| Full name: interleukin 11 receptor subunit alpha | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 9p13.3 | ||
| Entrez ID: 3590 | HGNC ID: HGNC:5967 | Ensembl Gene: ENSG00000137070 | OMIM ID: 600939 |
| Drug and gene relationship at DGIdb | |||
IL11RA involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04630 | Jak-STAT signaling pathway |
Expression of IL11RA:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | IL11RA | 3590 | 204773_at | -1.0020 | 0.0952 | |
| GSE20347 | IL11RA | 3590 | 204773_at | -0.5258 | 0.0022 | |
| GSE23400 | IL11RA | 3590 | 204773_at | -0.2454 | 0.0116 | |
| GSE26886 | IL11RA | 3590 | 204773_at | 0.1253 | 0.4417 | |
| GSE29001 | IL11RA | 3590 | 204773_at | -0.3186 | 0.1367 | |
| GSE38129 | IL11RA | 3590 | 204773_at | -0.8971 | 0.0001 | |
| GSE45670 | IL11RA | 3590 | 204773_at | -1.0428 | 0.0000 | |
| GSE53622 | IL11RA | 3590 | 37966 | -2.1214 | 0.0000 | |
| GSE53624 | IL11RA | 3590 | 37966 | -2.3274 | 0.0000 | |
| GSE63941 | IL11RA | 3590 | 204773_at | -1.3115 | 0.0387 | |
| GSE77861 | IL11RA | 3590 | 1552646_at | -0.0748 | 0.5236 | |
| GSE97050 | IL11RA | 3590 | A_23_P71867 | -1.1089 | 0.1482 | |
| SRP064894 | IL11RA | 3590 | RNAseq | -0.1746 | 0.5780 | |
| SRP133303 | IL11RA | 3590 | RNAseq | -1.1757 | 0.0000 | |
| SRP159526 | IL11RA | 3590 | RNAseq | -1.0116 | 0.0105 | |
| SRP193095 | IL11RA | 3590 | RNAseq | -0.1250 | 0.4963 | |
| SRP219564 | IL11RA | 3590 | RNAseq | -0.1902 | 0.6319 | |
| TCGA | IL11RA | 3590 | RNAseq | -0.6789 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 6.
Survival by IL11RA expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of IL11RA:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | IL11RA | 3590 | 4 | 13 | 13 | |
| GSE20123 | IL11RA | 3590 | 4 | 13 | 13 | |
| GSE43470 | IL11RA | 3590 | 3 | 10 | 30 | |
| GSE46452 | IL11RA | 3590 | 6 | 15 | 38 | |
| GSE47630 | IL11RA | 3590 | 1 | 20 | 19 | |
| GSE54993 | IL11RA | 3590 | 6 | 0 | 64 | |
| GSE54994 | IL11RA | 3590 | 6 | 12 | 35 | |
| GSE60625 | IL11RA | 3590 | 0 | 0 | 11 | |
| GSE74703 | IL11RA | 3590 | 2 | 7 | 27 | |
| GSE74704 | IL11RA | 3590 | 0 | 11 | 9 | |
| TCGA | IL11RA | 3590 | 17 | 44 | 35 |
Total number of gains: 49; Total number of losses: 145; Total Number of normals: 294.
Somatic mutations of IL11RA:
Generating mutation plots.
Highly correlated genes for IL11RA:
Showing top 20/927 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| IL11RA | LYNX1 | 0.850348 | 3 | 0 | 3 |
| IL11RA | MYZAP | 0.823584 | 3 | 0 | 3 |
| IL11RA | KRTAP20-1 | 0.805651 | 3 | 0 | 3 |
| IL11RA | NCCRP1 | 0.801232 | 3 | 0 | 3 |
| IL11RA | OR2Z1 | 0.796744 | 3 | 0 | 3 |
| IL11RA | FIBIN | 0.770182 | 3 | 0 | 3 |
| IL11RA | RAET1E | 0.763813 | 3 | 0 | 3 |
| IL11RA | GPX6 | 0.761835 | 3 | 0 | 3 |
| IL11RA | OMD | 0.761623 | 3 | 0 | 3 |
| IL11RA | RASSF8-AS1 | 0.756056 | 3 | 0 | 3 |
| IL11RA | ABHD14A | 0.749615 | 3 | 0 | 3 |
| IL11RA | KPRP | 0.747648 | 3 | 0 | 3 |
| IL11RA | TECPR1 | 0.744555 | 4 | 0 | 4 |
| IL11RA | FAM163B | 0.743613 | 3 | 0 | 3 |
| IL11RA | FGFR1 | 0.730972 | 3 | 0 | 3 |
| IL11RA | RGS7BP | 0.726577 | 4 | 0 | 4 |
| IL11RA | UPK3B | 0.72603 | 3 | 0 | 3 |
| IL11RA | VSIG2 | 0.725889 | 4 | 0 | 3 |
| IL11RA | MFSD2B | 0.72488 | 3 | 0 | 3 |
| IL11RA | VSIG10L | 0.723922 | 4 | 0 | 3 |
For details and further investigation, click here
