| Full name: fibroblast growth factor 19 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 11q13.3 | ||
| Entrez ID: 9965 | HGNC ID: HGNC:3675 | Ensembl Gene: ENSG00000162344 | OMIM ID: 603891 |
| Drug and gene relationship at DGIdb | |||
FGF19 involved pathways:
Expression of FGF19:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | FGF19 | 9965 | 223761_at | 0.8767 | 0.3586 | |
| GSE26886 | FGF19 | 9965 | 223761_at | 0.5367 | 0.1212 | |
| GSE45670 | FGF19 | 9965 | 223761_at | 0.3653 | 0.0898 | |
| GSE53622 | FGF19 | 9965 | 59347 | 1.6439 | 0.0000 | |
| GSE53624 | FGF19 | 9965 | 59347 | 2.0095 | 0.0000 | |
| GSE63941 | FGF19 | 9965 | 223761_at | 1.5842 | 0.3598 | |
| GSE77861 | FGF19 | 9965 | 223761_at | 0.6329 | 0.3547 | |
| SRP159526 | FGF19 | 9965 | RNAseq | 8.7639 | 0.0000 | |
| TCGA | FGF19 | 9965 | RNAseq | 3.1942 | 0.0000 |
Upregulated datasets: 4; Downregulated datasets: 0.
Survival by FGF19 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of FGF19:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | FGF19 | 9965 | 20 | 1 | 9 | |
| GSE20123 | FGF19 | 9965 | 20 | 1 | 9 | |
| GSE43470 | FGF19 | 9965 | 16 | 2 | 25 | |
| GSE46452 | FGF19 | 9965 | 37 | 0 | 22 | |
| GSE47630 | FGF19 | 9965 | 20 | 1 | 19 | |
| GSE54993 | FGF19 | 9965 | 1 | 25 | 44 | |
| GSE54994 | FGF19 | 9965 | 27 | 3 | 23 | |
| GSE60625 | FGF19 | 9965 | 0 | 4 | 7 | |
| GSE74703 | FGF19 | 9965 | 13 | 1 | 22 | |
| GSE74704 | FGF19 | 9965 | 13 | 0 | 7 | |
| TCGA | FGF19 | 9965 | 62 | 3 | 31 |
Total number of gains: 229; Total number of losses: 41; Total Number of normals: 218.
Somatic mutations of FGF19:
Generating mutation plots.
Highly correlated genes for FGF19:
Showing top 20/52 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| FGF19 | CASC15 | 0.721196 | 4 | 0 | 3 |
| FGF19 | KCNQ5 | 0.708301 | 3 | 0 | 3 |
| FGF19 | CLDN20 | 0.682127 | 4 | 0 | 3 |
| FGF19 | KRTAP19-1 | 0.66535 | 3 | 0 | 3 |
| FGF19 | C6orf15 | 0.655865 | 4 | 0 | 3 |
| FGF19 | SOST | 0.655475 | 5 | 0 | 3 |
| FGF19 | AK8 | 0.653004 | 3 | 0 | 3 |
| FGF19 | MSI1 | 0.645331 | 3 | 0 | 3 |
| FGF19 | HAS2 | 0.617043 | 4 | 0 | 3 |
| FGF19 | PRAME | 0.614688 | 4 | 0 | 4 |
| FGF19 | SCN9A | 0.609835 | 5 | 0 | 3 |
| FGF19 | MPPED1 | 0.604934 | 5 | 0 | 4 |
| FGF19 | DLGAP1-AS2 | 0.60115 | 6 | 0 | 4 |
| FGF19 | POMC | 0.600258 | 5 | 0 | 3 |
| FGF19 | DLGAP1-AS1 | 0.59722 | 4 | 0 | 3 |
| FGF19 | LGR6 | 0.595802 | 5 | 0 | 3 |
| FGF19 | SLC39A10 | 0.588016 | 4 | 0 | 3 |
| FGF19 | DLX6-AS1 | 0.582326 | 4 | 0 | 3 |
| FGF19 | SOX11 | 0.582248 | 4 | 0 | 4 |
| FGF19 | SPRY4 | 0.581553 | 5 | 0 | 4 |
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