MMD

 

Full name: monocyte to macrophage differentiation associated Alias Symbol: MMA|PAQR11
Type: protein-coding gene Cytoband: 17q22
Entrez ID: 23531 HGNC ID: HGNC:7153 Ensembl Gene: ENSG00000108960 OMIM ID: 604467
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of MMD:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 MMD 23531 203414_at 0.6628 0.4586
GSE20347 MMD 23531 203414_at 1.6608 0.0000
GSE23400 MMD 23531 203414_at 1.1724 0.0000
GSE26886 MMD 23531 203414_at 2.1108 0.0000
GSE29001 MMD 23531 203414_at 1.6847 0.0000
GSE38129 MMD 23531 203414_at 1.2517 0.0001
GSE45670 MMD 23531 203414_at 0.2212 0.5833
GSE53622 MMD 23531 78653 1.2420 0.0000
GSE53624 MMD 23531 78653 1.5609 0.0000
GSE63941 MMD 23531 203414_at -3.4041 0.0001
GSE77861 MMD 23531 203414_at 1.5953 0.0005
GSE97050 MMD 23531 A_23_P164047 0.3788 0.2579
SRP007169 MMD 23531 RNAseq 3.0086 0.0000
SRP008496 MMD 23531 RNAseq 2.6925 0.0000
SRP064894 MMD 23531 RNAseq 1.5748 0.0000
SRP133303 MMD 23531 RNAseq 2.1091 0.0000
SRP159526 MMD 23531 RNAseq 1.3308 0.0000
SRP193095 MMD 23531 RNAseq 1.6955 0.0000
SRP219564 MMD 23531 RNAseq 0.5779 0.4269
TCGA MMD 23531 RNAseq 0.4389 0.0000

Upregulated datasets: 14; Downregulated datasets: 1.  

 

Survival by MMD expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of MMD:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 MMD 23531 4 1 25
GSE20123 MMD 23531 4 1 25
GSE43470 MMD 23531 2 1 40
GSE46452 MMD 23531 32 0 27
GSE47630 MMD 23531 7 1 32
GSE54993 MMD 23531 2 4 64
GSE54994 MMD 23531 9 5 39
GSE60625 MMD 23531 4 0 7
GSE74703 MMD 23531 2 1 33
GSE74704 MMD 23531 3 1 16
TCGA MMD 23531 27 7 62

Total number of gains: 96; Total number of losses: 22; Total Number of normals: 370.  

 

Somatic mutations of MMD:

 

Generating mutation plots.

 

Highly correlated genes for MMD:

 

Showing top 20/1671 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
MMDCHN10.81216513013
MMDVCAN0.81182313013
MMDFADS10.809429303
MMDCALU0.79502712012
MMDPXDN0.78074313012
MMDSLC39A140.78063312012
MMDCDH110.78014213013
MMDFSTL10.77635413013
MMDTMEM2630.775123707
MMDFCGR3A0.771835303
MMDFNDC10.769159808
MMDRAB340.768512404
MMDLGALS10.76611313013
MMDSPARC0.76561213013
MMDCOL6A30.7655113013
MMDTNFAIP60.76530113013
MMDCHST150.76349212011
MMDCOL12A10.762094908
MMDCOL4A20.76010813011
MMDFKBP70.757379707

For details and further investigation, click here