| Full name: structural maintenance of chromosomes 2 | Alias Symbol: hCAP-E|CAP-E | ||
| Type: protein-coding gene | Cytoband: 9q31.1 | ||
| Entrez ID: 10592 | HGNC ID: HGNC:14011 | Ensembl Gene: ENSG00000136824 | OMIM ID: 605576 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of SMC2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SMC2 | 10592 | 204240_s_at | 0.7346 | 0.2453 | |
| GSE20347 | SMC2 | 10592 | 213253_at | 0.4442 | 0.0193 | |
| GSE23400 | SMC2 | 10592 | 204240_s_at | 1.4955 | 0.0000 | |
| GSE26886 | SMC2 | 10592 | 204240_s_at | 0.7088 | 0.0625 | |
| GSE29001 | SMC2 | 10592 | 204240_s_at | 1.2407 | 0.0098 | |
| GSE38129 | SMC2 | 10592 | 213253_at | 0.5565 | 0.0000 | |
| GSE45670 | SMC2 | 10592 | 204240_s_at | 0.8881 | 0.0002 | |
| GSE53622 | SMC2 | 10592 | 15602 | 0.3275 | 0.0001 | |
| GSE53624 | SMC2 | 10592 | 15602 | 0.5554 | 0.0000 | |
| GSE63941 | SMC2 | 10592 | 204240_s_at | 2.0476 | 0.0011 | |
| GSE77861 | SMC2 | 10592 | 204240_s_at | 0.9980 | 0.1312 | |
| GSE97050 | SMC2 | 10592 | A_33_P3378334 | 0.5252 | 0.1932 | |
| SRP007169 | SMC2 | 10592 | RNAseq | 1.6834 | 0.0002 | |
| SRP008496 | SMC2 | 10592 | RNAseq | 1.7344 | 0.0000 | |
| SRP064894 | SMC2 | 10592 | RNAseq | 0.7484 | 0.0104 | |
| SRP133303 | SMC2 | 10592 | RNAseq | 0.7865 | 0.0001 | |
| SRP159526 | SMC2 | 10592 | RNAseq | 0.6148 | 0.0417 | |
| SRP193095 | SMC2 | 10592 | RNAseq | 0.4790 | 0.0001 | |
| SRP219564 | SMC2 | 10592 | RNAseq | 0.4033 | 0.1919 | |
| TCGA | SMC2 | 10592 | RNAseq | 0.3333 | 0.0000 |
Upregulated datasets: 5; Downregulated datasets: 0.
Survival by SMC2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SMC2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SMC2 | 10592 | 4 | 10 | 16 | |
| GSE20123 | SMC2 | 10592 | 5 | 9 | 16 | |
| GSE43470 | SMC2 | 10592 | 7 | 3 | 33 | |
| GSE46452 | SMC2 | 10592 | 6 | 13 | 40 | |
| GSE47630 | SMC2 | 10592 | 1 | 17 | 22 | |
| GSE54993 | SMC2 | 10592 | 3 | 3 | 64 | |
| GSE54994 | SMC2 | 10592 | 9 | 10 | 34 | |
| GSE60625 | SMC2 | 10592 | 0 | 0 | 11 | |
| GSE74703 | SMC2 | 10592 | 6 | 3 | 27 | |
| GSE74704 | SMC2 | 10592 | 2 | 6 | 12 | |
| TCGA | SMC2 | 10592 | 26 | 21 | 49 |
Total number of gains: 69; Total number of losses: 95; Total Number of normals: 324.
Somatic mutations of SMC2:
Generating mutation plots.
Highly correlated genes for SMC2:
Showing top 20/1662 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SMC2 | TAS2R19 | 0.814512 | 3 | 0 | 3 |
| SMC2 | DNAJC9 | 0.794965 | 9 | 0 | 9 |
| SMC2 | ZBTB9 | 0.794372 | 3 | 0 | 3 |
| SMC2 | GPD2 | 0.792477 | 3 | 0 | 3 |
| SMC2 | CDCA2 | 0.784783 | 6 | 0 | 6 |
| SMC2 | RACGAP1 | 0.781755 | 10 | 0 | 10 |
| SMC2 | SNX30 | 0.778495 | 3 | 0 | 3 |
| SMC2 | ZBTB34 | 0.769017 | 3 | 0 | 3 |
| SMC2 | TMTC3 | 0.753987 | 4 | 0 | 3 |
| SMC2 | AEBP2 | 0.751787 | 3 | 0 | 3 |
| SMC2 | SYPL1 | 0.748148 | 3 | 0 | 3 |
| SMC2 | ABCB10 | 0.747708 | 3 | 0 | 3 |
| SMC2 | MRPL38 | 0.746146 | 3 | 0 | 3 |
| SMC2 | RMI1 | 0.742014 | 13 | 0 | 12 |
| SMC2 | NUSAP1 | 0.739115 | 12 | 0 | 12 |
| SMC2 | ORAI1 | 0.739008 | 4 | 0 | 4 |
| SMC2 | CDK1 | 0.738261 | 11 | 0 | 10 |
| SMC2 | SLC30A6 | 0.736391 | 5 | 0 | 4 |
| SMC2 | MRPL42 | 0.735329 | 9 | 0 | 9 |
| SMC2 | ASPM | 0.733994 | 12 | 0 | 11 |
For details and further investigation, click here
