| Full name: proline rich transmembrane protein 2 | Alias Symbol: FLJ25513|DKFZp547J199|IFITMD1|FICCA|DSPB3|PKC|EKD1 | ||
| Type: protein-coding gene | Cytoband: 16p11.2 | ||
| Entrez ID: 112476 | HGNC ID: HGNC:30500 | Ensembl Gene: ENSG00000167371 | OMIM ID: 614386 |
| Drug and gene relationship at DGIdb | |||
Expression of PRRT2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PRRT2 | 112476 | 227192_at | -0.5531 | 0.3883 | |
| GSE26886 | PRRT2 | 112476 | 227192_at | 0.4436 | 0.0052 | |
| GSE45670 | PRRT2 | 112476 | 227192_at | -0.8813 | 0.0001 | |
| GSE53622 | PRRT2 | 112476 | 89110 | -0.1766 | 0.1101 | |
| GSE53624 | PRRT2 | 112476 | 89110 | -0.2912 | 0.0023 | |
| GSE63941 | PRRT2 | 112476 | 227192_at | -0.0760 | 0.7356 | |
| GSE77861 | PRRT2 | 112476 | 227192_at | -0.0060 | 0.9833 | |
| GSE97050 | PRRT2 | 112476 | A_23_P66017 | -1.0327 | 0.1666 | |
| SRP064894 | PRRT2 | 112476 | RNAseq | -0.9917 | 0.0017 | |
| SRP133303 | PRRT2 | 112476 | RNAseq | -0.5097 | 0.0482 | |
| SRP159526 | PRRT2 | 112476 | RNAseq | -0.1837 | 0.7534 | |
| SRP193095 | PRRT2 | 112476 | RNAseq | 0.2442 | 0.2822 | |
| SRP219564 | PRRT2 | 112476 | RNAseq | -0.4802 | 0.3871 | |
| TCGA | PRRT2 | 112476 | RNAseq | -0.6029 | 0.0011 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by PRRT2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PRRT2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PRRT2 | 112476 | 5 | 5 | 20 | |
| GSE20123 | PRRT2 | 112476 | 5 | 4 | 21 | |
| GSE43470 | PRRT2 | 112476 | 3 | 3 | 37 | |
| GSE46452 | PRRT2 | 112476 | 38 | 1 | 20 | |
| GSE47630 | PRRT2 | 112476 | 11 | 7 | 22 | |
| GSE54993 | PRRT2 | 112476 | 3 | 5 | 62 | |
| GSE54994 | PRRT2 | 112476 | 5 | 9 | 39 | |
| GSE60625 | PRRT2 | 112476 | 4 | 0 | 7 | |
| GSE74703 | PRRT2 | 112476 | 3 | 2 | 31 | |
| GSE74704 | PRRT2 | 112476 | 3 | 2 | 15 | |
| TCGA | PRRT2 | 112476 | 20 | 11 | 65 |
Total number of gains: 100; Total number of losses: 49; Total Number of normals: 339.
Somatic mutations of PRRT2:
Generating mutation plots.
Highly correlated genes for PRRT2:
Showing top 20/293 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PRRT2 | ANKDD1A | 0.789521 | 3 | 0 | 3 |
| PRRT2 | HRC | 0.768313 | 3 | 0 | 3 |
| PRRT2 | LAMA2 | 0.756492 | 3 | 0 | 3 |
| PRRT2 | SPTBN4 | 0.729709 | 3 | 0 | 3 |
| PRRT2 | MFAP4 | 0.723169 | 3 | 0 | 3 |
| PRRT2 | SHISA4 | 0.723004 | 4 | 0 | 4 |
| PRRT2 | VCX2 | 0.717852 | 3 | 0 | 3 |
| PRRT2 | LAT | 0.716379 | 3 | 0 | 3 |
| PRRT2 | CACNA1H | 0.712324 | 4 | 0 | 4 |
| PRRT2 | TCEAL7 | 0.704078 | 4 | 0 | 4 |
| PRRT2 | KCNT2 | 0.703237 | 3 | 0 | 3 |
| PRRT2 | NPY | 0.70101 | 3 | 0 | 3 |
| PRRT2 | SDHAF1 | 0.700872 | 3 | 0 | 3 |
| PRRT2 | PYGB | 0.696889 | 3 | 0 | 3 |
| PRRT2 | MITF | 0.696409 | 4 | 0 | 4 |
| PRRT2 | IL17B | 0.691702 | 4 | 0 | 3 |
| PRRT2 | ARVCF | 0.691095 | 3 | 0 | 3 |
| PRRT2 | MGAT5B | 0.688465 | 3 | 0 | 3 |
| PRRT2 | MAPK8IP2 | 0.687167 | 3 | 0 | 3 |
| PRRT2 | PHF21A | 0.685642 | 4 | 0 | 4 |
For details and further investigation, click here
