| Full name: frizzled class receptor 4 | Alias Symbol: CD344 | ||
| Type: protein-coding gene | Cytoband: 11q14.2 | ||
| Entrez ID: 8322 | HGNC ID: HGNC:4042 | Ensembl Gene: ENSG00000174804 | OMIM ID: 604579 |
| Drug and gene relationship at DGIdb | |||
FZD4 involved pathways:
Expression of FZD4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | FZD4 | 8322 | 218665_at | -0.0880 | 0.8001 | |
| GSE20347 | FZD4 | 8322 | 218665_at | -0.1649 | 0.1275 | |
| GSE23400 | FZD4 | 8322 | 218665_at | -0.3258 | 0.0000 | |
| GSE26886 | FZD4 | 8322 | 218665_at | -0.0144 | 0.9363 | |
| GSE29001 | FZD4 | 8322 | 218665_at | -0.1702 | 0.4109 | |
| GSE38129 | FZD4 | 8322 | 218665_at | -0.6404 | 0.0082 | |
| GSE45670 | FZD4 | 8322 | 218665_at | -0.8507 | 0.0003 | |
| GSE53622 | FZD4 | 8322 | 156958 | -0.8696 | 0.0000 | |
| GSE53624 | FZD4 | 8322 | 156958 | -0.4069 | 0.0006 | |
| GSE63941 | FZD4 | 8322 | 218665_at | -3.4011 | 0.0000 | |
| GSE77861 | FZD4 | 8322 | 224337_s_at | -0.0310 | 0.8198 | |
| GSE97050 | FZD4 | 8322 | A_23_P64617 | -0.3908 | 0.2292 | |
| SRP007169 | FZD4 | 8322 | RNAseq | 0.9754 | 0.0375 | |
| SRP008496 | FZD4 | 8322 | RNAseq | 0.7138 | 0.0404 | |
| SRP064894 | FZD4 | 8322 | RNAseq | 0.5620 | 0.1086 | |
| SRP133303 | FZD4 | 8322 | RNAseq | -0.5271 | 0.0288 | |
| SRP159526 | FZD4 | 8322 | RNAseq | -0.6045 | 0.0799 | |
| SRP193095 | FZD4 | 8322 | RNAseq | 0.1370 | 0.4681 | |
| SRP219564 | FZD4 | 8322 | RNAseq | 0.3131 | 0.4968 | |
| TCGA | FZD4 | 8322 | RNAseq | -0.7638 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by FZD4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of FZD4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | FZD4 | 8322 | 4 | 9 | 17 | |
| GSE20123 | FZD4 | 8322 | 4 | 9 | 17 | |
| GSE43470 | FZD4 | 8322 | 3 | 4 | 36 | |
| GSE46452 | FZD4 | 8322 | 5 | 24 | 30 | |
| GSE47630 | FZD4 | 8322 | 2 | 19 | 19 | |
| GSE54993 | FZD4 | 8322 | 8 | 2 | 60 | |
| GSE54994 | FZD4 | 8322 | 6 | 18 | 29 | |
| GSE60625 | FZD4 | 8322 | 0 | 3 | 8 | |
| GSE74703 | FZD4 | 8322 | 2 | 3 | 31 | |
| GSE74704 | FZD4 | 8322 | 3 | 6 | 11 | |
| TCGA | FZD4 | 8322 | 16 | 38 | 42 |
Total number of gains: 53; Total number of losses: 135; Total Number of normals: 300.
Somatic mutations of FZD4:
Generating mutation plots.
Highly correlated genes for FZD4:
Showing top 20/1263 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| FZD4 | CYGB | 0.819418 | 3 | 0 | 3 |
| FZD4 | ZNF583 | 0.813328 | 3 | 0 | 3 |
| FZD4 | CYP2U1 | 0.8028 | 5 | 0 | 5 |
| FZD4 | A1BG | 0.78771 | 3 | 0 | 3 |
| FZD4 | STOML1 | 0.787221 | 3 | 0 | 3 |
| FZD4 | RFNG | 0.772443 | 3 | 0 | 3 |
| FZD4 | SGTB | 0.771832 | 3 | 0 | 3 |
| FZD4 | RCAN1 | 0.765999 | 3 | 0 | 3 |
| FZD4 | ST6GALNAC3 | 0.762441 | 6 | 0 | 6 |
| FZD4 | C1QTNF7 | 0.762353 | 4 | 0 | 4 |
| FZD4 | EMCN | 0.756301 | 6 | 0 | 6 |
| FZD4 | MRGPRF | 0.753092 | 6 | 0 | 6 |
| FZD4 | MAN1C1 | 0.751898 | 10 | 0 | 10 |
| FZD4 | EPHA3 | 0.748904 | 6 | 0 | 6 |
| FZD4 | CLEC3B | 0.748388 | 3 | 0 | 3 |
| FZD4 | TOB2 | 0.742685 | 3 | 0 | 3 |
| FZD4 | TMEM170B | 0.742372 | 5 | 0 | 5 |
| FZD4 | CLIP3 | 0.735056 | 10 | 0 | 9 |
| FZD4 | TCL1B | 0.735017 | 4 | 0 | 4 |
| FZD4 | TAC1 | 0.734821 | 3 | 0 | 3 |
For details and further investigation, click here
