| Full name: NPC intracellular cholesterol transporter 2 | Alias Symbol: HE1|NP-C2|EDDM1 | ||
| Type: protein-coding gene | Cytoband: 14q24.3 | ||
| Entrez ID: 10577 | HGNC ID: HGNC:14537 | Ensembl Gene: ENSG00000119655 | OMIM ID: 601015 |
| Drug and gene relationship at DGIdb | |||
Expression of NPC2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NPC2 | 10577 | 200701_at | 0.3288 | 0.4674 | |
| GSE20347 | NPC2 | 10577 | 200701_at | 0.0830 | 0.6785 | |
| GSE23400 | NPC2 | 10577 | 200701_at | 0.3311 | 0.0001 | |
| GSE26886 | NPC2 | 10577 | 200701_at | 0.3372 | 0.1374 | |
| GSE29001 | NPC2 | 10577 | 200701_at | 0.0931 | 0.7467 | |
| GSE38129 | NPC2 | 10577 | 200701_at | 0.3117 | 0.0885 | |
| GSE45670 | NPC2 | 10577 | 200701_at | 0.0195 | 0.9324 | |
| GSE53622 | NPC2 | 10577 | 101811 | 0.3860 | 0.0000 | |
| GSE53624 | NPC2 | 10577 | 101811 | 0.4797 | 0.0000 | |
| GSE63941 | NPC2 | 10577 | 200701_at | -0.6829 | 0.2770 | |
| GSE77861 | NPC2 | 10577 | 200701_at | -0.0585 | 0.9224 | |
| GSE97050 | NPC2 | 10577 | A_23_P48717 | 0.4142 | 0.3365 | |
| SRP007169 | NPC2 | 10577 | RNAseq | -0.1788 | 0.6477 | |
| SRP008496 | NPC2 | 10577 | RNAseq | -0.0879 | 0.7860 | |
| SRP064894 | NPC2 | 10577 | RNAseq | 0.7730 | 0.0141 | |
| SRP133303 | NPC2 | 10577 | RNAseq | 0.3623 | 0.0943 | |
| SRP159526 | NPC2 | 10577 | RNAseq | -0.2127 | 0.4116 | |
| SRP193095 | NPC2 | 10577 | RNAseq | -0.1859 | 0.2451 | |
| SRP219564 | NPC2 | 10577 | RNAseq | 0.7569 | 0.0026 | |
| TCGA | NPC2 | 10577 | RNAseq | 0.0573 | 0.2749 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by NPC2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NPC2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NPC2 | 10577 | 8 | 3 | 19 | |
| GSE20123 | NPC2 | 10577 | 8 | 3 | 19 | |
| GSE43470 | NPC2 | 10577 | 8 | 3 | 32 | |
| GSE46452 | NPC2 | 10577 | 16 | 3 | 40 | |
| GSE47630 | NPC2 | 10577 | 11 | 8 | 21 | |
| GSE54993 | NPC2 | 10577 | 3 | 8 | 59 | |
| GSE54994 | NPC2 | 10577 | 19 | 4 | 30 | |
| GSE60625 | NPC2 | 10577 | 0 | 2 | 9 | |
| GSE74703 | NPC2 | 10577 | 7 | 3 | 26 | |
| GSE74704 | NPC2 | 10577 | 3 | 3 | 14 | |
| TCGA | NPC2 | 10577 | 32 | 16 | 48 |
Total number of gains: 115; Total number of losses: 56; Total Number of normals: 317.
Somatic mutations of NPC2:
Generating mutation plots.
Highly correlated genes for NPC2:
Showing top 20/382 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NPC2 | DMAP1 | 0.718985 | 3 | 0 | 3 |
| NPC2 | FGF11 | 0.700218 | 3 | 0 | 3 |
| NPC2 | FDPS | 0.696473 | 3 | 0 | 3 |
| NPC2 | PITRM1 | 0.687528 | 3 | 0 | 3 |
| NPC2 | LIMK1 | 0.687233 | 4 | 0 | 4 |
| NPC2 | CEP128 | 0.681706 | 3 | 0 | 3 |
| NPC2 | LGALS8 | 0.677318 | 3 | 0 | 3 |
| NPC2 | SCAMP1 | 0.670527 | 3 | 0 | 3 |
| NPC2 | REST | 0.67016 | 3 | 0 | 3 |
| NPC2 | SPON2 | 0.669709 | 3 | 0 | 3 |
| NPC2 | GPAA1 | 0.667933 | 3 | 0 | 3 |
| NPC2 | LRIG2 | 0.667392 | 3 | 0 | 3 |
| NPC2 | KRTCAP2 | 0.666333 | 4 | 0 | 3 |
| NPC2 | DNAJC3 | 0.660429 | 3 | 0 | 3 |
| NPC2 | BTF3 | 0.655212 | 3 | 0 | 3 |
| NPC2 | GAPDH | 0.654386 | 4 | 0 | 3 |
| NPC2 | OSR2 | 0.654059 | 4 | 0 | 3 |
| NPC2 | LRRC8C | 0.651984 | 3 | 0 | 3 |
| NPC2 | IMPDH2 | 0.651672 | 3 | 0 | 3 |
| NPC2 | LSR | 0.650645 | 4 | 0 | 3 |
For details and further investigation, click here
