FUBP1

 

Full name: far upstream element binding protein 1 Alias Symbol: FBP
Type: protein-coding gene Cytoband: 1p31.1
Entrez ID: 8880 HGNC ID: HGNC:4004 Ensembl Gene: ENSG00000162613 OMIM ID: 603444
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found 68/325 cell lines had fitness change in Project Score.
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of FUBP1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 FUBP1 8880 214093_s_at 0.1405 0.8142
GSE20347 FUBP1 8880 203091_at 0.5083 0.0000
GSE23400 FUBP1 8880 203091_at 0.4361 0.0000
GSE26886 FUBP1 8880 203091_at -0.1013 0.3496
GSE29001 FUBP1 8880 214093_s_at 0.1749 0.6324
GSE38129 FUBP1 8880 203091_at 0.5032 0.0000
GSE45670 FUBP1 8880 203091_at 0.4273 0.0024
GSE53622 FUBP1 8880 116068 0.8470 0.0000
GSE53624 FUBP1 8880 15880 0.6942 0.0000
GSE63941 FUBP1 8880 203091_at 0.4355 0.1290
GSE77861 FUBP1 8880 203091_at 0.2233 0.1187
GSE97050 FUBP1 8880 A_33_P3281151 0.3472 0.2290
SRP007169 FUBP1 8880 RNAseq 0.9033 0.0121
SRP008496 FUBP1 8880 RNAseq 0.8268 0.0000
SRP064894 FUBP1 8880 RNAseq 0.4239 0.0456
SRP133303 FUBP1 8880 RNAseq 0.3864 0.0017
SRP159526 FUBP1 8880 RNAseq 0.2193 0.1901
SRP193095 FUBP1 8880 RNAseq 0.2164 0.0040
SRP219564 FUBP1 8880 RNAseq 0.5437 0.2003
TCGA FUBP1 8880 RNAseq 0.1180 0.0126

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by FUBP1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of FUBP1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 FUBP1 8880 0 7 23
GSE20123 FUBP1 8880 0 7 23
GSE43470 FUBP1 8880 4 4 35
GSE46452 FUBP1 8880 0 1 58
GSE47630 FUBP1 8880 8 6 26
GSE54993 FUBP1 8880 0 0 70
GSE54994 FUBP1 8880 6 3 44
GSE60625 FUBP1 8880 0 0 11
GSE74703 FUBP1 8880 3 3 30
GSE74704 FUBP1 8880 0 4 16
TCGA FUBP1 8880 8 25 63

Total number of gains: 29; Total number of losses: 60; Total Number of normals: 399.  

 

Somatic mutations of FUBP1:

 

Generating mutation plots.

 

Highly correlated genes for FUBP1:

 

Showing top 20/1128 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
FUBP1ZBTB90.803817404
FUBP1ZNF7870.799349303
FUBP1PRTFDC10.796728303
FUBP1LENG80.785382303
FUBP1SLC39A30.780122303
FUBP1CCDC140.776536303
FUBP1LRIG20.77546505
FUBP1SAAL10.765972303
FUBP1GTF2H30.761138303
FUBP1GNG100.74671303
FUBP1RPS190.739713303
FUBP1GPR1530.739706303
FUBP1SLC7A6OS0.736308303
FUBP1BOD10.73288505
FUBP1NBN0.732765303
FUBP1GLS0.732595404
FUBP1NEDD10.732516404
FUBP1FMNL20.731438404
FUBP1ZNF2840.728679303
FUBP1ELOF10.72595303

For details and further investigation, click here