| Full name: guanidinoacetate N-methyltransferase | Alias Symbol: PIG2|TP53I2 | ||
| Type: protein-coding gene | Cytoband: 19p13.3 | ||
| Entrez ID: 2593 | HGNC ID: HGNC:4136 | Ensembl Gene: ENSG00000130005 | OMIM ID: 601240 |
| Drug and gene relationship at DGIdb | |||
Expression of GAMT:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GAMT | 2593 | 1552473_at | 0.1600 | 0.7748 | |
| GSE20347 | GAMT | 2593 | 205354_at | -0.0624 | 0.7748 | |
| GSE23400 | GAMT | 2593 | 205354_at | -0.0657 | 0.3433 | |
| GSE26886 | GAMT | 2593 | 1552474_a_at | 0.3401 | 0.0558 | |
| GSE29001 | GAMT | 2593 | 205354_at | 0.0343 | 0.9018 | |
| GSE38129 | GAMT | 2593 | 205354_at | -0.0912 | 0.6234 | |
| GSE45670 | GAMT | 2593 | 1552473_at | 0.1639 | 0.1003 | |
| GSE53622 | GAMT | 2593 | 76281 | 0.0756 | 0.3333 | |
| GSE53624 | GAMT | 2593 | 76281 | 0.1788 | 0.0191 | |
| GSE63941 | GAMT | 2593 | 1552474_a_at | 0.7198 | 0.0955 | |
| GSE77861 | GAMT | 2593 | 1552474_a_at | 0.0893 | 0.7282 | |
| GSE97050 | GAMT | 2593 | A_24_P19228 | -0.3550 | 0.4106 | |
| SRP007169 | GAMT | 2593 | RNAseq | -0.6568 | 0.2312 | |
| SRP008496 | GAMT | 2593 | RNAseq | -0.3885 | 0.3961 | |
| SRP064894 | GAMT | 2593 | RNAseq | 0.2612 | 0.5851 | |
| SRP133303 | GAMT | 2593 | RNAseq | -0.5105 | 0.0145 | |
| SRP159526 | GAMT | 2593 | RNAseq | 0.8642 | 0.0091 | |
| SRP193095 | GAMT | 2593 | RNAseq | 0.1815 | 0.3813 | |
| SRP219564 | GAMT | 2593 | RNAseq | -0.4160 | 0.5678 | |
| TCGA | GAMT | 2593 | RNAseq | -0.2647 | 0.0775 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by GAMT expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GAMT:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GAMT | 2593 | 4 | 6 | 20 | |
| GSE20123 | GAMT | 2593 | 4 | 5 | 21 | |
| GSE43470 | GAMT | 2593 | 1 | 11 | 31 | |
| GSE46452 | GAMT | 2593 | 47 | 1 | 11 | |
| GSE47630 | GAMT | 2593 | 5 | 7 | 28 | |
| GSE54993 | GAMT | 2593 | 15 | 4 | 51 | |
| GSE54994 | GAMT | 2593 | 8 | 15 | 30 | |
| GSE60625 | GAMT | 2593 | 9 | 0 | 2 | |
| GSE74703 | GAMT | 2593 | 1 | 8 | 27 | |
| GSE74704 | GAMT | 2593 | 3 | 3 | 14 | |
| TCGA | GAMT | 2593 | 7 | 25 | 64 |
Total number of gains: 104; Total number of losses: 85; Total Number of normals: 299.
Somatic mutations of GAMT:
Generating mutation plots.
Highly correlated genes for GAMT:
Showing top 20/57 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GAMT | PLA2G5 | 0.72048 | 3 | 0 | 3 |
| GAMT | CHD3 | 0.715426 | 3 | 0 | 3 |
| GAMT | IGSF10 | 0.706832 | 3 | 0 | 3 |
| GAMT | TNP2 | 0.669877 | 3 | 0 | 3 |
| GAMT | NPB | 0.667068 | 4 | 0 | 3 |
| GAMT | FN3K | 0.665322 | 3 | 0 | 3 |
| GAMT | THAP8 | 0.659385 | 3 | 0 | 3 |
| GAMT | GRIN3B | 0.654701 | 3 | 0 | 3 |
| GAMT | FAM167B | 0.634061 | 4 | 0 | 3 |
| GAMT | MEIS3 | 0.622304 | 3 | 0 | 3 |
| GAMT | PCGF2 | 0.621641 | 3 | 0 | 3 |
| GAMT | TPSG1 | 0.615162 | 3 | 0 | 3 |
| GAMT | ZDHHC22 | 0.599109 | 3 | 0 | 3 |
| GAMT | USF2 | 0.592114 | 4 | 0 | 3 |
| GAMT | FAM217A | 0.590697 | 3 | 0 | 3 |
| GAMT | SEMA4G | 0.588655 | 4 | 0 | 3 |
| GAMT | CSF3R | 0.588268 | 4 | 0 | 3 |
| GAMT | TMEM173 | 0.586327 | 3 | 0 | 3 |
| GAMT | GCLC | 0.5848 | 3 | 0 | 3 |
| GAMT | NME4 | 0.583903 | 3 | 0 | 3 |
For details and further investigation, click here
