| Full name: sprouty RTK signaling antagonist 4 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 5q31.3 | ||
| Entrez ID: 81848 | HGNC ID: HGNC:15533 | Ensembl Gene: ENSG00000187678 | OMIM ID: 607984 |
| Drug and gene relationship at DGIdb | |||
Expression of SPRY4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SPRY4 | 81848 | 221489_s_at | 0.4804 | 0.5056 | |
| GSE20347 | SPRY4 | 81848 | 221489_s_at | 0.7019 | 0.0032 | |
| GSE23400 | SPRY4 | 81848 | 221489_s_at | 0.2993 | 0.0000 | |
| GSE26886 | SPRY4 | 81848 | 221489_s_at | 0.6734 | 0.0148 | |
| GSE29001 | SPRY4 | 81848 | 221489_s_at | 0.4732 | 0.0785 | |
| GSE38129 | SPRY4 | 81848 | 221489_s_at | 0.5914 | 0.0125 | |
| GSE45670 | SPRY4 | 81848 | 221489_s_at | 0.5521 | 0.0107 | |
| GSE53622 | SPRY4 | 81848 | 14374 | 1.2119 | 0.0000 | |
| GSE53624 | SPRY4 | 81848 | 14374 | 0.9273 | 0.0000 | |
| GSE63941 | SPRY4 | 81848 | 221489_s_at | -1.1461 | 0.0643 | |
| GSE77861 | SPRY4 | 81848 | 221489_s_at | 0.7279 | 0.0067 | |
| GSE97050 | SPRY4 | 81848 | A_33_P3338423 | 0.5698 | 0.2289 | |
| SRP007169 | SPRY4 | 81848 | RNAseq | 3.2952 | 0.0000 | |
| SRP008496 | SPRY4 | 81848 | RNAseq | 2.6052 | 0.0000 | |
| SRP064894 | SPRY4 | 81848 | RNAseq | 1.5425 | 0.0000 | |
| SRP133303 | SPRY4 | 81848 | RNAseq | 1.6179 | 0.0000 | |
| SRP159526 | SPRY4 | 81848 | RNAseq | 2.0417 | 0.0000 | |
| SRP193095 | SPRY4 | 81848 | RNAseq | 1.3103 | 0.0000 | |
| SRP219564 | SPRY4 | 81848 | RNAseq | 0.8270 | 0.1702 | |
| TCGA | SPRY4 | 81848 | RNAseq | -0.0275 | 0.7798 |
Upregulated datasets: 7; Downregulated datasets: 0.
Survival by SPRY4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SPRY4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SPRY4 | 81848 | 1 | 12 | 17 | |
| GSE20123 | SPRY4 | 81848 | 1 | 12 | 17 | |
| GSE43470 | SPRY4 | 81848 | 2 | 10 | 31 | |
| GSE46452 | SPRY4 | 81848 | 0 | 27 | 32 | |
| GSE47630 | SPRY4 | 81848 | 0 | 20 | 20 | |
| GSE54993 | SPRY4 | 81848 | 9 | 1 | 60 | |
| GSE54994 | SPRY4 | 81848 | 2 | 14 | 37 | |
| GSE60625 | SPRY4 | 81848 | 0 | 0 | 11 | |
| GSE74703 | SPRY4 | 81848 | 2 | 7 | 27 | |
| GSE74704 | SPRY4 | 81848 | 1 | 6 | 13 | |
| TCGA | SPRY4 | 81848 | 3 | 38 | 55 |
Total number of gains: 21; Total number of losses: 147; Total Number of normals: 320.
Somatic mutations of SPRY4:
Generating mutation plots.
Highly correlated genes for SPRY4:
Showing top 20/747 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SPRY4 | SPRY4-IT1 | 0.78085 | 5 | 0 | 5 |
| SPRY4 | SPRR2G | 0.741554 | 3 | 0 | 3 |
| SPRY4 | APLN | 0.714288 | 3 | 0 | 3 |
| SPRY4 | WDR54 | 0.713106 | 6 | 0 | 6 |
| SPRY4 | MUCL1 | 0.706886 | 3 | 0 | 3 |
| SPRY4 | LOXL2 | 0.678009 | 11 | 0 | 9 |
| SPRY4 | MB21D2 | 0.675051 | 4 | 0 | 4 |
| SPRY4 | PLEC | 0.674067 | 4 | 0 | 4 |
| SPRY4 | ADAMTS12 | 0.672464 | 8 | 0 | 8 |
| SPRY4 | FGFR1 | 0.667378 | 3 | 0 | 3 |
| SPRY4 | COL4A2 | 0.665286 | 12 | 0 | 12 |
| SPRY4 | FMNL2 | 0.662154 | 7 | 0 | 7 |
| SPRY4 | SLC12A2 | 0.66101 | 4 | 0 | 3 |
| SPRY4 | ABI2 | 0.656004 | 4 | 0 | 3 |
| SPRY4 | AGO2 | 0.654135 | 4 | 0 | 4 |
| SPRY4 | NEDD1 | 0.650591 | 4 | 0 | 3 |
| SPRY4 | SLAMF9 | 0.649851 | 4 | 0 | 3 |
| SPRY4 | ADAMTS15 | 0.649659 | 4 | 0 | 4 |
| SPRY4 | TUBA1B | 0.648981 | 5 | 0 | 4 |
| SPRY4 | CEBPB | 0.648633 | 10 | 0 | 9 |
For details and further investigation, click here
