WDR59

 

Full name: WD repeat domain 59 Alias Symbol: FLJ12270
Type: protein-coding gene Cytoband: 16q23.1
Entrez ID: 79726 HGNC ID: HGNC:25706 Ensembl Gene: ENSG00000103091 OMIM ID: 617418
Drug and gene relationship at DGIdb
Screen Evidence:

 

WDR59 involved pathways:

KEGG pathway Description View
hsa04150mTOR signaling pathway

 

Expression of WDR59:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 WDR59 79726 218505_at 0.2101 0.5334
GSE20347 WDR59 79726 218505_at 0.2028 0.0410
GSE23400 WDR59 79726 218505_at -0.0208 0.8092
GSE26886 WDR59 79726 218505_at -0.4116 0.0125
GSE29001 WDR59 79726 218505_at 0.0465 0.8998
GSE38129 WDR59 79726 218505_at 0.2002 0.0430
GSE45670 WDR59 79726 218505_at 0.0645 0.6558
GSE53622 WDR59 79726 15543 -0.0207 0.8029
GSE53624 WDR59 79726 15543 -0.1422 0.0385
GSE63941 WDR59 79726 218505_at 0.1591 0.5878
GSE77861 WDR59 79726 218505_at 0.2785 0.1737
GSE97050 WDR59 79726 A_23_P206856 0.0734 0.7489
SRP007169 WDR59 79726 RNAseq -0.8875 0.0083
SRP008496 WDR59 79726 RNAseq -0.9395 0.0058
SRP064894 WDR59 79726 RNAseq -0.4942 0.0016
SRP133303 WDR59 79726 RNAseq -0.1519 0.4501
SRP159526 WDR59 79726 RNAseq -0.2882 0.1596
SRP193095 WDR59 79726 RNAseq 0.0197 0.8972
SRP219564 WDR59 79726 RNAseq -0.5608 0.0917
TCGA WDR59 79726 RNAseq 0.0084 0.8667

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by WDR59 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of WDR59:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 WDR59 79726 6 1 23
GSE20123 WDR59 79726 6 1 23
GSE43470 WDR59 79726 2 8 33
GSE46452 WDR59 79726 37 2 20
GSE47630 WDR59 79726 11 8 21
GSE54993 WDR59 79726 2 4 64
GSE54994 WDR59 79726 8 10 35
GSE60625 WDR59 79726 4 0 7
GSE74703 WDR59 79726 2 5 29
GSE74704 WDR59 79726 3 0 17
TCGA WDR59 79726 25 15 56

Total number of gains: 106; Total number of losses: 54; Total Number of normals: 328.  

 

Somatic mutations of WDR59:

 

Generating mutation plots.

 

Highly correlated genes for WDR59:

 

Showing top 20/207 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
WDR59INTS80.767742303
WDR59PDXDC10.763197303
WDR59NFXL10.76164303
WDR59ZNF6640.757401303
WDR59DPY19L30.751047303
WDR59ORC20.736271303
WDR59UCKL10.726762403
WDR59SUPT7L0.724628404
WDR59ASH2L0.720978303
WDR59CNOT100.713583303
WDR59GAA0.706085303
WDR59NIPBL0.705102303
WDR59SEC31B0.700843303
WDR59FBXO310.700779303
WDR59SUGP10.700341303
WDR59CACNA1B0.697915303
WDR59ZBTB330.684583303
WDR59POLR3D0.680793303
WDR59NTRK20.68079303
WDR59UBE4B0.674896403

For details and further investigation, click here