| Full name: dipeptidyl peptidase 4 | Alias Symbol: DPPIV | ||
| Type: protein-coding gene | Cytoband: 2q24.2 | ||
| Entrez ID: 1803 | HGNC ID: HGNC:3009 | Ensembl Gene: ENSG00000197635 | OMIM ID: 102720 |
| Drug and gene relationship at DGIdb | |||
Expression of DPP4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DPP4 | 1803 | 203717_at | 0.2540 | 0.8057 | |
| GSE20347 | DPP4 | 1803 | 203716_s_at | 0.2973 | 0.0058 | |
| GSE23400 | DPP4 | 1803 | 203716_s_at | 0.0246 | 0.6074 | |
| GSE26886 | DPP4 | 1803 | 203716_s_at | 0.3799 | 0.0937 | |
| GSE29001 | DPP4 | 1803 | 203717_at | 0.2306 | 0.4476 | |
| GSE38129 | DPP4 | 1803 | 203716_s_at | 0.2193 | 0.0894 | |
| GSE45670 | DPP4 | 1803 | 203717_at | 0.4027 | 0.4563 | |
| GSE53622 | DPP4 | 1803 | 14851 | 1.1963 | 0.0000 | |
| GSE53624 | DPP4 | 1803 | 5007 | 1.0528 | 0.0000 | |
| GSE63941 | DPP4 | 1803 | 203716_s_at | -6.3209 | 0.0000 | |
| GSE77861 | DPP4 | 1803 | 203716_s_at | 0.1031 | 0.3716 | |
| GSE97050 | DPP4 | 1803 | A_33_P3287223 | 0.2755 | 0.3774 | |
| SRP007169 | DPP4 | 1803 | RNAseq | 4.2103 | 0.0001 | |
| SRP008496 | DPP4 | 1803 | RNAseq | 4.5355 | 0.0000 | |
| SRP064894 | DPP4 | 1803 | RNAseq | 1.1556 | 0.0033 | |
| SRP133303 | DPP4 | 1803 | RNAseq | 1.3027 | 0.0064 | |
| SRP159526 | DPP4 | 1803 | RNAseq | 0.8700 | 0.1197 | |
| SRP193095 | DPP4 | 1803 | RNAseq | 1.5381 | 0.0004 | |
| SRP219564 | DPP4 | 1803 | RNAseq | 0.5522 | 0.2989 | |
| TCGA | DPP4 | 1803 | RNAseq | 0.0192 | 0.9392 |
Upregulated datasets: 7; Downregulated datasets: 1.
Survival by DPP4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DPP4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DPP4 | 1803 | 4 | 1 | 25 | |
| GSE20123 | DPP4 | 1803 | 4 | 1 | 25 | |
| GSE43470 | DPP4 | 1803 | 4 | 1 | 38 | |
| GSE46452 | DPP4 | 1803 | 1 | 4 | 54 | |
| GSE47630 | DPP4 | 1803 | 5 | 3 | 32 | |
| GSE54993 | DPP4 | 1803 | 0 | 5 | 65 | |
| GSE54994 | DPP4 | 1803 | 11 | 2 | 40 | |
| GSE60625 | DPP4 | 1803 | 0 | 3 | 8 | |
| GSE74703 | DPP4 | 1803 | 3 | 1 | 32 | |
| GSE74704 | DPP4 | 1803 | 3 | 0 | 17 | |
| TCGA | DPP4 | 1803 | 23 | 10 | 63 |
Total number of gains: 58; Total number of losses: 31; Total Number of normals: 399.
Somatic mutations of DPP4:
Generating mutation plots.
Highly correlated genes for DPP4:
Showing top 20/660 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DPP4 | TMX3 | 0.794237 | 3 | 0 | 3 |
| DPP4 | RGL1 | 0.788794 | 3 | 0 | 3 |
| DPP4 | C11orf96 | 0.785717 | 3 | 0 | 3 |
| DPP4 | DEGS1 | 0.780986 | 3 | 0 | 3 |
| DPP4 | CLIP3 | 0.775784 | 3 | 0 | 3 |
| DPP4 | MGAT5 | 0.770881 | 3 | 0 | 3 |
| DPP4 | MRVI1 | 0.769213 | 3 | 0 | 3 |
| DPP4 | MRC2 | 0.765097 | 3 | 0 | 3 |
| DPP4 | FBLN5 | 0.751008 | 4 | 0 | 4 |
| DPP4 | GLT8D2 | 0.744802 | 5 | 0 | 5 |
| DPP4 | SHANK3 | 0.732616 | 3 | 0 | 3 |
| DPP4 | FCGR3A | 0.731373 | 3 | 0 | 3 |
| DPP4 | LRRC8C | 0.731229 | 3 | 0 | 3 |
| DPP4 | ACSS3 | 0.728552 | 3 | 0 | 3 |
| DPP4 | RWDD2A | 0.723887 | 3 | 0 | 3 |
| DPP4 | KLF2 | 0.723862 | 3 | 0 | 3 |
| DPP4 | SSC5D | 0.722231 | 3 | 0 | 3 |
| DPP4 | TMEM158 | 0.719785 | 4 | 0 | 4 |
| DPP4 | CDIPT | 0.719275 | 3 | 0 | 3 |
| DPP4 | CTSO | 0.718627 | 4 | 0 | 4 |
For details and further investigation, click here
