| Full name: mitogen-activated protein kinase kinase kinase 4 | Alias Symbol: MTK1|MAPKKK4|KIAA0213 | ||
| Type: protein-coding gene | Cytoband: 6q26 | ||
| Entrez ID: 4216 | HGNC ID: HGNC:6856 | Ensembl Gene: ENSG00000085511 | OMIM ID: 602425 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
MAP3K4 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04010 | MAPK signaling pathway | |
| hsa04912 | GnRH signaling pathway |
Expression of MAP3K4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MAP3K4 | 4216 | 216199_s_at | -0.0417 | 0.9501 | |
| GSE20347 | MAP3K4 | 4216 | 216199_s_at | -0.3298 | 0.0058 | |
| GSE23400 | MAP3K4 | 4216 | 204089_x_at | -0.2593 | 0.0015 | |
| GSE26886 | MAP3K4 | 4216 | 216199_s_at | -0.0700 | 0.7935 | |
| GSE29001 | MAP3K4 | 4216 | 204089_x_at | -0.4728 | 0.0046 | |
| GSE38129 | MAP3K4 | 4216 | 216199_s_at | -0.1090 | 0.4224 | |
| GSE45670 | MAP3K4 | 4216 | 216199_s_at | -0.1580 | 0.2218 | |
| GSE53622 | MAP3K4 | 4216 | 64014 | -0.3070 | 0.0000 | |
| GSE53624 | MAP3K4 | 4216 | 64014 | -0.3039 | 0.0000 | |
| GSE63941 | MAP3K4 | 4216 | 216199_s_at | -0.6581 | 0.1566 | |
| GSE77861 | MAP3K4 | 4216 | 204089_x_at | -0.0231 | 0.9334 | |
| GSE97050 | MAP3K4 | 4216 | A_33_P3245922 | 0.0456 | 0.9001 | |
| SRP007169 | MAP3K4 | 4216 | RNAseq | -0.5070 | 0.1440 | |
| SRP008496 | MAP3K4 | 4216 | RNAseq | -0.4735 | 0.0349 | |
| SRP064894 | MAP3K4 | 4216 | RNAseq | -0.4823 | 0.0137 | |
| SRP133303 | MAP3K4 | 4216 | RNAseq | 0.0123 | 0.9498 | |
| SRP159526 | MAP3K4 | 4216 | RNAseq | -0.7279 | 0.0000 | |
| SRP193095 | MAP3K4 | 4216 | RNAseq | -0.4022 | 0.0134 | |
| SRP219564 | MAP3K4 | 4216 | RNAseq | -0.1831 | 0.7133 | |
| TCGA | MAP3K4 | 4216 | RNAseq | 0.1013 | 0.0599 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by MAP3K4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MAP3K4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MAP3K4 | 4216 | 1 | 5 | 24 | |
| GSE20123 | MAP3K4 | 4216 | 1 | 4 | 25 | |
| GSE43470 | MAP3K4 | 4216 | 3 | 0 | 40 | |
| GSE46452 | MAP3K4 | 4216 | 3 | 10 | 46 | |
| GSE47630 | MAP3K4 | 4216 | 9 | 4 | 27 | |
| GSE54993 | MAP3K4 | 4216 | 4 | 4 | 62 | |
| GSE54994 | MAP3K4 | 4216 | 8 | 9 | 36 | |
| GSE60625 | MAP3K4 | 4216 | 0 | 1 | 10 | |
| GSE74703 | MAP3K4 | 4216 | 3 | 0 | 33 | |
| GSE74704 | MAP3K4 | 4216 | 0 | 2 | 18 | |
| TCGA | MAP3K4 | 4216 | 13 | 22 | 61 |
Total number of gains: 45; Total number of losses: 61; Total Number of normals: 382.
Somatic mutations of MAP3K4:
Generating mutation plots.
Highly correlated genes for MAP3K4:
Showing top 20/86 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MAP3K4 | TRIM41 | 0.726085 | 3 | 0 | 3 |
| MAP3K4 | EXOSC1 | 0.718633 | 3 | 0 | 3 |
| MAP3K4 | ATAD2B | 0.699892 | 3 | 0 | 3 |
| MAP3K4 | FTCD | 0.69161 | 3 | 0 | 3 |
| MAP3K4 | ZNF182 | 0.658106 | 3 | 0 | 3 |
| MAP3K4 | KRT77 | 0.643304 | 4 | 0 | 3 |
| MAP3K4 | ATP6AP2 | 0.642552 | 4 | 0 | 4 |
| MAP3K4 | CLECL1 | 0.642426 | 3 | 0 | 3 |
| MAP3K4 | MFSD2B | 0.642118 | 3 | 0 | 3 |
| MAP3K4 | SHROOM4 | 0.622251 | 4 | 0 | 3 |
| MAP3K4 | ZNF524 | 0.615384 | 4 | 0 | 3 |
| MAP3K4 | TMEM37 | 0.612574 | 3 | 0 | 3 |
| MAP3K4 | POR | 0.611388 | 4 | 0 | 3 |
| MAP3K4 | BRD1 | 0.603801 | 3 | 0 | 3 |
| MAP3K4 | PDZRN3 | 0.600683 | 4 | 0 | 3 |
| MAP3K4 | ARFGEF1 | 0.595775 | 5 | 0 | 3 |
| MAP3K4 | RANBP2 | 0.593333 | 4 | 0 | 3 |
| MAP3K4 | AZU1 | 0.588884 | 4 | 0 | 3 |
| MAP3K4 | NT5C2 | 0.588333 | 6 | 0 | 6 |
| MAP3K4 | CCDC130 | 0.580688 | 4 | 0 | 3 |
For details and further investigation, click here
