| Full name: coagulation factor VIII | Alias Symbol: FVIII|DXS1253E|HEMA | ||
| Type: protein-coding gene | Cytoband: Xq28 | ||
| Entrez ID: 2157 | HGNC ID: HGNC:3546 | Ensembl Gene: ENSG00000185010 | OMIM ID: 300841 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
F8 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04610 | Complement and coagulation cascades |
Expression of F8:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | F8 | 2157 | 205756_s_at | -0.7022 | 0.3393 | |
| GSE20347 | F8 | 2157 | 205756_s_at | 0.3220 | 0.2972 | |
| GSE23400 | F8 | 2157 | 205756_s_at | -0.0686 | 0.2869 | |
| GSE26886 | F8 | 2157 | 205756_s_at | 0.8122 | 0.0226 | |
| GSE29001 | F8 | 2157 | 205756_s_at | 0.1000 | 0.7871 | |
| GSE38129 | F8 | 2157 | 205756_s_at | -0.0882 | 0.8209 | |
| GSE45670 | F8 | 2157 | 205756_s_at | -0.6104 | 0.0452 | |
| GSE53622 | F8 | 2157 | 32547 | -0.2119 | 0.0743 | |
| GSE53624 | F8 | 2157 | 32547 | 0.0138 | 0.9281 | |
| GSE63941 | F8 | 2157 | 205756_s_at | -0.9223 | 0.2653 | |
| GSE77861 | F8 | 2157 | 205756_s_at | 0.1376 | 0.7303 | |
| GSE97050 | F8 | 2157 | A_24_P314451 | -0.2890 | 0.3207 | |
| SRP007169 | F8 | 2157 | RNAseq | -0.3815 | 0.5670 | |
| SRP008496 | F8 | 2157 | RNAseq | 0.9552 | 0.0620 | |
| SRP064894 | F8 | 2157 | RNAseq | 0.5084 | 0.0267 | |
| SRP133303 | F8 | 2157 | RNAseq | -0.0134 | 0.9660 | |
| SRP159526 | F8 | 2157 | RNAseq | 0.2485 | 0.4571 | |
| SRP193095 | F8 | 2157 | RNAseq | 0.3659 | 0.0515 | |
| SRP219564 | F8 | 2157 | RNAseq | -0.0166 | 0.9798 | |
| TCGA | F8 | 2157 | RNAseq | -0.4237 | 0.0002 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by F8 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of F8:
No record found for this gene.
Somatic mutations of F8:
Generating mutation plots.
Highly correlated genes for F8:
Showing top 20/961 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| F8 | MSI2 | 0.784266 | 3 | 0 | 3 |
| F8 | MYEF2 | 0.768383 | 3 | 0 | 3 |
| F8 | RNF214 | 0.754177 | 3 | 0 | 3 |
| F8 | LONRF2 | 0.75367 | 3 | 0 | 3 |
| F8 | WNT6 | 0.743307 | 3 | 0 | 3 |
| F8 | IQUB | 0.741746 | 3 | 0 | 3 |
| F8 | RHOJ | 0.734256 | 4 | 0 | 4 |
| F8 | ARRDC4 | 0.720583 | 3 | 0 | 3 |
| F8 | DOCK11 | 0.718181 | 3 | 0 | 3 |
| F8 | ADH5 | 0.713649 | 3 | 0 | 3 |
| F8 | POLR2I | 0.713233 | 3 | 0 | 3 |
| F8 | TNFSF12 | 0.708361 | 3 | 0 | 3 |
| F8 | ZNF251 | 0.704981 | 3 | 0 | 3 |
| F8 | ZNF25 | 0.70331 | 6 | 0 | 6 |
| F8 | EBF3 | 0.703111 | 4 | 0 | 3 |
| F8 | EMILIN2 | 0.702199 | 3 | 0 | 3 |
| F8 | EID1 | 0.699078 | 8 | 0 | 7 |
| F8 | CD99L2 | 0.697575 | 5 | 0 | 4 |
| F8 | CCDC149 | 0.694995 | 3 | 0 | 3 |
| F8 | RFX5 | 0.690197 | 3 | 0 | 3 |
For details and further investigation, click here
