| Full name: RAB27B, member RAS oncogene family | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 18q21.2 | ||
| Entrez ID: 5874 | HGNC ID: HGNC:9767 | Ensembl Gene: ENSG00000041353 | OMIM ID: 603869 |
| Drug and gene relationship at DGIdb | |||
Expression of RAB27B:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RAB27B | 5874 | 228708_at | -0.8552 | 0.5359 | |
| GSE20347 | RAB27B | 5874 | 207018_s_at | -1.5145 | 0.0000 | |
| GSE23400 | RAB27B | 5874 | 207018_s_at | -0.2383 | 0.0000 | |
| GSE26886 | RAB27B | 5874 | 228708_at | -2.4624 | 0.0000 | |
| GSE29001 | RAB27B | 5874 | 207018_s_at | -0.9249 | 0.0334 | |
| GSE38129 | RAB27B | 5874 | 207018_s_at | -1.2445 | 0.0000 | |
| GSE45670 | RAB27B | 5874 | 228708_at | -0.3133 | 0.3638 | |
| GSE53622 | RAB27B | 5874 | 10150 | -1.5317 | 0.0000 | |
| GSE53624 | RAB27B | 5874 | 10150 | -1.5561 | 0.0000 | |
| GSE63941 | RAB27B | 5874 | 228708_at | -2.4208 | 0.0861 | |
| GSE77861 | RAB27B | 5874 | 228708_at | -1.4969 | 0.0094 | |
| GSE97050 | RAB27B | 5874 | A_23_P107612 | 0.3572 | 0.6195 | |
| SRP007169 | RAB27B | 5874 | RNAseq | -3.4520 | 0.0000 | |
| SRP008496 | RAB27B | 5874 | RNAseq | -3.1711 | 0.0000 | |
| SRP064894 | RAB27B | 5874 | RNAseq | -1.8568 | 0.0000 | |
| SRP133303 | RAB27B | 5874 | RNAseq | -1.2563 | 0.0002 | |
| SRP159526 | RAB27B | 5874 | RNAseq | -2.8542 | 0.0000 | |
| SRP193095 | RAB27B | 5874 | RNAseq | -1.7833 | 0.0000 | |
| SRP219564 | RAB27B | 5874 | RNAseq | -2.3285 | 0.0176 | |
| TCGA | RAB27B | 5874 | RNAseq | -0.4458 | 0.0120 |
Upregulated datasets: 0; Downregulated datasets: 13.
Survival by RAB27B expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RAB27B:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RAB27B | 5874 | 2 | 9 | 19 | |
| GSE20123 | RAB27B | 5874 | 2 | 9 | 19 | |
| GSE43470 | RAB27B | 5874 | 0 | 5 | 38 | |
| GSE46452 | RAB27B | 5874 | 1 | 26 | 32 | |
| GSE47630 | RAB27B | 5874 | 5 | 20 | 15 | |
| GSE54993 | RAB27B | 5874 | 10 | 0 | 60 | |
| GSE54994 | RAB27B | 5874 | 1 | 17 | 35 | |
| GSE60625 | RAB27B | 5874 | 0 | 4 | 7 | |
| GSE74703 | RAB27B | 5874 | 0 | 5 | 31 | |
| GSE74704 | RAB27B | 5874 | 2 | 6 | 12 | |
| TCGA | RAB27B | 5874 | 10 | 43 | 43 |
Total number of gains: 33; Total number of losses: 144; Total Number of normals: 311.
Somatic mutations of RAB27B:
Generating mutation plots.
Highly correlated genes for RAB27B:
Showing top 20/1445 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RAB27B | HDHD2 | 0.858043 | 3 | 0 | 3 |
| RAB27B | RBM47 | 0.807929 | 11 | 0 | 11 |
| RAB27B | TMEM154 | 0.799415 | 7 | 0 | 7 |
| RAB27B | EHF | 0.784922 | 11 | 0 | 10 |
| RAB27B | TAB3 | 0.782984 | 6 | 0 | 6 |
| RAB27B | C15orf48 | 0.782008 | 7 | 0 | 7 |
| RAB27B | CAPN14 | 0.780968 | 6 | 0 | 6 |
| RAB27B | MACC1 | 0.780317 | 7 | 0 | 7 |
| RAB27B | TMOD3 | 0.778347 | 11 | 0 | 11 |
| RAB27B | TMEM45B | 0.776719 | 6 | 0 | 6 |
| RAB27B | IL1RN | 0.77653 | 11 | 0 | 11 |
| RAB27B | RAB11A | 0.776459 | 10 | 0 | 10 |
| RAB27B | CXCR2 | 0.773436 | 10 | 0 | 10 |
| RAB27B | ZDHHC13 | 0.773125 | 11 | 0 | 11 |
| RAB27B | ARAP2 | 0.771958 | 3 | 0 | 3 |
| RAB27B | CYSRT1 | 0.771942 | 6 | 0 | 6 |
| RAB27B | C6orf132 | 0.770488 | 7 | 0 | 7 |
| RAB27B | ACPP | 0.770349 | 11 | 0 | 11 |
| RAB27B | SCEL | 0.769897 | 11 | 0 | 11 |
| RAB27B | DUOX1 | 0.769381 | 11 | 0 | 10 |
For details and further investigation, click here
