| Full name: fibrillarin | Alias Symbol: RNU3IP1|FLRN|FIB|Nop1 | ||
| Type: protein-coding gene | Cytoband: 19q13.2 | ||
| Entrez ID: 2091 | HGNC ID: HGNC:3599 | Ensembl Gene: ENSG00000105202 | OMIM ID: 134795 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of FBL:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | FBL | 2091 | 211623_s_at | 0.1098 | 0.8152 | |
| GSE20347 | FBL | 2091 | 211623_s_at | 0.2566 | 0.1952 | |
| GSE23400 | FBL | 2091 | 211623_s_at | 0.4591 | 0.0000 | |
| GSE26886 | FBL | 2091 | 211623_s_at | -0.0332 | 0.8859 | |
| GSE29001 | FBL | 2091 | 211623_s_at | 0.3491 | 0.5341 | |
| GSE38129 | FBL | 2091 | 211623_s_at | 0.5416 | 0.0003 | |
| GSE45670 | FBL | 2091 | 211623_s_at | -0.1165 | 0.5207 | |
| GSE53622 | FBL | 2091 | 38187 | -0.0913 | 0.2519 | |
| GSE53624 | FBL | 2091 | 38187 | 0.3471 | 0.0000 | |
| GSE63941 | FBL | 2091 | 211623_s_at | 1.7350 | 0.0011 | |
| GSE77861 | FBL | 2091 | 211623_s_at | 0.3817 | 0.2947 | |
| GSE97050 | FBL | 2091 | A_23_P78888 | 0.1143 | 0.7397 | |
| SRP007169 | FBL | 2091 | RNAseq | -0.1739 | 0.5876 | |
| SRP008496 | FBL | 2091 | RNAseq | -0.4206 | 0.0477 | |
| SRP064894 | FBL | 2091 | RNAseq | 0.3436 | 0.3138 | |
| SRP133303 | FBL | 2091 | RNAseq | 0.2313 | 0.3070 | |
| SRP159526 | FBL | 2091 | RNAseq | 0.2588 | 0.2794 | |
| SRP193095 | FBL | 2091 | RNAseq | -0.1622 | 0.2522 | |
| SRP219564 | FBL | 2091 | RNAseq | 0.1106 | 0.7335 | |
| TCGA | FBL | 2091 | RNAseq | 0.2517 | 0.0000 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by FBL expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of FBL:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | FBL | 2091 | 7 | 4 | 19 | |
| GSE20123 | FBL | 2091 | 7 | 3 | 20 | |
| GSE43470 | FBL | 2091 | 3 | 11 | 29 | |
| GSE46452 | FBL | 2091 | 48 | 1 | 10 | |
| GSE47630 | FBL | 2091 | 9 | 5 | 26 | |
| GSE54993 | FBL | 2091 | 17 | 3 | 50 | |
| GSE54994 | FBL | 2091 | 8 | 9 | 36 | |
| GSE60625 | FBL | 2091 | 9 | 0 | 2 | |
| GSE74703 | FBL | 2091 | 3 | 7 | 26 | |
| GSE74704 | FBL | 2091 | 7 | 1 | 12 | |
| TCGA | FBL | 2091 | 14 | 16 | 66 |
Total number of gains: 132; Total number of losses: 60; Total Number of normals: 296.
Somatic mutations of FBL:
Generating mutation plots.
Highly correlated genes for FBL:
Showing top 20/666 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| FBL | GLCCI1 | 0.767942 | 3 | 0 | 3 |
| FBL | HNRNPUL2 | 0.762971 | 3 | 0 | 3 |
| FBL | STRBP | 0.755163 | 3 | 0 | 3 |
| FBL | ORAI1 | 0.752473 | 3 | 0 | 3 |
| FBL | MRI1 | 0.749743 | 3 | 0 | 3 |
| FBL | LAPTM5 | 0.731541 | 3 | 0 | 3 |
| FBL | RASAL3 | 0.728598 | 3 | 0 | 3 |
| FBL | NUCKS1 | 0.710431 | 3 | 0 | 3 |
| FBL | IFRD2 | 0.709493 | 3 | 0 | 3 |
| FBL | ANP32A | 0.707722 | 5 | 0 | 5 |
| FBL | WDR81 | 0.701093 | 3 | 0 | 3 |
| FBL | CLDN15 | 0.700379 | 3 | 0 | 3 |
| FBL | EXOC6 | 0.698498 | 3 | 0 | 3 |
| FBL | ATP11C | 0.695041 | 4 | 0 | 3 |
| FBL | HHEX | 0.692643 | 3 | 0 | 3 |
| FBL | HCLS1 | 0.682171 | 4 | 0 | 3 |
| FBL | SMCR8 | 0.681762 | 3 | 0 | 3 |
| FBL | HLA-DQB1 | 0.681668 | 4 | 0 | 4 |
| FBL | GPR160 | 0.678057 | 4 | 0 | 3 |
| FBL | N4BP2L1 | 0.67738 | 3 | 0 | 3 |
For details and further investigation, click here
