| Full name: SRY-box transcription factor 11 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 2p25.2 | ||
| Entrez ID: 6664 | HGNC ID: HGNC:11191 | Ensembl Gene: ENSG00000176887 | OMIM ID: 600898 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of SOX11:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SOX11 | 6664 | 204915_s_at | 0.3661 | 0.3399 | |
| GSE20347 | SOX11 | 6664 | 204914_s_at | 0.8830 | 0.0008 | |
| GSE23400 | SOX11 | 6664 | 204914_s_at | 0.0928 | 0.0106 | |
| GSE26886 | SOX11 | 6664 | 204914_s_at | 0.2648 | 0.1840 | |
| GSE29001 | SOX11 | 6664 | 204915_s_at | 0.4381 | 0.0169 | |
| GSE38129 | SOX11 | 6664 | 204915_s_at | 0.2362 | 0.0594 | |
| GSE45670 | SOX11 | 6664 | 204915_s_at | 0.2400 | 0.0930 | |
| GSE53622 | SOX11 | 6664 | 19860 | 1.9150 | 0.0000 | |
| GSE53624 | SOX11 | 6664 | 19860 | 1.8111 | 0.0000 | |
| GSE63941 | SOX11 | 6664 | 204914_s_at | 0.4595 | 0.6874 | |
| GSE77861 | SOX11 | 6664 | 204914_s_at | 0.0981 | 0.7185 | |
| SRP133303 | SOX11 | 6664 | RNAseq | 2.7933 | 0.0000 | |
| SRP219564 | SOX11 | 6664 | RNAseq | 2.2119 | 0.0043 | |
| TCGA | SOX11 | 6664 | RNAseq | 1.5553 | 0.0000 |
Upregulated datasets: 5; Downregulated datasets: 0.
Survival by SOX11 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SOX11:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SOX11 | 6664 | 8 | 1 | 21 | |
| GSE20123 | SOX11 | 6664 | 8 | 1 | 21 | |
| GSE43470 | SOX11 | 6664 | 2 | 0 | 41 | |
| GSE46452 | SOX11 | 6664 | 3 | 4 | 52 | |
| GSE47630 | SOX11 | 6664 | 7 | 0 | 33 | |
| GSE54993 | SOX11 | 6664 | 0 | 7 | 63 | |
| GSE54994 | SOX11 | 6664 | 11 | 0 | 42 | |
| GSE60625 | SOX11 | 6664 | 0 | 3 | 8 | |
| GSE74703 | SOX11 | 6664 | 2 | 0 | 34 | |
| GSE74704 | SOX11 | 6664 | 8 | 1 | 11 | |
| TCGA | SOX11 | 6664 | 33 | 5 | 58 |
Total number of gains: 82; Total number of losses: 22; Total Number of normals: 384.
Somatic mutations of SOX11:
Generating mutation plots.
Highly correlated genes for SOX11:
Showing top 20/520 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SOX11 | C1QTNF6 | 0.70093 | 3 | 0 | 3 |
| SOX11 | MPLKIP | 0.69895 | 3 | 0 | 3 |
| SOX11 | ST20 | 0.694041 | 4 | 0 | 4 |
| SOX11 | GPR161 | 0.667287 | 3 | 0 | 3 |
| SOX11 | LHX2 | 0.667211 | 3 | 0 | 3 |
| SOX11 | KIF14 | 0.663756 | 5 | 0 | 5 |
| SOX11 | GPRIN1 | 0.661144 | 4 | 0 | 4 |
| SOX11 | IRF2BPL | 0.657778 | 4 | 0 | 4 |
| SOX11 | PDE7A | 0.64831 | 3 | 0 | 3 |
| SOX11 | KNSTRN | 0.644324 | 4 | 0 | 3 |
| SOX11 | NOP58 | 0.643333 | 3 | 0 | 3 |
| SOX11 | DDHD1 | 0.64189 | 3 | 0 | 3 |
| SOX11 | COL27A1 | 0.639955 | 3 | 0 | 3 |
| SOX11 | PPP4R4 | 0.636229 | 3 | 0 | 3 |
| SOX11 | COL12A1 | 0.633133 | 3 | 0 | 3 |
| SOX11 | NUF2 | 0.631531 | 3 | 0 | 3 |
| SOX11 | FMNL2 | 0.630381 | 4 | 0 | 3 |
| SOX11 | ASPM | 0.629164 | 4 | 0 | 3 |
| SOX11 | DPY19L1 | 0.628281 | 6 | 0 | 4 |
| SOX11 | DNMT1 | 0.626059 | 5 | 0 | 4 |
For details and further investigation, click here
