| Full name: DR1 associated protein 1 | Alias Symbol: NC2-alpha | ||
| Type: protein-coding gene | Cytoband: 11q13.1 | ||
| Entrez ID: 10589 | HGNC ID: HGNC:3019 | Ensembl Gene: ENSG00000175550 | OMIM ID: 602289 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of DRAP1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DRAP1 | 10589 | 203258_at | 0.3698 | 0.5034 | |
| GSE20347 | DRAP1 | 10589 | 203258_at | -0.0291 | 0.8842 | |
| GSE23400 | DRAP1 | 10589 | 203258_at | 0.0337 | 0.7334 | |
| GSE26886 | DRAP1 | 10589 | 203258_at | 0.4228 | 0.1567 | |
| GSE29001 | DRAP1 | 10589 | 203258_at | -0.0851 | 0.6950 | |
| GSE38129 | DRAP1 | 10589 | 203258_at | 0.1211 | 0.3965 | |
| GSE45670 | DRAP1 | 10589 | 203258_at | 0.0821 | 0.7423 | |
| GSE53622 | DRAP1 | 10589 | 7415 | -0.2032 | 0.0194 | |
| GSE53624 | DRAP1 | 10589 | 7415 | 0.0626 | 0.3002 | |
| GSE63941 | DRAP1 | 10589 | 203258_at | 1.7479 | 0.0004 | |
| GSE77861 | DRAP1 | 10589 | 203258_at | 0.2016 | 0.5094 | |
| GSE97050 | DRAP1 | 10589 | A_23_P138856 | 0.0762 | 0.7256 | |
| SRP007169 | DRAP1 | 10589 | RNAseq | -1.0505 | 0.0332 | |
| SRP008496 | DRAP1 | 10589 | RNAseq | -0.9634 | 0.0007 | |
| SRP064894 | DRAP1 | 10589 | RNAseq | 0.0928 | 0.7239 | |
| SRP133303 | DRAP1 | 10589 | RNAseq | 0.5718 | 0.0083 | |
| SRP159526 | DRAP1 | 10589 | RNAseq | 0.1627 | 0.4443 | |
| SRP193095 | DRAP1 | 10589 | RNAseq | 0.3280 | 0.1006 | |
| SRP219564 | DRAP1 | 10589 | RNAseq | 0.4058 | 0.3747 | |
| TCGA | DRAP1 | 10589 | RNAseq | 0.2781 | 0.0000 |
Upregulated datasets: 1; Downregulated datasets: 1.
Survival by DRAP1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DRAP1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DRAP1 | 10589 | 8 | 5 | 17 | |
| GSE20123 | DRAP1 | 10589 | 8 | 5 | 17 | |
| GSE43470 | DRAP1 | 10589 | 6 | 1 | 36 | |
| GSE46452 | DRAP1 | 10589 | 11 | 3 | 45 | |
| GSE47630 | DRAP1 | 10589 | 7 | 5 | 28 | |
| GSE54993 | DRAP1 | 10589 | 3 | 0 | 67 | |
| GSE54994 | DRAP1 | 10589 | 7 | 5 | 41 | |
| GSE60625 | DRAP1 | 10589 | 0 | 3 | 8 | |
| GSE74703 | DRAP1 | 10589 | 4 | 0 | 32 | |
| GSE74704 | DRAP1 | 10589 | 6 | 3 | 11 | |
| TCGA | DRAP1 | 10589 | 24 | 6 | 66 |
Total number of gains: 84; Total number of losses: 36; Total Number of normals: 368.
Somatic mutations of DRAP1:
Generating mutation plots.
Highly correlated genes for DRAP1:
Showing top 20/487 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DRAP1 | NUP35 | 0.790484 | 3 | 0 | 3 |
| DRAP1 | GPR153 | 0.78199 | 3 | 0 | 3 |
| DRAP1 | XRRA1 | 0.76814 | 3 | 0 | 3 |
| DRAP1 | ACTL6A | 0.757869 | 3 | 0 | 3 |
| DRAP1 | C3orf33 | 0.755094 | 3 | 0 | 3 |
| DRAP1 | MTCP1 | 0.752891 | 3 | 0 | 3 |
| DRAP1 | MRPL37 | 0.752227 | 3 | 0 | 3 |
| DRAP1 | TMEM41A | 0.749682 | 3 | 0 | 3 |
| DRAP1 | EIF2B5 | 0.741423 | 3 | 0 | 3 |
| DRAP1 | SHANK3 | 0.731508 | 3 | 0 | 3 |
| DRAP1 | MED9 | 0.730266 | 3 | 0 | 3 |
| DRAP1 | MYO9B | 0.72618 | 3 | 0 | 3 |
| DRAP1 | USP5 | 0.726047 | 4 | 0 | 4 |
| DRAP1 | ALG3 | 0.724505 | 4 | 0 | 4 |
| DRAP1 | BORA | 0.722824 | 3 | 0 | 3 |
| DRAP1 | ZNF354A | 0.722022 | 3 | 0 | 3 |
| DRAP1 | SASS6 | 0.712334 | 3 | 0 | 3 |
| DRAP1 | DPP9 | 0.712308 | 3 | 0 | 3 |
| DRAP1 | PIGX | 0.709081 | 3 | 0 | 3 |
| DRAP1 | UTP14A | 0.707456 | 3 | 0 | 3 |
For details and further investigation, click here
