| Full name: claudin 20 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 6q25.3 | ||
| Entrez ID: 49861 | HGNC ID: HGNC:2042 | Ensembl Gene: ENSG00000171217 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
CLDN20 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04530 | Tight junction |
Expression of CLDN20:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CLDN20 | 49861 | 1554812_at | 0.2926 | 0.6662 | |
| GSE26886 | CLDN20 | 49861 | 1554812_at | 1.0465 | 0.1205 | |
| GSE45670 | CLDN20 | 49861 | 1554812_at | 0.5196 | 0.3588 | |
| GSE53622 | CLDN20 | 49861 | 14531 | 0.7021 | 0.0016 | |
| GSE53624 | CLDN20 | 49861 | 14531 | 1.2917 | 0.0000 | |
| GSE63941 | CLDN20 | 49861 | 1554812_at | 0.2225 | 0.7557 | |
| GSE77861 | CLDN20 | 49861 | 1554812_at | 0.3234 | 0.0846 | |
| SRP007169 | CLDN20 | 49861 | RNAseq | 3.8111 | 0.0009 | |
| SRP133303 | CLDN20 | 49861 | RNAseq | 0.4180 | 0.0588 | |
| SRP159526 | CLDN20 | 49861 | RNAseq | 2.0467 | 0.0013 | |
| SRP193095 | CLDN20 | 49861 | RNAseq | 0.5675 | 0.0030 | |
| TCGA | CLDN20 | 49861 | RNAseq | 0.8915 | 0.0477 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by CLDN20 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CLDN20:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CLDN20 | 49861 | 1 | 4 | 25 | |
| GSE20123 | CLDN20 | 49861 | 1 | 3 | 26 | |
| GSE43470 | CLDN20 | 49861 | 4 | 0 | 39 | |
| GSE46452 | CLDN20 | 49861 | 3 | 10 | 46 | |
| GSE47630 | CLDN20 | 49861 | 9 | 4 | 27 | |
| GSE54993 | CLDN20 | 49861 | 3 | 2 | 65 | |
| GSE54994 | CLDN20 | 49861 | 8 | 8 | 37 | |
| GSE60625 | CLDN20 | 49861 | 0 | 1 | 10 | |
| GSE74703 | CLDN20 | 49861 | 4 | 0 | 32 | |
| GSE74704 | CLDN20 | 49861 | 0 | 1 | 19 | |
| TCGA | CLDN20 | 49861 | 12 | 21 | 63 |
Total number of gains: 45; Total number of losses: 54; Total Number of normals: 389.
Somatic mutations of CLDN20:
Generating mutation plots.
Highly correlated genes for CLDN20:
Showing top 20/73 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CLDN20 | STK32B | 0.741762 | 3 | 0 | 3 |
| CLDN20 | SETX | 0.718215 | 3 | 0 | 3 |
| CLDN20 | SOST | 0.706687 | 4 | 0 | 3 |
| CLDN20 | SOX5 | 0.703774 | 3 | 0 | 3 |
| CLDN20 | FGF19 | 0.682127 | 4 | 0 | 3 |
| CLDN20 | FREM2 | 0.676023 | 5 | 0 | 5 |
| CLDN20 | KRTAP19-1 | 0.675108 | 4 | 0 | 4 |
| CLDN20 | JAKMIP3 | 0.673274 | 4 | 0 | 3 |
| CLDN20 | TMEM116 | 0.650709 | 6 | 0 | 4 |
| CLDN20 | STAG2 | 0.644275 | 3 | 0 | 3 |
| CLDN20 | SOX2-OT | 0.637615 | 7 | 0 | 6 |
| CLDN20 | NDUFAF4 | 0.634521 | 3 | 0 | 3 |
| CLDN20 | PSMB3 | 0.630737 | 3 | 0 | 3 |
| CLDN20 | CASC15 | 0.63051 | 4 | 0 | 3 |
| CLDN20 | CYP4F11 | 0.624638 | 5 | 0 | 3 |
| CLDN20 | LINC01206 | 0.620971 | 4 | 0 | 3 |
| CLDN20 | GABRG3 | 0.619923 | 5 | 0 | 3 |
| CLDN20 | VMA21 | 0.615893 | 3 | 0 | 3 |
| CLDN20 | NXPE3 | 0.614482 | 3 | 0 | 3 |
| CLDN20 | QRFPR | 0.613727 | 5 | 0 | 4 |
For details and further investigation, click here
