| Full name: SPC24 component of NDC80 kinetochore complex | Alias Symbol: FLJ90806 | ||
| Type: protein-coding gene | Cytoband: 19p13.2 | ||
| Entrez ID: 147841 | HGNC ID: HGNC:26913 | Ensembl Gene: ENSG00000161888 | OMIM ID: 609394 |
| Drug and gene relationship at DGIdb | |||
Expression of SPC24:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SPC24 | 147841 | 235572_at | 0.6917 | 0.2281 | |
| GSE26886 | SPC24 | 147841 | 235572_at | 0.3821 | 0.1503 | |
| GSE45670 | SPC24 | 147841 | 235572_at | 0.9151 | 0.0001 | |
| GSE53622 | SPC24 | 147841 | 112294 | 1.0804 | 0.0000 | |
| GSE53624 | SPC24 | 147841 | 112294 | 1.4384 | 0.0000 | |
| GSE63941 | SPC24 | 147841 | 235572_at | 1.6820 | 0.0065 | |
| GSE77861 | SPC24 | 147841 | 235572_at | 0.3600 | 0.1032 | |
| GSE97050 | SPC24 | 147841 | A_24_P314571 | 1.0046 | 0.1399 | |
| SRP007169 | SPC24 | 147841 | RNAseq | 1.3699 | 0.0039 | |
| SRP064894 | SPC24 | 147841 | RNAseq | 2.0964 | 0.0000 | |
| SRP133303 | SPC24 | 147841 | RNAseq | 0.5535 | 0.0000 | |
| SRP159526 | SPC24 | 147841 | RNAseq | 1.6109 | 0.0006 | |
| SRP193095 | SPC24 | 147841 | RNAseq | 0.4414 | 0.0000 | |
| SRP219564 | SPC24 | 147841 | RNAseq | 1.7468 | 0.0005 | |
| TCGA | SPC24 | 147841 | RNAseq | 1.9337 | 0.0000 |
Upregulated datasets: 8; Downregulated datasets: 0.
Survival by SPC24 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SPC24:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SPC24 | 147841 | 4 | 2 | 24 | |
| GSE20123 | SPC24 | 147841 | 3 | 1 | 26 | |
| GSE43470 | SPC24 | 147841 | 2 | 6 | 35 | |
| GSE46452 | SPC24 | 147841 | 47 | 1 | 11 | |
| GSE47630 | SPC24 | 147841 | 4 | 7 | 29 | |
| GSE54993 | SPC24 | 147841 | 16 | 3 | 51 | |
| GSE54994 | SPC24 | 147841 | 6 | 13 | 34 | |
| GSE60625 | SPC24 | 147841 | 9 | 0 | 2 | |
| GSE74703 | SPC24 | 147841 | 2 | 4 | 30 | |
| GSE74704 | SPC24 | 147841 | 0 | 1 | 19 | |
| TCGA | SPC24 | 147841 | 16 | 13 | 67 |
Total number of gains: 109; Total number of losses: 51; Total Number of normals: 328.
Somatic mutations of SPC24:
Generating mutation plots.
Highly correlated genes for SPC24:
Showing top 20/1228 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SPC24 | RNASEH2A | 0.850915 | 7 | 0 | 7 |
| SPC24 | CENPO | 0.806987 | 4 | 0 | 4 |
| SPC24 | STIL | 0.80342 | 7 | 0 | 7 |
| SPC24 | CENPN | 0.799875 | 7 | 0 | 7 |
| SPC24 | CDK1 | 0.797609 | 7 | 0 | 7 |
| SPC24 | AURKB | 0.795442 | 8 | 0 | 8 |
| SPC24 | CCNA2 | 0.787972 | 7 | 0 | 7 |
| SPC24 | KIF2C | 0.784804 | 8 | 0 | 8 |
| SPC24 | IQGAP3 | 0.784047 | 6 | 0 | 6 |
| SPC24 | TPX2 | 0.78097 | 8 | 0 | 8 |
| SPC24 | HMMR | 0.780389 | 7 | 0 | 7 |
| SPC24 | CHAF1A | 0.775581 | 8 | 0 | 8 |
| SPC24 | KIFC1 | 0.774415 | 8 | 0 | 7 |
| SPC24 | UHRF1 | 0.77318 | 8 | 0 | 8 |
| SPC24 | UBE2C | 0.769848 | 8 | 0 | 8 |
| SPC24 | TRIP13 | 0.769762 | 8 | 0 | 8 |
| SPC24 | CDCA8 | 0.769613 | 8 | 0 | 8 |
| SPC24 | NEK2 | 0.765442 | 8 | 0 | 7 |
| SPC24 | DTL | 0.763722 | 8 | 0 | 8 |
| SPC24 | CDCA3 | 0.759965 | 8 | 0 | 8 |
For details and further investigation, click here
