS4:
Showing top 20/1366 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SOCS4 | SEC16A | 0.780528 | 3 | 0 | 3 |
| SOCS4 | CD3EAP | 0.76828 | 3 | 0 | 3 |
| SOCS4 | TIMM9 | 0.762175 | 8 | 0 | 7 |
| SOCS4 | POLR2K | 0.758772 | 4 | 0 | 4 |
| SOCS4 | RBM17 | 0.75877 | 3 | 0 | 3 |
| SOCS4 | SPTBN1 | 0.744664 | 3 | 0 | 3 |
| SOCS4 | KLHL36 | 0.741845 | 3 | 0 | 3 |
| SOCS4 | NEDD1 | 0.739518 | 6 | 0 | 6 |
| SOCS4 | SLC38A6 | 0.738207 | 6 | 0 | 5 |
| SOCS4 | STK3 | 0.737739 | 5 | 0 | 5 |
| SOCS4 | U2SURP | 0.737394 | 5 | 0 | 5 |
| SOCS4 | CERS2 | 0.731163 | 4 | 0 | 3 |
| SOCS4 | RIMKLB | 0.730967 | 3 | 0 | 3 |
| SOCS4 | PITX2 | 0.730771 | 3 | 0 | 3 |
| SOCS4 | FEZ2 | 0.728508 | 3 | 0 | 3 |
| SOCS4 | G2E3 | 0.728311 | 5 | 0 | 4 |
| SOCS4 | NEIL2 | 0.727948 | 3 | 0 | 3 |
| SOCS4 | GPR107 | 0.726355 | 3 | 0 | 3 |
| SOCS4 | RNMT | 0.725588 | 4 | 0 | 3 |
| SOCS4 | EPPK1 | 0.723404 | 5 | 0 | 4 |
For details and further investigation, click here
