| Full name: cleavage and polyadenylation specific factor 3 | Alias Symbol: CPSF-73|CPSF73|YSH1 | ||
| Type: protein-coding gene | Cytoband: 2p25.1 | ||
| Entrez ID: 51692 | HGNC ID: HGNC:2326 | Ensembl Gene: ENSG00000119203 | OMIM ID: 606029 |
| Drug and gene relationship at DGIdb | |||
Expression of CPSF3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CPSF3 | 51692 | 225082_at | 0.5438 | 0.2618 | |
| GSE26886 | CPSF3 | 51692 | 225082_at | 0.8669 | 0.0000 | |
| GSE45670 | CPSF3 | 51692 | 225082_at | 0.5532 | 0.0002 | |
| GSE53622 | CPSF3 | 51692 | 106911 | 0.5747 | 0.0000 | |
| GSE53624 | CPSF3 | 51692 | 106911 | 0.5694 | 0.0000 | |
| GSE63941 | CPSF3 | 51692 | 225082_at | 0.3248 | 0.2994 | |
| GSE77861 | CPSF3 | 51692 | 225082_at | 0.5680 | 0.0301 | |
| GSE97050 | CPSF3 | 51692 | A_23_P28688 | 0.5365 | 0.1296 | |
| SRP007169 | CPSF3 | 51692 | RNAseq | 0.8877 | 0.0198 | |
| SRP008496 | CPSF3 | 51692 | RNAseq | 0.8219 | 0.0008 | |
| SRP064894 | CPSF3 | 51692 | RNAseq | 0.6407 | 0.0000 | |
| SRP133303 | CPSF3 | 51692 | RNAseq | 0.6971 | 0.0000 | |
| SRP159526 | CPSF3 | 51692 | RNAseq | 0.6500 | 0.0138 | |
| SRP193095 | CPSF3 | 51692 | RNAseq | 0.3658 | 0.0036 | |
| SRP219564 | CPSF3 | 51692 | RNAseq | 0.2451 | 0.4287 | |
| TCGA | CPSF3 | 51692 | RNAseq | 0.3031 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by CPSF3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CPSF3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CPSF3 | 51692 | 11 | 2 | 17 | |
| GSE20123 | CPSF3 | 51692 | 11 | 2 | 17 | |
| GSE43470 | CPSF3 | 51692 | 2 | 1 | 40 | |
| GSE46452 | CPSF3 | 51692 | 3 | 4 | 52 | |
| GSE47630 | CPSF3 | 51692 | 7 | 0 | 33 | |
| GSE54993 | CPSF3 | 51692 | 0 | 7 | 63 | |
| GSE54994 | CPSF3 | 51692 | 11 | 1 | 41 | |
| GSE60625 | CPSF3 | 51692 | 0 | 3 | 8 | |
| GSE74703 | CPSF3 | 51692 | 2 | 0 | 34 | |
| GSE74704 | CPSF3 | 51692 | 9 | 1 | 10 | |
| TCGA | CPSF3 | 51692 | 34 | 5 | 57 |
Total number of gains: 90; Total number of losses: 26; Total Number of normals: 372.
Somatic mutations of CPSF3:
Generating mutation plots.
Highly correlated genes for CPSF3:
Showing top 20/1776 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CPSF3 | CD44 | 0.824387 | 3 | 0 | 3 |
| CPSF3 | PDPR | 0.808672 | 4 | 0 | 4 |
| CPSF3 | GSR | 0.805448 | 4 | 0 | 4 |
| CPSF3 | C19orf54 | 0.803073 | 3 | 0 | 3 |
| CPSF3 | UBR1 | 0.790307 | 3 | 0 | 3 |
| CPSF3 | A4GALT | 0.787709 | 3 | 0 | 3 |
| CPSF3 | TRAF7 | 0.786919 | 5 | 0 | 5 |
| CPSF3 | CCT6A | 0.783463 | 5 | 0 | 5 |
| CPSF3 | SLC6A6 | 0.773148 | 3 | 0 | 3 |
| CPSF3 | BIRC6 | 0.765131 | 4 | 0 | 4 |
| CPSF3 | ANKRD11 | 0.764134 | 3 | 0 | 3 |
| CPSF3 | TPMT | 0.762002 | 3 | 0 | 3 |
| CPSF3 | TMED8 | 0.761963 | 3 | 0 | 3 |
| CPSF3 | ITGB8 | 0.760942 | 4 | 0 | 4 |
| CPSF3 | TMEM223 | 0.759776 | 5 | 0 | 5 |
| CPSF3 | WIPF2 | 0.757426 | 3 | 0 | 3 |
| CPSF3 | SLC4A1AP | 0.755267 | 8 | 0 | 8 |
| CPSF3 | ROMO1 | 0.750258 | 3 | 0 | 3 |
| CPSF3 | CAD | 0.748471 | 8 | 0 | 8 |
| CPSF3 | MEF2A | 0.745955 | 5 | 0 | 5 |
For details and further investigation, click here
