| Full name: FAT atypical cadherin 4 | Alias Symbol: CDHF14|FAT-J|CDHR11 | ||
| Type: protein-coding gene | Cytoband: 4q28.1 | ||
| Entrez ID: 79633 | HGNC ID: HGNC:23109 | Ensembl Gene: ENSG00000196159 | OMIM ID: 612411 |
| Drug and gene relationship at DGIdb | |||
Expression of FAT4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | FAT4 | 79633 | 219427_at | -1.3914 | 0.1227 | |
| GSE20347 | FAT4 | 79633 | 219427_at | -0.1482 | 0.2299 | |
| GSE23400 | FAT4 | 79633 | 219427_at | -0.1730 | 0.0108 | |
| GSE26886 | FAT4 | 79633 | 219427_at | 0.0142 | 0.9384 | |
| GSE29001 | FAT4 | 79633 | 219427_at | -0.2649 | 0.1590 | |
| GSE38129 | FAT4 | 79633 | 219427_at | -0.5717 | 0.0515 | |
| GSE45670 | FAT4 | 79633 | 219427_at | -1.7371 | 0.0000 | |
| GSE53622 | FAT4 | 79633 | 40313 | -0.1387 | 0.0977 | |
| GSE53624 | FAT4 | 79633 | 40313 | -0.2644 | 0.0000 | |
| GSE63941 | FAT4 | 79633 | 219427_at | -5.1241 | 0.0000 | |
| GSE77861 | FAT4 | 79633 | 219427_at | 0.0919 | 0.4301 | |
| GSE97050 | FAT4 | 79633 | A_33_P3374878 | -0.3497 | 0.2585 | |
| SRP007169 | FAT4 | 79633 | RNAseq | 1.8843 | 0.0006 | |
| SRP008496 | FAT4 | 79633 | RNAseq | 2.5405 | 0.0000 | |
| SRP064894 | FAT4 | 79633 | RNAseq | -0.2477 | 0.5856 | |
| SRP133303 | FAT4 | 79633 | RNAseq | -0.5677 | 0.0712 | |
| SRP159526 | FAT4 | 79633 | RNAseq | -0.4816 | 0.2337 | |
| SRP193095 | FAT4 | 79633 | RNAseq | 0.6984 | 0.0256 | |
| SRP219564 | FAT4 | 79633 | RNAseq | -0.4355 | 0.6195 | |
| TCGA | FAT4 | 79633 | RNAseq | -0.7840 | 0.0000 |
Upregulated datasets: 2; Downregulated datasets: 2.
Survival by FAT4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of FAT4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | FAT4 | 79633 | 0 | 12 | 18 | |
| GSE20123 | FAT4 | 79633 | 0 | 12 | 18 | |
| GSE43470 | FAT4 | 79633 | 0 | 14 | 29 | |
| GSE46452 | FAT4 | 79633 | 1 | 36 | 22 | |
| GSE47630 | FAT4 | 79633 | 0 | 22 | 18 | |
| GSE54993 | FAT4 | 79633 | 9 | 0 | 61 | |
| GSE54994 | FAT4 | 79633 | 1 | 11 | 41 | |
| GSE60625 | FAT4 | 79633 | 0 | 1 | 10 | |
| GSE74703 | FAT4 | 79633 | 0 | 12 | 24 | |
| GSE74704 | FAT4 | 79633 | 0 | 6 | 14 | |
| TCGA | FAT4 | 79633 | 8 | 36 | 52 |
Total number of gains: 19; Total number of losses: 162; Total Number of normals: 307.
Somatic mutations of FAT4:
Generating mutation plots.
Highly correlated genes for FAT4:
Showing top 20/610 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| FAT4 | FAM13C | 0.844392 | 3 | 0 | 3 |
| FAT4 | TMEM178A | 0.816224 | 3 | 0 | 3 |
| FAT4 | SLC4A4 | 0.809358 | 3 | 0 | 3 |
| FAT4 | KCNT2 | 0.805729 | 3 | 0 | 3 |
| FAT4 | FIBIN | 0.801871 | 4 | 0 | 4 |
| FAT4 | DNM3OS | 0.791712 | 3 | 0 | 3 |
| FAT4 | KBTBD11 | 0.790111 | 3 | 0 | 3 |
| FAT4 | ZNF667-AS1 | 0.77702 | 3 | 0 | 3 |
| FAT4 | LINC01279 | 0.769965 | 4 | 0 | 3 |
| FAT4 | MRVI1 | 0.769666 | 6 | 0 | 5 |
| FAT4 | BEND5 | 0.765498 | 3 | 0 | 3 |
| FAT4 | CNTN4 | 0.762606 | 4 | 0 | 3 |
| FAT4 | LIFR | 0.755398 | 3 | 0 | 3 |
| FAT4 | ZFPM2 | 0.742139 | 7 | 0 | 6 |
| FAT4 | MOB2 | 0.741714 | 3 | 0 | 3 |
| FAT4 | LAMA2 | 0.739887 | 9 | 0 | 7 |
| FAT4 | ZC3H6 | 0.73982 | 3 | 0 | 3 |
| FAT4 | MFAP4 | 0.735262 | 9 | 0 | 8 |
| FAT4 | LDB2 | 0.734602 | 12 | 0 | 12 |
| FAT4 | RCAN2 | 0.733464 | 10 | 0 | 7 |
For details and further investigation, click here
