WNT6

 

Full name: Wnt family member 6 Alias Symbol: 
Type: protein-coding gene Cytoband: 2q35
Entrez ID: 7475 HGNC ID: HGNC:12785 Ensembl Gene: ENSG00000115596 OMIM ID: 604663
Screen Evidence:

 

WNT6 involved pathways:

KEGG pathway Description View
hsa04150mTOR signaling pathway
hsa04310Wnt signaling pathway
hsa04390Hippo signaling pathway
hsa04550Signaling pathways regulating pluripotency of stem cells
hsa04916Melanogenesis
hsa05166HTLV-I infection
hsa05200Pathways in cancer
hsa05205Proteoglycans in cancer
hsa05217Basal cell carcinoma

 

Expression of WNT6:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 WNT6 7475 71933_at -0.1592 0.5682
GSE20347 WNT6 7475 71933_at -0.0187 0.9156
GSE23400 WNT6 7475 71933_at -0.1177 0.0327
GSE26886 WNT6 7475 71933_at 0.0788 0.4271
GSE29001 WNT6 7475 71933_at -0.0682 0.7329
GSE38129 WNT6 7475 71933_at -0.2107 0.0796
GSE45670 WNT6 7475 71933_at 0.0239 0.8300
GSE53622 WNT6 7475 29884 0.3395 0.0742
GSE53624 WNT6 7475 29884 0.0428 0.8049
GSE63941 WNT6 7475 71933_at -0.3728 0.0455
GSE77861 WNT6 7475 71933_at -0.1693 0.2249
GSE97050 WNT6 7475 A_23_P119916 -0.1126 0.6396
SRP133303 WNT6 7475 RNAseq -0.2085 0.3743
SRP219564 WNT6 7475 RNAseq -0.7104 0.1169
TCGA WNT6 7475 RNAseq -0.0791 0.8310

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by WNT6 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of WNT6:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 WNT6 7475 1 14 15
GSE20123 WNT6 7475 1 13 16
GSE43470 WNT6 7475 1 7 35
GSE46452 WNT6 7475 0 5 54
GSE47630 WNT6 7475 4 5 31
GSE54993 WNT6 7475 1 2 67
GSE54994 WNT6 7475 7 10 36
GSE60625 WNT6 7475 0 3 8
GSE74703 WNT6 7475 1 5 30
GSE74704 WNT6 7475 1 7 12
TCGA WNT6 7475 11 27 58

Total number of gains: 28; Total number of losses: 98; Total Number of normals: 362.  

 

Somatic mutations of WNT6:

 

Generating mutation plots.

 

Highly correlated genes for WNT6:

 

Showing top 20/559 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
WNT6DOK60.754978303
WNT6CYP4V20.74817303
WNT6MUC5AC0.746581303
WNT6F80.743307303
WNT6ZNF5780.731297303
WNT6RAPGEF20.726988303
WNT6LUZP40.720451606
WNT6HOTTIP0.716032303
WNT6AKAP140.712651303
WNT6PHYHIPL0.709975303
WNT6KRT710.707039303
WNT6KCNJ100.704057303
WNT6DNAJB40.703566303
WNT6CDK150.697139404
WNT6ZNF5830.692777303
WNT6LRRK20.687936303
WNT6ITGA10.680002303
WNT6SLC25A350.677783303
WNT6DLC10.676266303
WNT6CLDN20.676151303

For details and further investigation, click here