| Full name: gamma-glutamyltransferase 5 | Alias Symbol: GGT-REL | ||
| Type: protein-coding gene | Cytoband: 22q11.23 | ||
| Entrez ID: 2687 | HGNC ID: HGNC:4260 | Ensembl Gene: ENSG00000099998 | OMIM ID: 137168 |
| Drug and gene relationship at DGIdb | |||
Expression of GGT5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GGT5 | 2687 | 205582_s_at | 0.1225 | 0.8123 | |
| GSE20347 | GGT5 | 2687 | 205582_s_at | 0.1441 | 0.0456 | |
| GSE23400 | GGT5 | 2687 | 205582_s_at | 0.0924 | 0.0673 | |
| GSE26886 | GGT5 | 2687 | 205582_s_at | 0.5910 | 0.0016 | |
| GSE29001 | GGT5 | 2687 | 205582_s_at | 0.0899 | 0.6001 | |
| GSE38129 | GGT5 | 2687 | 205582_s_at | -0.0171 | 0.9435 | |
| GSE45670 | GGT5 | 2687 | 205582_s_at | 0.0289 | 0.8262 | |
| GSE53622 | GGT5 | 2687 | 107184 | 0.3941 | 0.0014 | |
| GSE53624 | GGT5 | 2687 | 107184 | 0.6999 | 0.0000 | |
| GSE63941 | GGT5 | 2687 | 205582_s_at | -0.0976 | 0.7398 | |
| GSE77861 | GGT5 | 2687 | 205582_s_at | -0.0787 | 0.5693 | |
| GSE97050 | GGT5 | 2687 | A_33_P3255304 | 0.8045 | 0.1889 | |
| SRP007169 | GGT5 | 2687 | RNAseq | 2.3014 | 0.0027 | |
| SRP064894 | GGT5 | 2687 | RNAseq | 1.2320 | 0.0000 | |
| SRP133303 | GGT5 | 2687 | RNAseq | 0.6443 | 0.0233 | |
| SRP159526 | GGT5 | 2687 | RNAseq | 0.2485 | 0.4665 | |
| SRP193095 | GGT5 | 2687 | RNAseq | 1.7754 | 0.0000 | |
| SRP219564 | GGT5 | 2687 | RNAseq | 0.6072 | 0.2743 | |
| TCGA | GGT5 | 2687 | RNAseq | -0.0407 | 0.7289 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by GGT5 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GGT5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GGT5 | 2687 | 5 | 7 | 18 | |
| GSE20123 | GGT5 | 2687 | 5 | 6 | 19 | |
| GSE43470 | GGT5 | 2687 | 3 | 6 | 34 | |
| GSE46452 | GGT5 | 2687 | 32 | 1 | 26 | |
| GSE47630 | GGT5 | 2687 | 8 | 5 | 27 | |
| GSE54993 | GGT5 | 2687 | 3 | 6 | 61 | |
| GSE54994 | GGT5 | 2687 | 11 | 7 | 35 | |
| GSE60625 | GGT5 | 2687 | 5 | 0 | 6 | |
| GSE74703 | GGT5 | 2687 | 3 | 5 | 28 | |
| GSE74704 | GGT5 | 2687 | 2 | 3 | 15 | |
| TCGA | GGT5 | 2687 | 26 | 15 | 55 |
Total number of gains: 103; Total number of losses: 61; Total Number of normals: 324.
Somatic mutations of GGT5:
Generating mutation plots.
Highly correlated genes for GGT5:
Showing top 20/920 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GGT5 | HAGHL | 0.787677 | 3 | 0 | 3 |
| GGT5 | ZNF628 | 0.750335 | 3 | 0 | 3 |
| GGT5 | RBP5 | 0.739976 | 3 | 0 | 3 |
| GGT5 | DOC2B | 0.734221 | 5 | 0 | 5 |
| GGT5 | SMARCD1 | 0.733064 | 3 | 0 | 3 |
| GGT5 | PDCD1LG2 | 0.729729 | 5 | 0 | 5 |
| GGT5 | SLFN11 | 0.729086 | 4 | 0 | 4 |
| GGT5 | CCDC102B | 0.725852 | 3 | 0 | 3 |
| GGT5 | MAPK8IP3 | 0.725325 | 3 | 0 | 3 |
| GGT5 | ACY1 | 0.713905 | 3 | 0 | 3 |
| GGT5 | SSTR3 | 0.70891 | 3 | 0 | 3 |
| GGT5 | PROX1 | 0.707109 | 3 | 0 | 3 |
| GGT5 | ADAM15 | 0.705063 | 3 | 0 | 3 |
| GGT5 | RNASE3 | 0.704733 | 3 | 0 | 3 |
| GGT5 | CLSTN2 | 0.703813 | 4 | 0 | 4 |
| GGT5 | PCGF1 | 0.703185 | 3 | 0 | 3 |
| GGT5 | LRRC55 | 0.702995 | 3 | 0 | 3 |
| GGT5 | FRMD5 | 0.702589 | 4 | 0 | 3 |
| GGT5 | PLIN4 | 0.702537 | 3 | 0 | 3 |
| GGT5 | CNTROB | 0.702095 | 3 | 0 | 3 |
For details and further investigation, click here
