| Full name: forkhead box O4 | Alias Symbol: AFX1 | ||
| Type: protein-coding gene | Cytoband: Xq13.1 | ||
| Entrez ID: 4303 | HGNC ID: HGNC:7139 | Ensembl Gene: ENSG00000184481 | OMIM ID: 300033 |
| Drug and gene relationship at DGIdb | |||
FOXO4 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04014 | Ras signaling pathway | |
| hsa04068 | FoxO signaling pathway |
Expression of FOXO4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | FOXO4 | 4303 | 205451_at | -0.3222 | 0.1768 | |
| GSE20347 | FOXO4 | 4303 | 205451_at | -0.2591 | 0.0048 | |
| GSE23400 | FOXO4 | 4303 | 205451_at | -0.1357 | 0.0004 | |
| GSE26886 | FOXO4 | 4303 | 205451_at | 0.0923 | 0.5096 | |
| GSE29001 | FOXO4 | 4303 | 205451_at | -0.4391 | 0.0542 | |
| GSE38129 | FOXO4 | 4303 | 205451_at | -0.3871 | 0.0004 | |
| GSE45670 | FOXO4 | 4303 | 205451_at | -0.3618 | 0.0035 | |
| GSE53622 | FOXO4 | 4303 | 94218 | -0.5628 | 0.0000 | |
| GSE53624 | FOXO4 | 4303 | 26396 | -1.2847 | 0.0000 | |
| GSE63941 | FOXO4 | 4303 | 205451_at | 0.3369 | 0.1245 | |
| GSE77861 | FOXO4 | 4303 | 205451_at | -0.1788 | 0.4834 | |
| GSE97050 | FOXO4 | 4303 | A_33_P3249793 | -0.2194 | 0.5187 | |
| SRP007169 | FOXO4 | 4303 | RNAseq | -1.4403 | 0.0015 | |
| SRP064894 | FOXO4 | 4303 | RNAseq | -0.6596 | 0.0001 | |
| SRP133303 | FOXO4 | 4303 | RNAseq | -0.6715 | 0.0554 | |
| SRP159526 | FOXO4 | 4303 | RNAseq | -1.1355 | 0.0000 | |
| SRP193095 | FOXO4 | 4303 | RNAseq | -1.0400 | 0.0000 | |
| SRP219564 | FOXO4 | 4303 | RNAseq | -1.0764 | 0.0288 | |
| TCGA | FOXO4 | 4303 | RNAseq | -0.4170 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 5.
Survival by FOXO4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of FOXO4:
No record found for this gene.
Somatic mutations of FOXO4:
Generating mutation plots.
Highly correlated genes for FOXO4:
Showing top 20/484 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| FOXO4 | GALR2 | 0.702318 | 3 | 0 | 3 |
| FOXO4 | PGC | 0.702176 | 3 | 0 | 3 |
| FOXO4 | PLCD4 | 0.695986 | 4 | 0 | 4 |
| FOXO4 | UCK1 | 0.681066 | 3 | 0 | 3 |
| FOXO4 | MOB2 | 0.67245 | 6 | 0 | 5 |
| FOXO4 | ZNF444 | 0.672307 | 4 | 0 | 3 |
| FOXO4 | TAMM41 | 0.669443 | 3 | 0 | 3 |
| FOXO4 | UBXN6 | 0.663879 | 3 | 0 | 3 |
| FOXO4 | PEG3-AS1 | 0.662334 | 3 | 0 | 3 |
| FOXO4 | HRCT1 | 0.661044 | 4 | 0 | 4 |
| FOXO4 | SMDT1 | 0.657172 | 3 | 0 | 3 |
| FOXO4 | C20orf141 | 0.656716 | 4 | 0 | 3 |
| FOXO4 | HIF3A | 0.655387 | 6 | 0 | 5 |
| FOXO4 | ARHGAP30 | 0.654065 | 5 | 0 | 5 |
| FOXO4 | ADAP1 | 0.653941 | 3 | 0 | 3 |
| FOXO4 | PRRT2 | 0.650652 | 5 | 0 | 3 |
| FOXO4 | SPRYD3 | 0.648447 | 3 | 0 | 3 |
| FOXO4 | SNAP91 | 0.648097 | 3 | 0 | 3 |
| FOXO4 | S1PR2 | 0.644664 | 3 | 0 | 3 |
| FOXO4 | ITGB1BP2 | 0.643306 | 6 | 0 | 5 |
For details and further investigation, click here
