| Full name: sphingosine-1-phosphate receptor 2 | Alias Symbol: Gpcr13|H218|AGR16 | ||
| Type: protein-coding gene | Cytoband: 19p13.2 | ||
| Entrez ID: 9294 | HGNC ID: HGNC:3169 | Ensembl Gene: ENSG00000267534 | OMIM ID: 605111 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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S1PR2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04071 | Sphingolipid signaling pathway |
Expression of S1PR2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | S1PR2 | 9294 | 227684_at | 0.1329 | 0.7330 | |
| GSE20347 | S1PR2 | 9294 | 208537_at | 0.0281 | 0.6332 | |
| GSE23400 | S1PR2 | 9294 | 208537_at | -0.0673 | 0.1094 | |
| GSE26886 | S1PR2 | 9294 | 227684_at | 0.3725 | 0.0405 | |
| GSE29001 | S1PR2 | 9294 | 208537_at | 0.0598 | 0.6977 | |
| GSE38129 | S1PR2 | 9294 | 208537_at | -0.0520 | 0.4428 | |
| GSE45670 | S1PR2 | 9294 | 227684_at | -0.1049 | 0.2705 | |
| GSE63941 | S1PR2 | 9294 | 227684_at | -1.5762 | 0.0000 | |
| GSE77861 | S1PR2 | 9294 | 227684_at | -0.1085 | 0.4687 | |
| GSE97050 | S1PR2 | 9294 | A_32_P827528 | 0.1068 | 0.6672 | |
| SRP007169 | S1PR2 | 9294 | RNAseq | 0.6648 | 0.1752 | |
| SRP008496 | S1PR2 | 9294 | RNAseq | 0.8603 | 0.0142 | |
| SRP064894 | S1PR2 | 9294 | RNAseq | 0.9209 | 0.0055 | |
| SRP133303 | S1PR2 | 9294 | RNAseq | 0.1192 | 0.4720 | |
| SRP159526 | S1PR2 | 9294 | RNAseq | 0.3775 | 0.4400 | |
| SRP193095 | S1PR2 | 9294 | RNAseq | 0.6508 | 0.0000 | |
| SRP219564 | S1PR2 | 9294 | RNAseq | 1.3541 | 0.0076 | |
| TCGA | S1PR2 | 9294 | RNAseq | -0.0535 | 0.5136 |
Upregulated datasets: 1; Downregulated datasets: 1.
Survival by S1PR2 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of S1PR2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | S1PR2 | 9294 | 4 | 3 | 23 | |
| GSE20123 | S1PR2 | 9294 | 3 | 1 | 26 | |
| GSE43470 | S1PR2 | 9294 | 3 | 6 | 34 | |
| GSE46452 | S1PR2 | 9294 | 47 | 1 | 11 | |
| GSE47630 | S1PR2 | 9294 | 4 | 7 | 29 | |
| GSE54993 | S1PR2 | 9294 | 16 | 3 | 51 | |
| GSE54994 | S1PR2 | 9294 | 7 | 13 | 33 | |
| GSE60625 | S1PR2 | 9294 | 9 | 0 | 2 | |
| GSE74703 | S1PR2 | 9294 | 3 | 4 | 29 | |
| GSE74704 | S1PR2 | 9294 | 0 | 1 | 19 | |
| TCGA | S1PR2 | 9294 | 13 | 15 | 68 |
Total number of gains: 109; Total number of losses: 54; Total Number of normals: 325.
Somatic mutations of S1PR2:
Generating mutation plots.
Highly correlated genes for S1PR2:
Showing top 20/492 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| S1PR2 | RFX3 | 0.730659 | 3 | 0 | 3 |
| S1PR2 | ST6GALNAC3 | 0.724682 | 3 | 0 | 3 |
| S1PR2 | ALX3 | 0.693383 | 3 | 0 | 3 |
| S1PR2 | ATOH8 | 0.686852 | 3 | 0 | 3 |
| S1PR2 | DAB1 | 0.686041 | 5 | 0 | 4 |
| S1PR2 | KBTBD8 | 0.683217 | 3 | 0 | 3 |
| S1PR2 | TMEM170B | 0.681932 | 3 | 0 | 3 |
| S1PR2 | DEFA4 | 0.677049 | 4 | 0 | 4 |
| S1PR2 | CCL22 | 0.676905 | 3 | 0 | 3 |
| S1PR2 | FOXD3 | 0.676281 | 3 | 0 | 3 |
| S1PR2 | LRFN5 | 0.674078 | 3 | 0 | 3 |
| S1PR2 | LZTS1 | 0.665573 | 4 | 0 | 3 |
| S1PR2 | WTIP | 0.660978 | 5 | 0 | 5 |
| S1PR2 | ZNF804A | 0.658442 | 4 | 0 | 3 |
| S1PR2 | TMEM119 | 0.65625 | 4 | 0 | 4 |
| S1PR2 | PTTG1IP | 0.654462 | 3 | 0 | 3 |
| S1PR2 | STS | 0.652277 | 4 | 0 | 4 |
| S1PR2 | ENHO | 0.651086 | 3 | 0 | 3 |
| S1PR2 | SLC9B2 | 0.647599 | 3 | 0 | 3 |
| S1PR2 | TRAM1L1 | 0.64586 | 3 | 0 | 3 |
For details and further investigation, click here
