| Full name: proopiomelanocortin | Alias Symbol: MSH|POC|CLIP|ACTH|NPP|LPH | ||
| Type: protein-coding gene | Cytoband: 2p23.3 | ||
| Entrez ID: 5443 | HGNC ID: HGNC:9201 | Ensembl Gene: ENSG00000115138 | OMIM ID: 176830 |
| Drug and gene relationship at DGIdb | |||
POMC involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04916 | Melanogenesis | |
| hsa04920 | Adipocytokine signaling pathway |
Expression of POMC:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | POMC | 5443 | 205720_at | -0.0182 | 0.9698 | |
| GSE20347 | POMC | 5443 | 205720_at | 0.1409 | 0.2601 | |
| GSE23400 | POMC | 5443 | 205720_at | -0.0849 | 0.0448 | |
| GSE26886 | POMC | 5443 | 205720_at | 0.5493 | 0.0050 | |
| GSE29001 | POMC | 5443 | 205720_at | -0.0617 | 0.6064 | |
| GSE38129 | POMC | 5443 | 205720_at | 0.2284 | 0.2445 | |
| GSE45670 | POMC | 5443 | 205720_at | 0.0152 | 0.9242 | |
| GSE53622 | POMC | 5443 | 62178 | 0.5943 | 0.0001 | |
| GSE53624 | POMC | 5443 | 62178 | 0.8244 | 0.0000 | |
| GSE63941 | POMC | 5443 | 205720_at | 0.3584 | 0.0386 | |
| GSE77861 | POMC | 5443 | 205720_at | 0.1642 | 0.4665 | |
| GSE97050 | POMC | 5443 | A_33_P3345036 | 0.0334 | 0.9041 | |
| SRP159526 | POMC | 5443 | RNAseq | 4.9290 | 0.0000 | |
| SRP219564 | POMC | 5443 | RNAseq | -0.8672 | 0.3136 | |
| TCGA | POMC | 5443 | RNAseq | 1.5203 | 0.0005 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by POMC expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of POMC:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | POMC | 5443 | 11 | 2 | 17 | |
| GSE20123 | POMC | 5443 | 11 | 2 | 17 | |
| GSE43470 | POMC | 5443 | 3 | 1 | 39 | |
| GSE46452 | POMC | 5443 | 3 | 4 | 52 | |
| GSE47630 | POMC | 5443 | 8 | 0 | 32 | |
| GSE54993 | POMC | 5443 | 0 | 6 | 64 | |
| GSE54994 | POMC | 5443 | 10 | 0 | 43 | |
| GSE60625 | POMC | 5443 | 0 | 3 | 8 | |
| GSE74703 | POMC | 5443 | 3 | 0 | 33 | |
| GSE74704 | POMC | 5443 | 9 | 1 | 10 | |
| TCGA | POMC | 5443 | 37 | 2 | 57 |
Total number of gains: 95; Total number of losses: 21; Total Number of normals: 372.
Somatic mutations of POMC:
Generating mutation plots.
Highly correlated genes for POMC:
Showing top 20/194 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| POMC | SCGN | 0.715372 | 3 | 0 | 3 |
| POMC | MIIP | 0.712785 | 3 | 0 | 3 |
| POMC | NPBWR1 | 0.703778 | 3 | 0 | 3 |
| POMC | POLD1 | 0.702807 | 3 | 0 | 3 |
| POMC | GDF2 | 0.696548 | 3 | 0 | 3 |
| POMC | IGSF9B | 0.686045 | 3 | 0 | 3 |
| POMC | SLC6A3 | 0.674518 | 5 | 0 | 5 |
| POMC | ADCY1 | 0.670077 | 4 | 0 | 4 |
| POMC | TLR9 | 0.669174 | 3 | 0 | 3 |
| POMC | LRFN1 | 0.666188 | 4 | 0 | 4 |
| POMC | RASL10B | 0.663517 | 4 | 0 | 3 |
| POMC | UFSP1 | 0.64803 | 4 | 0 | 3 |
| POMC | CA6 | 0.646393 | 5 | 0 | 3 |
| POMC | PLA2G4F | 0.643916 | 3 | 0 | 3 |
| POMC | NPM3 | 0.643516 | 3 | 0 | 3 |
| POMC | NPW | 0.640686 | 3 | 0 | 3 |
| POMC | GBX2 | 0.638845 | 4 | 0 | 4 |
| POMC | SLC22A11 | 0.635988 | 3 | 0 | 3 |
| POMC | TM6SF2 | 0.635064 | 4 | 0 | 3 |
| POMC | PPIP5K1 | 0.634194 | 3 | 0 | 3 |
For details and further investigation, click here
