PAX8

 

Full name: paired box 8 Alias Symbol: 
Type: protein-coding gene Cytoband: 2q14.1
Entrez ID: 7849 HGNC ID: HGNC:8622 Ensembl Gene: ENSG00000125618 OMIM ID: 167415
Drug and gene relationship at DGIdb
Screen Evidence:

 

PAX8 involved pathways:

KEGG pathway Description View
hsa04918Thyroid hormone synthesis

 

Expression of PAX8:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 PAX8 7849 121_at -0.3120 0.3049
GSE20347 PAX8 7849 121_at -0.3400 0.0138
GSE23400 PAX8 7849 121_at -0.2739 0.0000
GSE26886 PAX8 7849 121_at -0.0934 0.7482
GSE29001 PAX8 7849 121_at -0.3638 0.1330
GSE38129 PAX8 7849 121_at -0.4418 0.0005
GSE45670 PAX8 7849 121_at -0.0723 0.7364
GSE53622 PAX8 7849 62465 -0.0059 0.9443
GSE53624 PAX8 7849 62465 0.1804 0.0723
GSE63941 PAX8 7849 121_at 0.3478 0.0360
GSE77861 PAX8 7849 121_at -0.2926 0.0089
GSE97050 PAX8 7849 A_33_P3234809 -0.0221 0.9310
SRP007169 PAX8 7849 RNAseq -1.6223 0.0641
SRP133303 PAX8 7849 RNAseq -0.5784 0.1723
SRP159526 PAX8 7849 RNAseq 0.3811 0.6215
SRP193095 PAX8 7849 RNAseq -0.0818 0.7731
SRP219564 PAX8 7849 RNAseq -0.6014 0.3586
TCGA PAX8 7849 RNAseq 0.1712 0.5037

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by PAX8 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of PAX8:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 PAX8 7849 7 2 21
GSE20123 PAX8 7849 7 2 21
GSE43470 PAX8 7849 3 1 39
GSE46452 PAX8 7849 1 4 54
GSE47630 PAX8 7849 6 0 34
GSE54993 PAX8 7849 0 6 64
GSE54994 PAX8 7849 10 2 41
GSE60625 PAX8 7849 0 3 8
GSE74703 PAX8 7849 3 1 32
GSE74704 PAX8 7849 3 2 15
TCGA PAX8 7849 31 6 59

Total number of gains: 71; Total number of losses: 29; Total Number of normals: 388.  

 

Somatic mutations of PAX8:

 

Generating mutation plots.

 

Highly correlated genes for PAX8:

 

Showing top 20/1011 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
PAX8PTPRN20.771077606
PAX8TMEM1250.764207303
PAX8LENG90.746851303
PAX8SLC22A250.723578303
PAX8KRT20.722895707
PAX8ADAMTS170.722556303
PAX8MC5R0.716376606
PAX8CLEC12B0.71414303
PAX8SCGB1A10.713114303
PAX8ADH60.709708808
PAX8HAAO0.709673808
PAX8OTOG0.709601303
PAX8C4BPB0.696865606
PAX8APOM0.69428606
PAX8DNAH60.692413707
PAX8PIWIL20.690397807
PAX8KRT320.689039706
PAX8IL9R0.688736606
PAX8PLA2G2C0.686565303
PAX8LMAN1L0.685404808

For details and further investigation, click here