| Full name: nibrin | Alias Symbol: ATV|AT-V2|AT-V1 | ||
| Type: protein-coding gene | Cytoband: 8q21.3 | ||
| Entrez ID: 4683 | HGNC ID: HGNC:7652 | Ensembl Gene: ENSG00000104320 | OMIM ID: 602667 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of NBN:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NBN | 4683 | 202907_s_at | 0.3273 | 0.5183 | |
| GSE20347 | NBN | 4683 | 202907_s_at | 0.2500 | 0.2675 | |
| GSE23400 | NBN | 4683 | 202907_s_at | 0.2616 | 0.0089 | |
| GSE26886 | NBN | 4683 | 202907_s_at | -0.8716 | 0.0013 | |
| GSE29001 | NBN | 4683 | 202907_s_at | 0.3673 | 0.1429 | |
| GSE38129 | NBN | 4683 | 202907_s_at | 0.0110 | 0.9599 | |
| GSE45670 | NBN | 4683 | 202907_s_at | 0.0664 | 0.7236 | |
| GSE53622 | NBN | 4683 | 91723 | 0.1441 | 0.1052 | |
| GSE53624 | NBN | 4683 | 91723 | 0.1333 | 0.2667 | |
| GSE63941 | NBN | 4683 | 202907_s_at | -0.5732 | 0.3161 | |
| GSE77861 | NBN | 4683 | 202907_s_at | -0.1166 | 0.7497 | |
| GSE97050 | NBN | 4683 | A_24_P278126 | -0.2834 | 0.3917 | |
| SRP007169 | NBN | 4683 | RNAseq | 0.0288 | 0.9316 | |
| SRP008496 | NBN | 4683 | RNAseq | 0.1168 | 0.5580 | |
| SRP064894 | NBN | 4683 | RNAseq | 0.5416 | 0.0122 | |
| SRP133303 | NBN | 4683 | RNAseq | 0.5230 | 0.0050 | |
| SRP159526 | NBN | 4683 | RNAseq | 0.0458 | 0.8317 | |
| SRP193095 | NBN | 4683 | RNAseq | 0.0627 | 0.5978 | |
| SRP219564 | NBN | 4683 | RNAseq | 0.4081 | 0.3209 | |
| TCGA | NBN | 4683 | RNAseq | 0.0848 | 0.1071 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by NBN expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NBN:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NBN | 4683 | 14 | 1 | 15 | |
| GSE20123 | NBN | 4683 | 15 | 1 | 14 | |
| GSE43470 | NBN | 4683 | 20 | 1 | 22 | |
| GSE46452 | NBN | 4683 | 22 | 0 | 37 | |
| GSE47630 | NBN | 4683 | 24 | 0 | 16 | |
| GSE54993 | NBN | 4683 | 0 | 20 | 50 | |
| GSE54994 | NBN | 4683 | 33 | 1 | 19 | |
| GSE60625 | NBN | 4683 | 0 | 4 | 7 | |
| GSE74703 | NBN | 4683 | 17 | 1 | 18 | |
| GSE74704 | NBN | 4683 | 10 | 0 | 10 | |
| TCGA | NBN | 4683 | 56 | 1 | 39 |
Total number of gains: 211; Total number of losses: 30; Total Number of normals: 247.
Somatic mutations of NBN:
Generating mutation plots.
Highly correlated genes for NBN:
Showing top 20/320 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NBN | AP3M1 | 0.775377 | 3 | 0 | 3 |
| NBN | MYLIP | 0.769047 | 3 | 0 | 3 |
| NBN | ARL5B | 0.762665 | 3 | 0 | 3 |
| NBN | SETX | 0.760412 | 3 | 0 | 3 |
| NBN | ACADSB | 0.75048 | 3 | 0 | 3 |
| NBN | FAM76A | 0.741389 | 3 | 0 | 3 |
| NBN | WDFY1 | 0.741046 | 3 | 0 | 3 |
| NBN | NUDT15 | 0.736533 | 3 | 0 | 3 |
| NBN | MRPL1 | 0.733744 | 3 | 0 | 3 |
| NBN | FUBP1 | 0.732765 | 3 | 0 | 3 |
| NBN | NFKB1 | 0.726867 | 4 | 0 | 4 |
| NBN | RCOR3 | 0.724606 | 3 | 0 | 3 |
| NBN | SCAI | 0.716781 | 4 | 0 | 3 |
| NBN | NHS | 0.716606 | 3 | 0 | 3 |
| NBN | TLR3 | 0.713056 | 3 | 0 | 3 |
| NBN | UFM1 | 0.710356 | 3 | 0 | 3 |
| NBN | RAB28 | 0.710171 | 3 | 0 | 3 |
| NBN | CNOT6L | 0.707495 | 3 | 0 | 3 |
| NBN | BIRC2 | 0.705088 | 3 | 0 | 3 |
| NBN | TRAPPC2 | 0.702912 | 4 | 0 | 3 |
For details and further investigation, click here
