| Full name: 1,4-alpha-glucan branching enzyme 1 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 3p12.2 | ||
| Entrez ID: 2632 | HGNC ID: HGNC:4180 | Ensembl Gene: ENSG00000114480 | OMIM ID: 607839 |
| Drug and gene relationship at DGIdb | |||
Expression of GBE1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GBE1 | 2632 | 203282_at | -0.2495 | 0.6817 | |
| GSE20347 | GBE1 | 2632 | 203282_at | -0.6758 | 0.0037 | |
| GSE23400 | GBE1 | 2632 | 203282_at | -0.0183 | 0.8455 | |
| GSE26886 | GBE1 | 2632 | 203282_at | -0.8261 | 0.0004 | |
| GSE29001 | GBE1 | 2632 | 203282_at | -0.5110 | 0.0472 | |
| GSE38129 | GBE1 | 2632 | 203282_at | -0.4129 | 0.0177 | |
| GSE45670 | GBE1 | 2632 | 203282_at | -0.1783 | 0.3659 | |
| GSE53622 | GBE1 | 2632 | 6927 | -0.5943 | 0.0000 | |
| GSE53624 | GBE1 | 2632 | 6927 | -0.4999 | 0.0000 | |
| GSE63941 | GBE1 | 2632 | 203282_at | -2.6418 | 0.0091 | |
| GSE77861 | GBE1 | 2632 | 203282_at | -0.7593 | 0.0037 | |
| GSE97050 | GBE1 | 2632 | A_23_P121082 | -0.1887 | 0.4609 | |
| SRP007169 | GBE1 | 2632 | RNAseq | -0.9287 | 0.0033 | |
| SRP008496 | GBE1 | 2632 | RNAseq | -0.3781 | 0.0933 | |
| SRP064894 | GBE1 | 2632 | RNAseq | -0.3686 | 0.0976 | |
| SRP133303 | GBE1 | 2632 | RNAseq | -0.1290 | 0.3344 | |
| SRP159526 | GBE1 | 2632 | RNAseq | -0.9035 | 0.0443 | |
| SRP193095 | GBE1 | 2632 | RNAseq | -0.8020 | 0.0000 | |
| SRP219564 | GBE1 | 2632 | RNAseq | -0.7518 | 0.0528 | |
| TCGA | GBE1 | 2632 | RNAseq | -0.0747 | 0.2149 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by GBE1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GBE1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GBE1 | 2632 | 2 | 17 | 11 | |
| GSE20123 | GBE1 | 2632 | 2 | 17 | 11 | |
| GSE43470 | GBE1 | 2632 | 1 | 22 | 20 | |
| GSE46452 | GBE1 | 2632 | 2 | 17 | 40 | |
| GSE47630 | GBE1 | 2632 | 4 | 19 | 17 | |
| GSE54993 | GBE1 | 2632 | 4 | 3 | 63 | |
| GSE54994 | GBE1 | 2632 | 1 | 29 | 23 | |
| GSE60625 | GBE1 | 2632 | 0 | 4 | 7 | |
| GSE74703 | GBE1 | 2632 | 1 | 20 | 15 | |
| GSE74704 | GBE1 | 2632 | 1 | 12 | 7 | |
| TCGA | GBE1 | 2632 | 1 | 77 | 18 |
Total number of gains: 19; Total number of losses: 237; Total Number of normals: 232.
Somatic mutations of GBE1:
Generating mutation plots.
Highly correlated genes for GBE1:
Showing top 20/884 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GBE1 | GPBP1 | 0.801866 | 3 | 0 | 3 |
| GBE1 | PDZD11 | 0.800669 | 3 | 0 | 3 |
| GBE1 | ZNF441 | 0.786694 | 3 | 0 | 3 |
| GBE1 | TMEM161B | 0.755952 | 4 | 0 | 4 |
| GBE1 | NKAPL | 0.75221 | 3 | 0 | 3 |
| GBE1 | CCDC25 | 0.743725 | 3 | 0 | 3 |
| GBE1 | ZNF407 | 0.739956 | 3 | 0 | 3 |
| GBE1 | NDUFAF2 | 0.736214 | 3 | 0 | 3 |
| GBE1 | EXOC6B | 0.728597 | 3 | 0 | 3 |
| GBE1 | LMAN1 | 0.723724 | 3 | 0 | 3 |
| GBE1 | PRKAR2A | 0.712131 | 5 | 0 | 5 |
| GBE1 | EIF4G3 | 0.71105 | 3 | 0 | 3 |
| GBE1 | DIMT1 | 0.710862 | 5 | 0 | 4 |
| GBE1 | FIBIN | 0.708259 | 3 | 0 | 3 |
| GBE1 | ABHD16A | 0.706553 | 3 | 0 | 3 |
| GBE1 | ETS1 | 0.702808 | 3 | 0 | 3 |
| GBE1 | BBIP1 | 0.696348 | 5 | 0 | 5 |
| GBE1 | GSDMC | 0.69401 | 5 | 0 | 4 |
| GBE1 | PGK1 | 0.693617 | 4 | 0 | 3 |
| GBE1 | ACTR3C | 0.693599 | 3 | 0 | 3 |
For details and further investigation, click here
