FGF19

 

Full name: fibroblast growth factor 19 Alias Symbol: 
Type: protein-coding gene Cytoband: 11q13.3
Entrez ID: 9965 HGNC ID: HGNC:3675 Ensembl Gene: ENSG00000162344 OMIM ID: 603891
Drug and gene relationship at DGIdb

 

FGF19 involved pathways:

KEGG pathway Description View
hsa04010MAPK signaling pathway
hsa04014Ras signaling pathway
hsa04015Rap1 signaling pathway
hsa04151PI3K-Akt signaling pathway
hsa05200Pathways in cancer
hsa05218Melanoma

 

Expression of FGF19:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 FGF19 9965 223761_at 0.8767 0.3586
GSE26886 FGF19 9965 223761_at 0.5367 0.1212
GSE45670 FGF19 9965 223761_at 0.3653 0.0898
GSE53622 FGF19 9965 59347 1.6439 0.0000
GSE53624 FGF19 9965 59347 2.0095 0.0000
GSE63941 FGF19 9965 223761_at 1.5842 0.3598
GSE77861 FGF19 9965 223761_at 0.6329 0.3547
SRP159526 FGF19 9965 RNAseq 8.7639 0.0000
TCGA FGF19 9965 RNAseq 3.1942 0.0000

Upregulated datasets: 4; Downregulated datasets: 0.  


 

Survival by FGF19 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  


Copy number change of FGF19:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 FGF19 9965 20 1 9
GSE20123 FGF19 9965 20 1 9
GSE43470 FGF19 9965 16 2 25
GSE46452 FGF19 9965 37 0 22
GSE47630 FGF19 9965 20 1 19
GSE54993 FGF19 9965 1 25 44
GSE54994 FGF19 9965 27 3 23
GSE60625 FGF19 9965 0 4 7
GSE74703 FGF19 9965 13 1 22
GSE74704 FGF19 9965 13 0 7
TCGA FGF19 9965 62 3 31

Total number of gains: 229; Total number of losses: 41; Total Number of normals: 218.  


 

Somatic mutations of FGF19:

 

Generating mutation plots.

 

Highly correlated genes for FGF19:

 

Showing top 20/52 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
FGF19CASC150.721196403
FGF19KCNQ50.708301303
FGF19CLDN200.682127403
FGF19KRTAP19-10.66535303
FGF19C6orf150.655865403
FGF19SOST0.655475503
FGF19AK80.653004303
FGF19MSI10.645331303
FGF19HAS20.617043403
FGF19PRAME0.614688404
FGF19SCN9A0.609835503
FGF19MPPED10.604934504
FGF19DLGAP1-AS20.60115604
FGF19POMC0.600258503
FGF19DLGAP1-AS10.59722403
FGF19LGR60.595802503
FGF19SLC39A100.588016403
FGF19DLX6-AS10.582326403
FGF19SOX110.582248404
FGF19SPRY40.581553504

For details and further investigation, click here