| Full name: exostosin like glycosyltransferase 2 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 1p21.2 | ||
| Entrez ID: 2135 | HGNC ID: HGNC:3516 | Ensembl Gene: ENSG00000162694 | OMIM ID: 602411 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of EXTL2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | EXTL2 | 2135 | 209537_at | 0.3523 | 0.7378 | |
| GSE20347 | EXTL2 | 2135 | 209537_at | 0.7943 | 0.0016 | |
| GSE23400 | EXTL2 | 2135 | 209537_at | 0.4153 | 0.0000 | |
| GSE26886 | EXTL2 | 2135 | 209537_at | 1.2100 | 0.0001 | |
| GSE29001 | EXTL2 | 2135 | 209537_at | 0.7393 | 0.0014 | |
| GSE38129 | EXTL2 | 2135 | 209537_at | 0.4976 | 0.0635 | |
| GSE45670 | EXTL2 | 2135 | 209537_at | -0.2499 | 0.3884 | |
| GSE53622 | EXTL2 | 2135 | 77046 | 0.8756 | 0.0000 | |
| GSE53624 | EXTL2 | 2135 | 77046 | 1.0924 | 0.0000 | |
| GSE63941 | EXTL2 | 2135 | 209537_at | -1.4874 | 0.0058 | |
| GSE77861 | EXTL2 | 2135 | 209537_at | 0.2074 | 0.5893 | |
| GSE97050 | EXTL2 | 2135 | A_23_P118 | 0.0643 | 0.8481 | |
| SRP007169 | EXTL2 | 2135 | RNAseq | 1.8247 | 0.0001 | |
| SRP008496 | EXTL2 | 2135 | RNAseq | 2.1624 | 0.0000 | |
| SRP064894 | EXTL2 | 2135 | RNAseq | 0.8601 | 0.0001 | |
| SRP133303 | EXTL2 | 2135 | RNAseq | 0.6476 | 0.0006 | |
| SRP159526 | EXTL2 | 2135 | RNAseq | 0.7132 | 0.1346 | |
| SRP193095 | EXTL2 | 2135 | RNAseq | 0.8023 | 0.0001 | |
| SRP219564 | EXTL2 | 2135 | RNAseq | -0.1229 | 0.8658 | |
| TCGA | EXTL2 | 2135 | RNAseq | -0.0436 | 0.6279 |
Upregulated datasets: 4; Downregulated datasets: 1.
Survival by EXTL2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of EXTL2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | EXTL2 | 2135 | 0 | 10 | 20 | |
| GSE20123 | EXTL2 | 2135 | 0 | 10 | 20 | |
| GSE43470 | EXTL2 | 2135 | 2 | 6 | 35 | |
| GSE46452 | EXTL2 | 2135 | 1 | 1 | 57 | |
| GSE47630 | EXTL2 | 2135 | 9 | 5 | 26 | |
| GSE54993 | EXTL2 | 2135 | 0 | 1 | 69 | |
| GSE54994 | EXTL2 | 2135 | 6 | 3 | 44 | |
| GSE60625 | EXTL2 | 2135 | 0 | 0 | 11 | |
| GSE74703 | EXTL2 | 2135 | 1 | 5 | 30 | |
| GSE74704 | EXTL2 | 2135 | 0 | 6 | 14 | |
| TCGA | EXTL2 | 2135 | 8 | 25 | 63 |
Total number of gains: 27; Total number of losses: 72; Total Number of normals: 389.
Somatic mutations of EXTL2:
Generating mutation plots.
Highly correlated genes for EXTL2:
Showing top 20/1220 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| EXTL2 | TNFRSF19 | 0.782293 | 3 | 0 | 3 |
| EXTL2 | RAB34 | 0.767342 | 3 | 0 | 3 |
| EXTL2 | CEP170 | 0.730511 | 3 | 0 | 3 |
| EXTL2 | CPSF3 | 0.724106 | 3 | 0 | 3 |
| EXTL2 | RIOK1 | 0.719402 | 3 | 0 | 3 |
| EXTL2 | MMD | 0.706204 | 12 | 0 | 11 |
| EXTL2 | NF1 | 0.704325 | 3 | 0 | 3 |
| EXTL2 | CHST15 | 0.703595 | 11 | 0 | 11 |
| EXTL2 | SLC39A10 | 0.700738 | 7 | 0 | 7 |
| EXTL2 | C1orf216 | 0.692155 | 11 | 0 | 10 |
| EXTL2 | BPGM | 0.691822 | 4 | 0 | 4 |
| EXTL2 | LAMC1 | 0.691274 | 13 | 0 | 12 |
| EXTL2 | PIAS4 | 0.686275 | 3 | 0 | 3 |
| EXTL2 | COL4A2 | 0.685162 | 12 | 0 | 11 |
| EXTL2 | KCTD7 | 0.681894 | 3 | 0 | 3 |
| EXTL2 | ICAM5 | 0.680155 | 4 | 0 | 3 |
| EXTL2 | DZIP1 | 0.680081 | 10 | 0 | 10 |
| EXTL2 | WDR54 | 0.67718 | 5 | 0 | 5 |
| EXTL2 | SPIRE1 | 0.676395 | 4 | 0 | 3 |
| EXTL2 | C11orf96 | 0.676037 | 4 | 0 | 4 |
For details and further investigation, click here
