FAM217A

 

Full name: family with sequence similarity 217 member A Alias Symbol: MGC43581
Type: protein-coding gene Cytoband: 6p25.2
Entrez ID: 222826 HGNC ID: HGNC:21362 Ensembl Gene: ENSG00000145975 OMIM ID: 
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of FAM217A:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 FAM217A 222826 237619_at 0.1408 0.5431
GSE26886 FAM217A 222826 237619_at 0.0997 0.2517
GSE45670 FAM217A 222826 237619_at -0.0024 0.9819
GSE53622 FAM217A 222826 92191 0.0806 0.5571
GSE53624 FAM217A 222826 92191 -0.0496 0.5991
GSE63941 FAM217A 222826 237619_at 0.0696 0.6572
GSE77861 FAM217A 222826 237619_at 0.0366 0.7317

Upregulated datasets: 0; Downregulated datasets: 0.  


 

Survival by FAM217A expression:

 

GSE53622GSE53624

 

Note: Click image to view full size file.  


Copy number change of FAM217A:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 FAM217A 222826 4 5 21
GSE20123 FAM217A 222826 4 5 21
GSE43470 FAM217A 222826 8 2 33
GSE46452 FAM217A 222826 1 10 48
GSE47630 FAM217A 222826 7 8 25
GSE54993 FAM217A 222826 1 1 68
GSE54994 FAM217A 222826 10 3 40
GSE60625 FAM217A 222826 0 1 10
GSE74703 FAM217A 222826 7 2 27
GSE74704 FAM217A 222826 2 2 16
TCGA FAM217A 222826 16 29 51

Total number of gains: 60; Total number of losses: 68; Total Number of normals: 360.  


 

Somatic mutations of FAM217A:

 

Generating mutation plots.

 

Highly correlated genes for FAM217A:

 

Showing top 20/41 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
FAM217AP4HA30.686894303
FAM217AZFP920.681823303
FAM217AKCNS10.664612303
FAM217AGLP1R0.664068303
FAM217AGPR210.657746303
FAM217ATCTE30.638206303
FAM217ACRYGA0.623316303
FAM217ACNGB30.621858403
FAM217ACD1010.615873404
FAM217ASERPINA90.615249303
FAM217AGNAO10.610504403
FAM217ALINC009280.605172403
FAM217AKDM6B0.596568303
FAM217ABTG40.591452303
FAM217AGAMT0.590697303
FAM217APRKAR1B0.585144303
FAM217ALINC005200.58242403
FAM217ASLC8A30.582211403
FAM217AROPN1L0.581906303
FAM217AFAM219A0.580338303

For details and further investigation, click here