| Full name: solute carrier family 4 member 4 | Alias Symbol: NBC1|HNBC1|NBC2|pNBC|hhNMC | ||
| Type: protein-coding gene | Cytoband: 4q13.3 | ||
| Entrez ID: 8671 | HGNC ID: HGNC:11030 | Ensembl Gene: ENSG00000080493 | OMIM ID: 603345 |
| Drug and gene relationship at DGIdb | |||
Expression of SLC4A4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SLC4A4 | 8671 | 203908_at | -1.1995 | 0.0777 | |
| GSE20347 | SLC4A4 | 8671 | 210739_x_at | -0.0931 | 0.5631 | |
| GSE23400 | SLC4A4 | 8671 | 210739_x_at | -0.1688 | 0.0003 | |
| GSE26886 | SLC4A4 | 8671 | 203908_at | -0.6889 | 0.3344 | |
| GSE29001 | SLC4A4 | 8671 | 210739_x_at | -0.3746 | 0.1362 | |
| GSE38129 | SLC4A4 | 8671 | 210739_x_at | -0.2853 | 0.0173 | |
| GSE45670 | SLC4A4 | 8671 | 203908_at | -2.7456 | 0.0000 | |
| GSE53622 | SLC4A4 | 8671 | 36054 | -2.7862 | 0.0000 | |
| GSE53624 | SLC4A4 | 8671 | 36054 | -3.0391 | 0.0000 | |
| GSE63941 | SLC4A4 | 8671 | 203908_at | -6.2154 | 0.0000 | |
| GSE77861 | SLC4A4 | 8671 | 211494_s_at | -0.1155 | 0.4710 | |
| GSE97050 | SLC4A4 | 8671 | A_32_P358887 | -0.1443 | 0.5913 | |
| SRP007169 | SLC4A4 | 8671 | RNAseq | -3.6647 | 0.0000 | |
| SRP064894 | SLC4A4 | 8671 | RNAseq | -2.5123 | 0.0000 | |
| SRP133303 | SLC4A4 | 8671 | RNAseq | -2.5618 | 0.0000 | |
| SRP193095 | SLC4A4 | 8671 | RNAseq | -1.5217 | 0.0318 | |
| TCGA | SLC4A4 | 8671 | RNAseq | -2.4814 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 9.
Survival by SLC4A4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SLC4A4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SLC4A4 | 8671 | 1 | 11 | 18 | |
| GSE20123 | SLC4A4 | 8671 | 1 | 11 | 18 | |
| GSE43470 | SLC4A4 | 8671 | 0 | 13 | 30 | |
| GSE46452 | SLC4A4 | 8671 | 2 | 35 | 22 | |
| GSE47630 | SLC4A4 | 8671 | 1 | 19 | 20 | |
| GSE54993 | SLC4A4 | 8671 | 7 | 0 | 63 | |
| GSE54994 | SLC4A4 | 8671 | 1 | 9 | 43 | |
| GSE60625 | SLC4A4 | 8671 | 0 | 0 | 11 | |
| GSE74703 | SLC4A4 | 8671 | 0 | 11 | 25 | |
| GSE74704 | SLC4A4 | 8671 | 1 | 6 | 13 | |
| TCGA | SLC4A4 | 8671 | 17 | 28 | 51 |
Total number of gains: 31; Total number of losses: 143; Total Number of normals: 314.
Somatic mutations of SLC4A4:
Generating mutation plots.
Highly correlated genes for SLC4A4:
Showing top 20/1500 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SLC4A4 | TMEM100 | 0.866841 | 5 | 0 | 5 |
| SLC4A4 | ABCA8 | 0.842194 | 6 | 0 | 6 |
| SLC4A4 | PEG3 | 0.832683 | 4 | 0 | 4 |
| SLC4A4 | ITGA1 | 0.824151 | 4 | 0 | 4 |
| SLC4A4 | TCF21 | 0.81637 | 6 | 0 | 6 |
| SLC4A4 | RCAN2 | 0.815655 | 6 | 0 | 6 |
| SLC4A4 | FAT4 | 0.809358 | 3 | 0 | 3 |
| SLC4A4 | GPD1L | 0.80199 | 5 | 0 | 5 |
| SLC4A4 | LINC01279 | 0.797971 | 3 | 0 | 3 |
| SLC4A4 | SORCS1 | 0.793823 | 4 | 0 | 4 |
| SLC4A4 | LRRK2 | 0.792746 | 6 | 0 | 6 |
| SLC4A4 | FENDRR | 0.790173 | 5 | 0 | 5 |
| SLC4A4 | CYP4V2 | 0.784183 | 4 | 0 | 4 |
| SLC4A4 | PARD3B | 0.778164 | 5 | 0 | 5 |
| SLC4A4 | PDE5A | 0.777026 | 8 | 0 | 8 |
| SLC4A4 | XKR4 | 0.771397 | 5 | 0 | 5 |
| SLC4A4 | MYOCD | 0.768032 | 6 | 0 | 6 |
| SLC4A4 | C7 | 0.764548 | 6 | 0 | 5 |
| SLC4A4 | SVEP1 | 0.762504 | 5 | 0 | 4 |
| SLC4A4 | OGN | 0.760692 | 6 | 0 | 6 |
For details and further investigation, click here
