| Full name: farnesyl diphosphate synthase | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 1q22 | ||
| Entrez ID: 2224 | HGNC ID: HGNC:3631 | Ensembl Gene: ENSG00000160752 | OMIM ID: 134629 |
| Drug and gene relationship at DGIdb | |||
FDPS involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05164 | Influenza A | |
| hsa05166 | HTLV-I infection |
Expression of FDPS:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | FDPS | 2224 | 201275_at | 0.4923 | 0.4454 | |
| GSE20347 | FDPS | 2224 | 201275_at | 0.0928 | 0.5293 | |
| GSE23400 | FDPS | 2224 | 201275_at | 0.2253 | 0.0199 | |
| GSE26886 | FDPS | 2224 | 201275_at | -0.5140 | 0.0249 | |
| GSE29001 | FDPS | 2224 | 201275_at | 0.2768 | 0.2520 | |
| GSE38129 | FDPS | 2224 | 201275_at | 0.4548 | 0.0028 | |
| GSE45670 | FDPS | 2224 | 201275_at | 0.3482 | 0.0236 | |
| GSE63941 | FDPS | 2224 | 201275_at | 0.5303 | 0.1400 | |
| GSE77861 | FDPS | 2224 | 201275_at | 0.1978 | 0.4296 | |
| GSE97050 | FDPS | 2224 | A_24_P114183 | 0.1825 | 0.4661 | |
| SRP007169 | FDPS | 2224 | RNAseq | -0.5481 | 0.0577 | |
| SRP008496 | FDPS | 2224 | RNAseq | -0.4450 | 0.0109 | |
| SRP064894 | FDPS | 2224 | RNAseq | 0.3476 | 0.1471 | |
| SRP133303 | FDPS | 2224 | RNAseq | 0.4795 | 0.0983 | |
| SRP159526 | FDPS | 2224 | RNAseq | 0.5958 | 0.0046 | |
| SRP193095 | FDPS | 2224 | RNAseq | -0.1183 | 0.3217 | |
| SRP219564 | FDPS | 2224 | RNAseq | -0.0009 | 0.9979 | |
| TCGA | FDPS | 2224 | RNAseq | 0.1278 | 0.0193 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by FDPS expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of FDPS:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | FDPS | 2224 | 14 | 0 | 16 | |
| GSE20123 | FDPS | 2224 | 13 | 0 | 17 | |
| GSE43470 | FDPS | 2224 | 7 | 3 | 33 | |
| GSE46452 | FDPS | 2224 | 2 | 1 | 56 | |
| GSE47630 | FDPS | 2224 | 14 | 0 | 26 | |
| GSE54993 | FDPS | 2224 | 0 | 4 | 66 | |
| GSE54994 | FDPS | 2224 | 16 | 0 | 37 | |
| GSE60625 | FDPS | 2224 | 0 | 0 | 11 | |
| GSE74703 | FDPS | 2224 | 7 | 2 | 27 | |
| GSE74704 | FDPS | 2224 | 6 | 0 | 14 | |
| TCGA | FDPS | 2224 | 38 | 2 | 56 |
Total number of gains: 117; Total number of losses: 12; Total Number of normals: 359.
Somatic mutations of FDPS:
Generating mutation plots.
Highly correlated genes for FDPS:
Showing top 20/551 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| FDPS | LANCL2 | 0.783309 | 4 | 0 | 4 |
| FDPS | ZC3H14 | 0.766977 | 3 | 0 | 3 |
| FDPS | COX16 | 0.751985 | 4 | 0 | 4 |
| FDPS | C1orf226 | 0.746488 | 3 | 0 | 3 |
| FDPS | CNOT10 | 0.742255 | 3 | 0 | 3 |
| FDPS | KIAA0586 | 0.738678 | 3 | 0 | 3 |
| FDPS | SCAMP1 | 0.718592 | 3 | 0 | 3 |
| FDPS | GRPEL1 | 0.715808 | 5 | 0 | 5 |
| FDPS | IPMK | 0.707149 | 3 | 0 | 3 |
| FDPS | C6orf141 | 0.699351 | 3 | 0 | 3 |
| FDPS | DRAP1 | 0.699318 | 4 | 0 | 3 |
| FDPS | STON2 | 0.698142 | 4 | 0 | 3 |
| FDPS | NPC2 | 0.696473 | 3 | 0 | 3 |
| FDPS | TMEM167A | 0.696399 | 5 | 0 | 4 |
| FDPS | TPM3 | 0.696282 | 4 | 0 | 4 |
| FDPS | RABGGTA | 0.695745 | 3 | 0 | 3 |
| FDPS | GMPR2 | 0.69554 | 4 | 0 | 3 |
| FDPS | JKAMP | 0.691446 | 3 | 0 | 3 |
| FDPS | IRF2BPL | 0.688193 | 3 | 0 | 3 |
| FDPS | ISCA2 | 0.686171 | 5 | 0 | 3 |
For details and further investigation, click here
