| Full name: F-box and leucine rich repeat protein 12 | Alias Symbol: FLJ20188|Fbl12 | ||
| Type: protein-coding gene | Cytoband: 19p13.2 | ||
| Entrez ID: 54850 | HGNC ID: HGNC:13611 | Ensembl Gene: ENSG00000127452 | OMIM ID: 609079 |
| Drug and gene relationship at DGIdb | |||
Expression of FBXL12:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | FBXL12 | 54850 | 220127_s_at | -0.0570 | 0.9263 | |
| GSE20347 | FBXL12 | 54850 | 220127_s_at | 0.2841 | 0.0181 | |
| GSE23400 | FBXL12 | 54850 | 220127_s_at | 0.2459 | 0.0000 | |
| GSE26886 | FBXL12 | 54850 | 220127_s_at | 0.5947 | 0.0010 | |
| GSE29001 | FBXL12 | 54850 | 220127_s_at | 0.0223 | 0.9084 | |
| GSE38129 | FBXL12 | 54850 | 220127_s_at | 0.1647 | 0.0692 | |
| GSE45670 | FBXL12 | 54850 | 220127_s_at | -0.0282 | 0.8677 | |
| GSE53622 | FBXL12 | 54850 | 7335 | 0.2319 | 0.0004 | |
| GSE53624 | FBXL12 | 54850 | 7335 | 0.3119 | 0.0000 | |
| GSE63941 | FBXL12 | 54850 | 220127_s_at | -0.2061 | 0.5362 | |
| GSE77861 | FBXL12 | 54850 | 220127_s_at | 0.5808 | 0.0036 | |
| GSE97050 | FBXL12 | 54850 | A_23_P78557 | 0.0526 | 0.8438 | |
| SRP007169 | FBXL12 | 54850 | RNAseq | 0.3043 | 0.4894 | |
| SRP008496 | FBXL12 | 54850 | RNAseq | 0.4471 | 0.1419 | |
| SRP064894 | FBXL12 | 54850 | RNAseq | 0.3299 | 0.0339 | |
| SRP133303 | FBXL12 | 54850 | RNAseq | 0.0976 | 0.5043 | |
| SRP159526 | FBXL12 | 54850 | RNAseq | -0.0657 | 0.7813 | |
| SRP193095 | FBXL12 | 54850 | RNAseq | 0.0248 | 0.8357 | |
| SRP219564 | FBXL12 | 54850 | RNAseq | 0.2574 | 0.4408 | |
| TCGA | FBXL12 | 54850 | RNAseq | -0.0227 | 0.6885 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by FBXL12 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of FBXL12:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | FBXL12 | 54850 | 4 | 2 | 24 | |
| GSE20123 | FBXL12 | 54850 | 3 | 1 | 26 | |
| GSE43470 | FBXL12 | 54850 | 3 | 6 | 34 | |
| GSE46452 | FBXL12 | 54850 | 47 | 1 | 11 | |
| GSE47630 | FBXL12 | 54850 | 5 | 7 | 28 | |
| GSE54993 | FBXL12 | 54850 | 16 | 3 | 51 | |
| GSE54994 | FBXL12 | 54850 | 7 | 13 | 33 | |
| GSE60625 | FBXL12 | 54850 | 9 | 0 | 2 | |
| GSE74703 | FBXL12 | 54850 | 3 | 4 | 29 | |
| GSE74704 | FBXL12 | 54850 | 0 | 1 | 19 | |
| TCGA | FBXL12 | 54850 | 12 | 17 | 67 |
Total number of gains: 109; Total number of losses: 55; Total Number of normals: 324.
Somatic mutations of FBXL12:
Generating mutation plots.
Highly correlated genes for FBXL12:
Showing top 20/167 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| FBXL12 | TIGD7 | 0.666676 | 3 | 0 | 3 |
| FBXL12 | FGFBP2 | 0.657096 | 4 | 0 | 4 |
| FBXL12 | EPCAM | 0.654765 | 4 | 0 | 3 |
| FBXL12 | CDCA7L | 0.651847 | 6 | 0 | 5 |
| FBXL12 | AP1M1 | 0.651008 | 6 | 0 | 6 |
| FBXL12 | TOX2 | 0.642801 | 4 | 0 | 4 |
| FBXL12 | NCAPH | 0.635948 | 4 | 0 | 3 |
| FBXL12 | FREM2 | 0.632594 | 3 | 0 | 3 |
| FBXL12 | TMEM120B | 0.632293 | 3 | 0 | 3 |
| FBXL12 | GTF2F1 | 0.62757 | 5 | 0 | 5 |
| FBXL12 | L3HYPDH | 0.625502 | 4 | 0 | 3 |
| FBXL12 | DTD2 | 0.623683 | 3 | 0 | 3 |
| FBXL12 | RILPL1 | 0.622364 | 3 | 0 | 3 |
| FBXL12 | NRK | 0.621901 | 4 | 0 | 3 |
| FBXL12 | ZCRB1 | 0.621491 | 4 | 0 | 3 |
| FBXL12 | TSC22D1-AS1 | 0.620647 | 4 | 0 | 4 |
| FBXL12 | BEND3 | 0.617611 | 4 | 0 | 4 |
| FBXL12 | SCAMP1-AS1 | 0.617032 | 4 | 0 | 4 |
| FBXL12 | ZNF559 | 0.612226 | 5 | 0 | 3 |
| FBXL12 | PCSK1N | 0.608662 | 3 | 0 | 3 |
For details and further investigation, click here
