| Full name: tolloid like 1 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 4q32.3 | ||
| Entrez ID: 7092 | HGNC ID: HGNC:11843 | Ensembl Gene: ENSG00000038295 | OMIM ID: 606742 |
| Drug and gene relationship at DGIdb | |||
Expression of TLL1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TLL1 | 7092 | 1555071_at | -0.0449 | 0.8797 | |
| GSE20347 | TLL1 | 7092 | 206415_at | -0.0228 | 0.6616 | |
| GSE23400 | TLL1 | 7092 | 206415_at | -0.0161 | 0.3957 | |
| GSE26886 | TLL1 | 7092 | 1555071_at | 0.1827 | 0.4120 | |
| GSE29001 | TLL1 | 7092 | 206415_at | 0.2316 | 0.2432 | |
| GSE38129 | TLL1 | 7092 | 206415_at | -0.0598 | 0.2422 | |
| GSE45670 | TLL1 | 7092 | 206415_at | 0.0737 | 0.7535 | |
| GSE53622 | TLL1 | 7092 | 19872 | -1.2474 | 0.0000 | |
| GSE53624 | TLL1 | 7092 | 19872 | -0.6131 | 0.0058 | |
| GSE63941 | TLL1 | 7092 | 1555071_at | -0.0731 | 0.7573 | |
| GSE77861 | TLL1 | 7092 | 1555071_at | 0.0223 | 0.8254 | |
| GSE97050 | TLL1 | A_21_P0000156 | -0.0186 | 0.9362 | ||
| SRP007169 | TLL1 | 7092 | RNAseq | -0.0193 | 0.9806 | |
| SRP064894 | TLL1 | 7092 | RNAseq | 1.4608 | 0.0003 | |
| SRP133303 | TLL1 | 7092 | RNAseq | -0.2025 | 0.6953 | |
| SRP159526 | TLL1 | 7092 | RNAseq | -0.1838 | 0.7580 | |
| SRP193095 | TLL1 | 7092 | RNAseq | 1.0450 | 0.0115 | |
| SRP219564 | TLL1 | 7092 | RNAseq | 1.5455 | 0.0213 | |
| TCGA | TLL1 | 7092 | RNAseq | -0.2885 | 0.3838 |
Upregulated datasets: 3; Downregulated datasets: 1.
Survival by TLL1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TLL1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TLL1 | 7092 | 0 | 11 | 19 | |
| GSE20123 | TLL1 | 7092 | 0 | 11 | 19 | |
| GSE43470 | TLL1 | 7092 | 0 | 13 | 30 | |
| GSE46452 | TLL1 | 7092 | 1 | 36 | 22 | |
| GSE47630 | TLL1 | 7092 | 0 | 22 | 18 | |
| GSE54993 | TLL1 | 7092 | 10 | 0 | 60 | |
| GSE54994 | TLL1 | 7092 | 1 | 13 | 39 | |
| GSE60625 | TLL1 | 7092 | 0 | 0 | 11 | |
| GSE74703 | TLL1 | 7092 | 0 | 11 | 25 | |
| GSE74704 | TLL1 | 7092 | 0 | 5 | 15 | |
| TCGA | TLL1 | 7092 | 11 | 33 | 52 |
Total number of gains: 23; Total number of losses: 155; Total Number of normals: 310.
Somatic mutations of TLL1:
Generating mutation plots.
Highly correlated genes for TLL1:
Showing top 20/255 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TLL1 | NPY1R | 0.677599 | 3 | 0 | 3 |
| TLL1 | FGB | 0.672808 | 3 | 0 | 3 |
| TLL1 | IL5RA | 0.670639 | 3 | 0 | 3 |
| TLL1 | SLC11A1 | 0.655167 | 3 | 0 | 3 |
| TLL1 | HAO1 | 0.653737 | 3 | 0 | 3 |
| TLL1 | OR7E24 | 0.641341 | 3 | 0 | 3 |
| TLL1 | MMRN2 | 0.624493 | 5 | 0 | 5 |
| TLL1 | TGFBR2 | 0.620778 | 5 | 0 | 5 |
| TLL1 | SERPIND1 | 0.615281 | 3 | 0 | 3 |
| TLL1 | LRCH2 | 0.61484 | 5 | 0 | 4 |
| TLL1 | ADAMTS2 | 0.611453 | 3 | 0 | 3 |
| TLL1 | RHOJ | 0.607365 | 5 | 0 | 4 |
| TLL1 | CHRM2 | 0.604259 | 4 | 0 | 3 |
| TLL1 | GNG11 | 0.604222 | 6 | 0 | 5 |
| TLL1 | ANK2 | 0.60336 | 4 | 0 | 4 |
| TLL1 | FRY | 0.60284 | 3 | 0 | 3 |
| TLL1 | TIE1 | 0.601773 | 5 | 0 | 5 |
| TLL1 | DCHS1 | 0.601059 | 3 | 0 | 3 |
| TLL1 | HAND2 | 0.601028 | 4 | 0 | 3 |
| TLL1 | NMBR | 0.600715 | 4 | 0 | 3 |
For details and further investigation, click here
