PRKAR1B

 

Full name: protein kinase cAMP-dependent type I regulatory subunit beta Alias Symbol: 
Type: protein-coding gene Cytoband: 7p22.3
Entrez ID: 5575 HGNC ID: HGNC:9390 Ensembl Gene: ENSG00000188191 OMIM ID: 176911
Drug and gene relationship at DGIdb

 

PRKAR1B involved pathways:

KEGG pathway Description View
hsa04910Insulin signaling pathway

 

Expression of PRKAR1B:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 PRKAR1B 5575 212559_at 0.5451 0.1853
GSE20347 PRKAR1B 5575 212555_at 0.0631 0.3393
GSE23400 PRKAR1B 5575 212555_at 0.0438 0.2406
GSE26886 PRKAR1B 5575 212555_at 0.0997 0.5772
GSE29001 PRKAR1B 5575 212555_at -0.0645 0.6946
GSE38129 PRKAR1B 5575 212555_at 0.0796 0.2569
GSE45670 PRKAR1B 5575 212555_at 0.1303 0.1703
GSE53622 PRKAR1B 5575 46560 0.0616 0.2742
GSE53624 PRKAR1B 5575 46560 -0.3317 0.0073
GSE63941 PRKAR1B 5575 212555_at 0.7628 0.0110
GSE77861 PRKAR1B 5575 212555_at 0.0199 0.8577
GSE97050 PRKAR1B 5575 A_23_P83599 0.0223 0.9421
SRP007169 PRKAR1B 5575 RNAseq 0.7571 0.1715
SRP008496 PRKAR1B 5575 RNAseq 1.4088 0.0023
SRP064894 PRKAR1B 5575 RNAseq 0.9804 0.0024
SRP133303 PRKAR1B 5575 RNAseq 0.6916 0.0043
SRP159526 PRKAR1B 5575 RNAseq 0.7881 0.1539
SRP193095 PRKAR1B 5575 RNAseq 0.6036 0.0002
SRP219564 PRKAR1B 5575 RNAseq 0.5253 0.3634
TCGA PRKAR1B 5575 RNAseq 0.0985 0.3054

Upregulated datasets: 1; Downregulated datasets: 0.  

 

Survival by PRKAR1B expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of PRKAR1B:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 PRKAR1B 5575 14 0 16
GSE20123 PRKAR1B 5575 14 0 16
GSE43470 PRKAR1B 5575 6 2 35
GSE46452 PRKAR1B 5575 13 1 45
GSE47630 PRKAR1B 5575 12 1 27
GSE54993 PRKAR1B 5575 3 10 57
GSE54994 PRKAR1B 5575 20 3 30
GSE60625 PRKAR1B 5575 0 0 11
GSE74703 PRKAR1B 5575 6 1 29
GSE74704 PRKAR1B 5575 9 0 11
TCGA PRKAR1B 5575 56 6 34

Total number of gains: 153; Total number of losses: 24; Total Number of normals: 311.  

 

Somatic mutations of PRKAR1B:

 

Generating mutation plots.

 

Highly correlated genes for PRKAR1B:

 

Showing top 20/555 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
PRKAR1BVIPR20.813395303
PRKAR1BSEC14L40.795989303
PRKAR1BMUC80.785659404
PRKAR1BCCDC1420.783529303
PRKAR1BPGC0.772999303
PRKAR1BC4BPA0.75783303
PRKAR1BFOLR30.757155303
PRKAR1BNEUROG10.755529303
PRKAR1BNPY2R0.754479303
PRKAR1BHGD0.751031303
PRKAR1BPRODH20.750323403
PRKAR1BDCDC10.750163303
PRKAR1BCPNE60.736088404
PRKAR1BCLTCL10.732822404
PRKAR1BDNAI10.730278404
PRKAR1BLILRA10.729384303
PRKAR1BC2CD4D0.724234303
PRKAR1BMARVELD30.723895303
PRKAR1BSPTBN50.719789303
PRKAR1BIGHMBP20.717353403

For details and further investigation, click here