| Full name: claudin 15 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 7q22.1 | ||
| Entrez ID: 24146 | HGNC ID: HGNC:2036 | Ensembl Gene: ENSG00000106404 | OMIM ID: 615778 |
| Drug and gene relationship at DGIdb | |||
CLDN15 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04530 | Tight junction |
Expression of CLDN15:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CLDN15 | 24146 | 219640_at | 0.0534 | 0.9172 | |
| GSE20347 | CLDN15 | 24146 | 219640_at | 0.1512 | 0.0919 | |
| GSE23400 | CLDN15 | 24146 | 219640_at | 0.0917 | 0.0173 | |
| GSE26886 | CLDN15 | 24146 | 219640_at | 0.3648 | 0.0017 | |
| GSE29001 | CLDN15 | 24146 | 219640_at | -0.0339 | 0.8080 | |
| GSE38129 | CLDN15 | 24146 | 219640_at | 0.0811 | 0.3452 | |
| GSE45670 | CLDN15 | 24146 | 219640_at | 0.1886 | 0.1239 | |
| GSE53622 | CLDN15 | 24146 | 5755 | 0.2810 | 0.0001 | |
| GSE53624 | CLDN15 | 24146 | 5755 | 0.1821 | 0.0589 | |
| GSE63941 | CLDN15 | 24146 | 219640_at | 0.4787 | 0.1864 | |
| GSE77861 | CLDN15 | 24146 | 219640_at | 0.0934 | 0.4485 | |
| GSE97050 | CLDN15 | 24146 | A_23_P500886 | 0.3378 | 0.3101 | |
| SRP007169 | CLDN15 | 24146 | RNAseq | 0.8780 | 0.2343 | |
| SRP064894 | CLDN15 | 24146 | RNAseq | 0.7721 | 0.0046 | |
| SRP133303 | CLDN15 | 24146 | RNAseq | 0.2715 | 0.1103 | |
| SRP159526 | CLDN15 | 24146 | RNAseq | 0.0508 | 0.8761 | |
| SRP193095 | CLDN15 | 24146 | RNAseq | 0.4061 | 0.1130 | |
| SRP219564 | CLDN15 | 24146 | RNAseq | 1.0165 | 0.0454 | |
| TCGA | CLDN15 | 24146 | RNAseq | -0.0433 | 0.6738 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by CLDN15 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CLDN15:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CLDN15 | 24146 | 13 | 0 | 17 | |
| GSE20123 | CLDN15 | 24146 | 13 | 0 | 17 | |
| GSE43470 | CLDN15 | 24146 | 7 | 2 | 34 | |
| GSE46452 | CLDN15 | 24146 | 11 | 1 | 47 | |
| GSE47630 | CLDN15 | 24146 | 7 | 3 | 30 | |
| GSE54993 | CLDN15 | 24146 | 1 | 10 | 59 | |
| GSE54994 | CLDN15 | 24146 | 15 | 3 | 35 | |
| GSE60625 | CLDN15 | 24146 | 0 | 0 | 11 | |
| GSE74703 | CLDN15 | 24146 | 7 | 1 | 28 | |
| GSE74704 | CLDN15 | 24146 | 9 | 0 | 11 | |
| TCGA | CLDN15 | 24146 | 53 | 6 | 37 |
Total number of gains: 136; Total number of losses: 26; Total Number of normals: 326.
Somatic mutations of CLDN15:
Generating mutation plots.
Highly correlated genes for CLDN15:
Showing top 20/263 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CLDN15 | FBL | 0.700379 | 3 | 0 | 3 |
| CLDN15 | YDJC | 0.688563 | 4 | 0 | 3 |
| CLDN15 | SLC43A2 | 0.659291 | 3 | 0 | 3 |
| CLDN15 | SNAPC4 | 0.65542 | 7 | 0 | 7 |
| CLDN15 | CLDN6 | 0.654954 | 3 | 0 | 3 |
| CLDN15 | CNTROB | 0.653569 | 3 | 0 | 3 |
| CLDN15 | SLC9A1 | 0.643995 | 3 | 0 | 3 |
| CLDN15 | TOP1MT | 0.631712 | 3 | 0 | 3 |
| CLDN15 | CDCA4 | 0.62976 | 3 | 0 | 3 |
| CLDN15 | BCAR1 | 0.629674 | 3 | 0 | 3 |
| CLDN15 | ORAI1 | 0.629673 | 3 | 0 | 3 |
| CLDN15 | TBCB | 0.628037 | 4 | 0 | 4 |
| CLDN15 | PANX2 | 0.62532 | 5 | 0 | 4 |
| CLDN15 | ARHGEF19 | 0.624532 | 4 | 0 | 4 |
| CLDN15 | NOB1 | 0.621023 | 4 | 0 | 3 |
| CLDN15 | CABIN1 | 0.61957 | 5 | 0 | 4 |
| CLDN15 | WDR54 | 0.6179 | 3 | 0 | 3 |
| CLDN15 | TSPYL2 | 0.617607 | 5 | 0 | 4 |
| CLDN15 | TCL1A | 0.616068 | 4 | 0 | 3 |
| CLDN15 | HES4 | 0.615851 | 3 | 0 | 3 |
For details and further investigation, click here
