GNA13

 

Full name: G protein subunit alpha 13 Alias Symbol: G13|MGC46138
Type: protein-coding gene Cytoband: 17q24.1
Entrez ID: 10672 HGNC ID: HGNC:4381 Ensembl Gene: ENSG00000120063 OMIM ID: 604406
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found 13/325 cell lines had fitness change in Project Score.
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

GNA13 involved pathways:

KEGG pathway Description View
hsa04022cGMP-PKG signaling pathway
hsa04071Sphingolipid signaling pathway
hsa04072Phospholipase D signaling pathway
hsa04270Vascular smooth muscle contraction
hsa04611Platelet activation
hsa04730Long-term depression
hsa04810Regulation of actin cytoskeleton

 

Expression of GNA13:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 GNA13 10672 224761_at 0.2385 0.5408
GSE20347 GNA13 10672 206917_at 0.1818 0.0346
GSE23400 GNA13 10672 206917_at 0.2202 0.0000
GSE26886 GNA13 10672 224761_at 0.9018 0.0001
GSE29001 GNA13 10672 206917_at 0.0674 0.5884
GSE38129 GNA13 10672 206917_at 0.1750 0.0487
GSE45670 GNA13 10672 224761_at 0.1405 0.4237
GSE53622 GNA13 10672 113808 0.5786 0.0000
GSE53624 GNA13 10672 113808 0.6222 0.0000
GSE63941 GNA13 10672 224761_at -0.3121 0.4962
GSE77861 GNA13 10672 224761_at 0.9305 0.0056
GSE97050 GNA13 10672 A_24_P941441 0.1691 0.3820
SRP007169 GNA13 10672 RNAseq 1.2884 0.0001
SRP008496 GNA13 10672 RNAseq 1.4266 0.0000
SRP064894 GNA13 10672 RNAseq 0.4526 0.0248
SRP133303 GNA13 10672 RNAseq 0.8101 0.0000
SRP159526 GNA13 10672 RNAseq 0.6296 0.0520
SRP193095 GNA13 10672 RNAseq 0.2916 0.0340
SRP219564 GNA13 10672 RNAseq 0.6523 0.0220
TCGA GNA13 10672 RNAseq 0.0879 0.0505

Upregulated datasets: 2; Downregulated datasets: 0.  

 

Survival by GNA13 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of GNA13:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 GNA13 10672 3 1 26
GSE20123 GNA13 10672 3 1 26
GSE43470 GNA13 10672 5 0 38
GSE46452 GNA13 10672 32 0 27
GSE47630 GNA13 10672 7 1 32
GSE54993 GNA13 10672 2 5 63
GSE54994 GNA13 10672 9 4 40
GSE60625 GNA13 10672 4 0 7
GSE74703 GNA13 10672 5 0 31
GSE74704 GNA13 10672 3 1 16
TCGA GNA13 10672 30 8 58

Total number of gains: 103; Total number of losses: 21; Total Number of normals: 364.  

 

Somatic mutations of GNA13:

 

Generating mutation plots.

 

Highly correlated genes for GNA13:

 

Showing top 20/1382 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
GNA13MAPRE20.876327303
GNA13RBM220.854702303
GNA13SEC16A0.826082303
GNA13NFATC10.807808303
GNA13TTF10.794058303
GNA13SLC29A10.785719303
GNA13PLEKHO20.782454303
GNA13GNG100.781951303
GNA13CIAO10.77113303
GNA13NOL90.768699404
GNA13MAML10.759836303
GNA13CEP3500.75944303
GNA13TBP0.744377303
GNA13EEFSEC0.743811303
GNA13PKIG0.740938404
GNA13PSMG30.740564303
GNA13UCP20.739549303
GNA13STRADA0.737511505
GNA13NACC10.734779303
GNA13DERL20.731659303

For details and further investigation, click here