| Full name: RAS protein activator like 3 | Alias Symbol: FLJ21438 | ||
| Type: protein-coding gene | Cytoband: 19p13.12 | ||
| Entrez ID: 64926 | HGNC ID: HGNC:26129 | Ensembl Gene: ENSG00000105122 | OMIM ID: 616561 |
| Drug and gene relationship at DGIdb | |||
RASAL3 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04014 | Ras signaling pathway |
Expression of RASAL3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RASAL3 | 64926 | 228677_s_at | 0.4655 | 0.4399 | |
| GSE26886 | RASAL3 | 64926 | 228677_s_at | 0.1328 | 0.5879 | |
| GSE45670 | RASAL3 | 64926 | 228677_s_at | -0.0588 | 0.7667 | |
| GSE53622 | RASAL3 | 64926 | 13516 | 0.0747 | 0.4613 | |
| GSE53624 | RASAL3 | 64926 | 13516 | -0.0431 | 0.5282 | |
| GSE63941 | RASAL3 | 64926 | 228677_s_at | 0.4032 | 0.0795 | |
| GSE77861 | RASAL3 | 64926 | 228677_s_at | -0.0311 | 0.8993 | |
| GSE97050 | RASAL3 | 64926 | A_23_P79069 | 0.1861 | 0.6797 | |
| SRP064894 | RASAL3 | 64926 | RNAseq | 0.3915 | 0.1632 | |
| SRP133303 | RASAL3 | 64926 | RNAseq | -0.2995 | 0.1410 | |
| SRP159526 | RASAL3 | 64926 | RNAseq | -1.0637 | 0.1046 | |
| SRP193095 | RASAL3 | 64926 | RNAseq | 0.0892 | 0.6893 | |
| SRP219564 | RASAL3 | 64926 | RNAseq | 0.3659 | 0.2929 | |
| TCGA | RASAL3 | 64926 | RNAseq | -0.0340 | 0.8331 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by RASAL3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RASAL3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RASAL3 | 64926 | 4 | 2 | 24 | |
| GSE20123 | RASAL3 | 64926 | 3 | 1 | 26 | |
| GSE43470 | RASAL3 | 64926 | 2 | 6 | 35 | |
| GSE46452 | RASAL3 | 64926 | 47 | 1 | 11 | |
| GSE47630 | RASAL3 | 64926 | 4 | 7 | 29 | |
| GSE54993 | RASAL3 | 64926 | 15 | 4 | 51 | |
| GSE54994 | RASAL3 | 64926 | 6 | 14 | 33 | |
| GSE60625 | RASAL3 | 64926 | 9 | 0 | 2 | |
| GSE74703 | RASAL3 | 64926 | 2 | 4 | 30 | |
| GSE74704 | RASAL3 | 64926 | 0 | 1 | 19 | |
| TCGA | RASAL3 | 64926 | 20 | 10 | 66 |
Total number of gains: 112; Total number of losses: 50; Total Number of normals: 326.
Somatic mutations of RASAL3:
Generating mutation plots.
Highly correlated genes for RASAL3:
Showing top 20/293 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RASAL3 | HLA-A | 0.746255 | 3 | 0 | 3 |
| RASAL3 | FBL | 0.728598 | 3 | 0 | 3 |
| RASAL3 | UBA1 | 0.722961 | 3 | 0 | 3 |
| RASAL3 | CALR | 0.718783 | 3 | 0 | 3 |
| RASAL3 | UBASH3A | 0.716067 | 5 | 0 | 5 |
| RASAL3 | PLCB2 | 0.714752 | 4 | 0 | 4 |
| RASAL3 | HLA-DMA | 0.713291 | 5 | 0 | 5 |
| RASAL3 | PLD3 | 0.712997 | 3 | 0 | 3 |
| RASAL3 | CD6 | 0.708467 | 6 | 0 | 6 |
| RASAL3 | APOL2 | 0.700852 | 4 | 0 | 4 |
| RASAL3 | SLC35A4 | 0.699804 | 3 | 0 | 3 |
| RASAL3 | MIER2 | 0.699259 | 3 | 0 | 3 |
| RASAL3 | BCAS4 | 0.697855 | 3 | 0 | 3 |
| RASAL3 | FXYD3 | 0.6978 | 3 | 0 | 3 |
| RASAL3 | BIN2 | 0.696105 | 3 | 0 | 3 |
| RASAL3 | CDCA7 | 0.694673 | 3 | 0 | 3 |
| RASAL3 | C3AR1 | 0.693569 | 3 | 0 | 3 |
| RASAL3 | THEMIS2 | 0.690317 | 3 | 0 | 3 |
| RASAL3 | ARHGDIB | 0.690216 | 5 | 0 | 5 |
| RASAL3 | TTC38 | 0.688796 | 3 | 0 | 3 |
For details and further investigation, click here
