| Full name: growth associated protein 43 | Alias Symbol: B-50|PP46 | ||
| Type: protein-coding gene | Cytoband: 3q13.31 | ||
| Entrez ID: 2596 | HGNC ID: HGNC:4140 | Ensembl Gene: ENSG00000172020 | OMIM ID: 162060 |
| Drug and gene relationship at DGIdb | |||
Expression of GAP43:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GAP43 | 2596 | 216963_s_at | 0.0325 | 0.9204 | |
| GSE20347 | GAP43 | 2596 | 216963_s_at | 0.2236 | 0.0276 | |
| GSE23400 | GAP43 | 2596 | 216963_s_at | -0.0116 | 0.7603 | |
| GSE26886 | GAP43 | 2596 | 216963_s_at | 0.1476 | 0.2405 | |
| GSE29001 | GAP43 | 2596 | 216963_s_at | -0.1356 | 0.2665 | |
| GSE38129 | GAP43 | 2596 | 216963_s_at | 0.0855 | 0.4343 | |
| GSE45670 | GAP43 | 2596 | 216963_s_at | -0.0043 | 0.9703 | |
| GSE63941 | GAP43 | 2596 | 216963_s_at | 0.2286 | 0.4737 | |
| GSE77861 | GAP43 | 2596 | 216963_s_at | -0.0959 | 0.3353 | |
| GSE97050 | GAP43 | 2596 | A_23_P253446 | 0.1973 | 0.6537 | |
| SRP159526 | GAP43 | 2596 | RNAseq | 3.7871 | 0.0001 | |
| SRP219564 | GAP43 | 2596 | RNAseq | -0.0134 | 0.9911 | |
| TCGA | GAP43 | 2596 | RNAseq | 0.1653 | 0.7061 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by GAP43 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of GAP43:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GAP43 | 2596 | 16 | 0 | 14 | |
| GSE20123 | GAP43 | 2596 | 16 | 0 | 14 | |
| GSE43470 | GAP43 | 2596 | 21 | 1 | 21 | |
| GSE46452 | GAP43 | 2596 | 13 | 5 | 41 | |
| GSE47630 | GAP43 | 2596 | 15 | 6 | 19 | |
| GSE54993 | GAP43 | 2596 | 2 | 6 | 62 | |
| GSE54994 | GAP43 | 2596 | 29 | 4 | 20 | |
| GSE60625 | GAP43 | 2596 | 0 | 6 | 5 | |
| GSE74703 | GAP43 | 2596 | 17 | 1 | 18 | |
| GSE74704 | GAP43 | 2596 | 12 | 0 | 8 | |
| TCGA | GAP43 | 2596 | 53 | 8 | 35 |
Total number of gains: 194; Total number of losses: 37; Total Number of normals: 257.
Somatic mutations of GAP43:
Generating mutation plots.
Highly correlated genes for GAP43:
Showing top 20/285 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GAP43 | FAM167B | 0.780888 | 3 | 0 | 3 |
| GAP43 | APBB1IP | 0.733128 | 3 | 0 | 3 |
| GAP43 | AFMID | 0.71936 | 3 | 0 | 3 |
| GAP43 | ZBTB12 | 0.710267 | 3 | 0 | 3 |
| GAP43 | DMBT1 | 0.704507 | 4 | 0 | 3 |
| GAP43 | CYGB | 0.691953 | 3 | 0 | 3 |
| GAP43 | RAB40AL | 0.68337 | 3 | 0 | 3 |
| GAP43 | GNA13 | 0.680217 | 3 | 0 | 3 |
| GAP43 | MUL1 | 0.673492 | 3 | 0 | 3 |
| GAP43 | PNMT | 0.670131 | 4 | 0 | 4 |
| GAP43 | DOC2B | 0.669579 | 5 | 0 | 5 |
| GAP43 | FZD4 | 0.665903 | 3 | 0 | 3 |
| GAP43 | RGS8 | 0.664823 | 3 | 0 | 3 |
| GAP43 | FAXDC2 | 0.660342 | 3 | 0 | 3 |
| GAP43 | YPEL2 | 0.659073 | 3 | 0 | 3 |
| GAP43 | BCAS4 | 0.659048 | 3 | 0 | 3 |
| GAP43 | DPP4 | 0.65758 | 3 | 0 | 3 |
| GAP43 | SLC44A4 | 0.656294 | 3 | 0 | 3 |
| GAP43 | C12orf45 | 0.654327 | 3 | 0 | 3 |
| GAP43 | OS9 | 0.654072 | 4 | 0 | 3 |
For details and further investigation, click here
