| Full name: sodium voltage-gated channel alpha subunit 9 | Alias Symbol: Nav1.7|PN1|NE-NA|NENA|ETHA | ||
| Type: protein-coding gene | Cytoband: 2q24.3 | ||
| Entrez ID: 6335 | HGNC ID: HGNC:10597 | Ensembl Gene: ENSG00000169432 | OMIM ID: 603415 |
| Drug and gene relationship at DGIdb | |||
SCN9A involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04742 | Taste transduction |
Expression of SCN9A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SCN9A | 6335 | 206950_at | 0.7544 | 0.5182 | |
| GSE20347 | SCN9A | 6335 | 206950_at | 0.8949 | 0.0097 | |
| GSE23400 | SCN9A | 6335 | 206950_at | 0.2289 | 0.0061 | |
| GSE26886 | SCN9A | 6335 | 206950_at | 2.2763 | 0.0015 | |
| GSE29001 | SCN9A | 6335 | 206950_at | 1.0828 | 0.0657 | |
| GSE38129 | SCN9A | 6335 | 206950_at | 1.1491 | 0.0003 | |
| GSE45670 | SCN9A | 6335 | 206950_at | 0.9037 | 0.3071 | |
| GSE53622 | SCN9A | 6335 | 65274 | 0.4647 | 0.0000 | |
| GSE53624 | SCN9A | 6335 | 65274 | 0.7743 | 0.0000 | |
| GSE63941 | SCN9A | 6335 | 206950_at | -4.2208 | 0.0005 | |
| GSE77861 | SCN9A | 6335 | 229199_at | 0.4771 | 0.0428 | |
| GSE97050 | SCN9A | 6335 | A_24_P3005 | 0.1793 | 0.5488 | |
| SRP007169 | SCN9A | 6335 | RNAseq | 6.3732 | 0.0000 | |
| SRP064894 | SCN9A | 6335 | RNAseq | 2.0686 | 0.0000 | |
| SRP133303 | SCN9A | 6335 | RNAseq | 1.0589 | 0.0262 | |
| SRP159526 | SCN9A | 6335 | RNAseq | 4.2953 | 0.0000 | |
| SRP193095 | SCN9A | 6335 | RNAseq | 2.9584 | 0.0000 | |
| SRP219564 | SCN9A | 6335 | RNAseq | 1.2237 | 0.1236 | |
| TCGA | SCN9A | 6335 | RNAseq | 0.1633 | 0.6568 |
Upregulated datasets: 7; Downregulated datasets: 1.
Survival by SCN9A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SCN9A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SCN9A | 6335 | 5 | 1 | 24 | |
| GSE20123 | SCN9A | 6335 | 4 | 1 | 25 | |
| GSE43470 | SCN9A | 6335 | 5 | 1 | 37 | |
| GSE46452 | SCN9A | 6335 | 1 | 4 | 54 | |
| GSE47630 | SCN9A | 6335 | 5 | 3 | 32 | |
| GSE54993 | SCN9A | 6335 | 0 | 5 | 65 | |
| GSE54994 | SCN9A | 6335 | 11 | 2 | 40 | |
| GSE60625 | SCN9A | 6335 | 0 | 3 | 8 | |
| GSE74703 | SCN9A | 6335 | 4 | 1 | 31 | |
| GSE74704 | SCN9A | 6335 | 2 | 0 | 18 | |
| TCGA | SCN9A | 6335 | 24 | 9 | 63 |
Total number of gains: 61; Total number of losses: 30; Total Number of normals: 397.
Somatic mutations of SCN9A:
Generating mutation plots.
Highly correlated genes for SCN9A:
Showing top 20/186 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SCN9A | CRYGA | 0.766809 | 3 | 0 | 3 |
| SCN9A | SCARF2 | 0.740239 | 3 | 0 | 3 |
| SCN9A | LYPD6 | 0.738182 | 3 | 0 | 3 |
| SCN9A | SORCS2 | 0.737807 | 3 | 0 | 3 |
| SCN9A | CDC42EP2 | 0.733989 | 3 | 0 | 3 |
| SCN9A | EMILIN1 | 0.730613 | 3 | 0 | 3 |
| SCN9A | FOXL2 | 0.720735 | 5 | 0 | 5 |
| SCN9A | TCTE3 | 0.719697 | 3 | 0 | 3 |
| SCN9A | SCN3A | 0.71186 | 4 | 0 | 3 |
| SCN9A | KLHL26 | 0.706905 | 3 | 0 | 3 |
| SCN9A | TFE3 | 0.702807 | 6 | 0 | 5 |
| SCN9A | ISL2 | 0.697204 | 3 | 0 | 3 |
| SCN9A | PRKAG3 | 0.696806 | 3 | 0 | 3 |
| SCN9A | DNAL4 | 0.695481 | 3 | 0 | 3 |
| SCN9A | DNLZ | 0.693155 | 3 | 0 | 3 |
| SCN9A | PRSS35 | 0.692564 | 3 | 0 | 3 |
| SCN9A | OSGIN1 | 0.689983 | 9 | 0 | 9 |
| SCN9A | SLC35G1 | 0.682875 | 6 | 0 | 5 |
| SCN9A | AGRP | 0.677467 | 3 | 0 | 3 |
| SCN9A | PGP | 0.674605 | 5 | 0 | 5 |
For details and further investigation, click here
